长期1.8 GHz电磁辐射对大鼠学习认知能力的影响
Q64%TL71; 研究低剂量下长期不间断电磁辐射暴露对发育期Sprague Dawley(SD)大鼠学习认知能力的影响,为电磁暴露安全限值标准的确定提供实验依据.利用1.8 GHz电磁波对大鼠进行全天不间断辐照,白天8 h工作时间的剂量为0.40 W/kg,其余时间为0.08 W/kg,持续4周.通过水迷宫实验检测大鼠学习记忆能力,采用化学比色法检测大鼠海马组织中胆碱能标志物水平、单胺类神经递质水平、抗氧化物酶活性和氧化应激产物含量,并对海马组织进行切片、染色和观察.结果表明,实验组大鼠大脑内海马组织较假辐照组无显著性差异,但实验组大鼠胆碱酯酶含量降低,乙酰胆碱含量和乙酰胆碱转移酶的活性上升...
Saved in:
Published in | 辐射研究与辐射工艺学报 Vol. 39; no. 4; pp. 17 - 23 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | Chinese |
Published |
华东师范大学物理与电子科学学院生物物理实验室 上海 200241
01.08.2021
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Q64%TL71; 研究低剂量下长期不间断电磁辐射暴露对发育期Sprague Dawley(SD)大鼠学习认知能力的影响,为电磁暴露安全限值标准的确定提供实验依据.利用1.8 GHz电磁波对大鼠进行全天不间断辐照,白天8 h工作时间的剂量为0.40 W/kg,其余时间为0.08 W/kg,持续4周.通过水迷宫实验检测大鼠学习记忆能力,采用化学比色法检测大鼠海马组织中胆碱能标志物水平、单胺类神经递质水平、抗氧化物酶活性和氧化应激产物含量,并对海马组织进行切片、染色和观察.结果表明,实验组大鼠大脑内海马组织较假辐照组无显著性差异,但实验组大鼠胆碱酯酶含量降低,乙酰胆碱含量和乙酰胆碱转移酶的活性上升,神经递质多巴胺、5-羟色胺含量较假辐照组也显著增加.水迷宫结果显示,实验组大鼠行为上无显著性变化.长期低剂量电磁辐射会导致SD大鼠胆碱能系统与神经递质水平紊乱,但这些指标的变化没有引起大鼠学习记忆能力的下降,而且胆碱能系统标志物与神经递质水平在14 d后基本恢复正常. |
---|---|
AbstractList | Q64%TL71; 研究低剂量下长期不间断电磁辐射暴露对发育期Sprague Dawley(SD)大鼠学习认知能力的影响,为电磁暴露安全限值标准的确定提供实验依据.利用1.8 GHz电磁波对大鼠进行全天不间断辐照,白天8 h工作时间的剂量为0.40 W/kg,其余时间为0.08 W/kg,持续4周.通过水迷宫实验检测大鼠学习记忆能力,采用化学比色法检测大鼠海马组织中胆碱能标志物水平、单胺类神经递质水平、抗氧化物酶活性和氧化应激产物含量,并对海马组织进行切片、染色和观察.结果表明,实验组大鼠大脑内海马组织较假辐照组无显著性差异,但实验组大鼠胆碱酯酶含量降低,乙酰胆碱含量和乙酰胆碱转移酶的活性上升,神经递质多巴胺、5-羟色胺含量较假辐照组也显著增加.水迷宫结果显示,实验组大鼠行为上无显著性变化.长期低剂量电磁辐射会导致SD大鼠胆碱能系统与神经递质水平紊乱,但这些指标的变化没有引起大鼠学习记忆能力的下降,而且胆碱能系统标志物与神经递质水平在14 d后基本恢复正常. |
Author | 高蒙 彭怀禹 侯毅然 童嘉锴 齐红新 张杰 王向晖 |
AuthorAffiliation | 华东师范大学物理与电子科学学院生物物理实验室 上海 200241 |
AuthorAffiliation_xml | – name: 华东师范大学物理与电子科学学院生物物理实验室 上海 200241 |
Author_FL | PENG Huaiyu GAO Meng WANG Xianghui TONG Jiakai ZHANG Jie QI Hongxin HOU Yiran |
Author_FL_xml | – sequence: 1 fullname: GAO Meng – sequence: 2 fullname: PENG Huaiyu – sequence: 3 fullname: WANG Xianghui – sequence: 4 fullname: QI Hongxin – sequence: 5 fullname: HOU Yiran – sequence: 6 fullname: TONG Jiakai – sequence: 7 fullname: ZHANG Jie |
Author_xml | – sequence: 1 fullname: 高蒙 – sequence: 2 fullname: 彭怀禹 – sequence: 3 fullname: 王向晖 – sequence: 4 fullname: 齐红新 – sequence: 5 fullname: 侯毅然 – sequence: 6 fullname: 童嘉锴 – sequence: 7 fullname: 张杰 |
BookMark | eNo9j71KA0EURqeIYIx5Bzsbd5w7NzuZKSwkaCIEbLQOM9md4CIbyCIaOzGVIAjRRoUEjFr5V1gEjL6M4yZvYUSxOsUH5-PMkUzcjENCFoFRACnVckSBMeZhAQXljANttSKKirICQwYZkv2fZ0k-SXYM8wGLvhI8S1YmFx9f1z2gcqFcOUzPX9Obo_H7mXvuuKehG9xP3vru4e5z2B8_DtLe7fh45E6u0suOG7247uk8mbF6Nwnzf8yR7fW1rVLFq26WN0qrVS8BVkRPMivCus-FtSGEShkpjCogR60CEFpJEwohfaPBRy4FB2HqRgdQL6LAwASYI0u_3n0dWx03alFzrxVPH2s2aUdtmzTaB-YnfZrMEL8Bw3NkLw |
ClassificationCodes | Q64%TL71 |
ContentType | Journal Article |
Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
DBID | 2B. 4A8 92I 93N PSX TCJ |
DOI | 10.11889/j.1000-3436.2021.rrj.39.040301 |
DatabaseName | Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
DatabaseTitleList | |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
DocumentTitle_FL | Effect of long-term 1.8 GHz combined electromagnetic radiation on the learning and cognitive ability of rats |
EndPage | 23 |
ExternalDocumentID | fsyjyfsgyxb202104003 |
GrantInformation_xml | – fundername: 国家自然科学基金项目 funderid: (31600675) |
GroupedDBID | -03 2B. 2C0 4A8 5XA 5XD 92H 92I 93N ACGFS ALMA_UNASSIGNED_HOLDINGS CCEZO CEKLB CW9 GROUPED_DOAJ PSX TCJ TGT U1G U5M |
ID | FETCH-LOGICAL-s1073-80f6ec526ffe1e99b86b94323a9d16a98be6685ba153286216bcbad1c7363dbd3 |
ISSN | 1000-3436 |
IngestDate | Wed Nov 06 04:32:56 EST 2024 |
IsPeerReviewed | false |
IsScholarly | true |
Issue | 4 |
Keywords | 胆碱能系统 低剂量辐射 Morris水迷宫 氧化应激 神经递质 |
Language | Chinese |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-s1073-80f6ec526ffe1e99b86b94323a9d16a98be6685ba153286216bcbad1c7363dbd3 |
PageCount | 7 |
ParticipantIDs | wanfang_journals_fsyjyfsgyxb202104003 |
PublicationCentury | 2000 |
PublicationDate | 2021-08-01 |
PublicationDateYYYYMMDD | 2021-08-01 |
PublicationDate_xml | – month: 08 year: 2021 text: 2021-08-01 day: 01 |
PublicationDecade | 2020 |
PublicationTitle | 辐射研究与辐射工艺学报 |
PublicationTitle_FL | Journal of Radiation Research and Radiation Processing |
PublicationYear | 2021 |
Publisher | 华东师范大学物理与电子科学学院生物物理实验室 上海 200241 |
Publisher_xml | – name: 华东师范大学物理与电子科学学院生物物理实验室 上海 200241 |
SSID | ssib051375962 ssib001129923 ssj0040334 |
Score | 2.2880952 |
Snippet | Q64%TL71; 研究低剂量下长期不间断电磁辐射暴露对发育期Sprague Dawley(SD)大鼠学习认知能力的影响,为电磁暴露安全限值标准的确定提供实验依据.利用1.8 GHz电磁波对大鼠进行全天不间断辐照,白天8 h工作时间的剂量为0.40 W/kg,其余时间为0.08... |
SourceID | wanfang |
SourceType | Aggregation Database |
StartPage | 17 |
Title | 长期1.8 GHz电磁辐射对大鼠学习认知能力的影响 |
URI | https://d.wanfangdata.com.cn/periodical/fsyjyfsgyxb202104003 |
Volume | 39 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Na9RAFB9qheKl-Inf9ODgoeyaZJLJzMHDZDdrEeqphd5KPis9bKHbgu1N7EkQBPWiQgtWPfl18FCw-s8Yt_0vfG8m2Y26SBWWMEzevPd772XyXrIzL4RcyyweRSLNGjLL84bLM9aImc0bvuWkWeJhQV_8R3f2Dp-Zd28veAtj45O1VUvra3Ez2Ry5r-R_vAp94FfcJfsPnh0whQ5og3_hCB6G45F8TENJpUeDDg05lS0qO3ZTTN-a2aShT6VLAw8bikG6SENBg5BKi4YwwKLCxYbq0EDqhkuVj-yCFlWaRrWp4jR0kQB7BFUhkiHnDlUe9ghGgzYSC0VloE-pkjP0BzY2JEhv11PgUUh8FCFNAzAYucA_HA078CsAQKxqaDkiUV51FaFCKqBSIK10qJTDMxoiDMMxFv5QNgdthyQ-AhCB1gLg2drKYHFe5w9cpB4MQJSjSYCLVX-b4tiDtXzm-tcma2v1tJ7gOsQD-mikooWWHXploJ6PCoOB0NCAuW6mgb81sUEEY6VdGz5oSFQDwepR4M46599FeOh4GWpbKsRmepQ7XYlXqHWAbsEClY4pMVZGOiwpwFxTfaYKhaauVDnl3VpcM_trywzJbBD_M_YKIU3wrVg30cLN1dXlJsxdiBastPSvBc7z3sbyRt5b2rgXIz1GFXaMHHcgcvDaOxKd30N2Wnve92zm49ejqtQLJJhlJBWACXK9Qnbj77j0nr1uHnWXaunl3EkyWT4XTikzyU-Rsc27p8nEbLny5Qy5efjs24-X2zC_p2B-959-7r-6f_D1cfFxq_iwV-y-PfyyU7x7831v5-D9bn_79cGD_eLhi_7zrWL_U_Hk0Vky3wnnWjON8tMnjZ4NQRfyxpzDrdLheZ7ZmZSx4LF0mcMimdo8kiLOOBdeHEHC4gju2DxO4ii1E59xlsYpO0fGuyvd7DyZYjJPU5FDooqVoFwROyJKXJnzNElSnlgXCC01Xyxvbb3FUS65eES6S-TEcGJdJuNrq-vZFUjc1-Kr2pk_Ab6OrG4 |
link.rule.ids | 315,783,787,867,27936,27937 |
linkProvider | Directory of Open Access Journals |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E9%95%BF%E6%9C%9F1.8+GHz%E7%94%B5%E7%A3%81%E8%BE%90%E5%B0%84%E5%AF%B9%E5%A4%A7%E9%BC%A0%E5%AD%A6%E4%B9%A0%E8%AE%A4%E7%9F%A5%E8%83%BD%E5%8A%9B%E7%9A%84%E5%BD%B1%E5%93%8D&rft.jtitle=%E8%BE%90%E5%B0%84%E7%A0%94%E7%A9%B6%E4%B8%8E%E8%BE%90%E5%B0%84%E5%B7%A5%E8%89%BA%E5%AD%A6%E6%8A%A5&rft.au=%E9%AB%98%E8%92%99&rft.au=%E5%BD%AD%E6%80%80%E7%A6%B9&rft.au=%E7%8E%8B%E5%90%91%E6%99%96&rft.au=%E9%BD%90%E7%BA%A2%E6%96%B0&rft.date=2021-08-01&rft.pub=%E5%8D%8E%E4%B8%9C%E5%B8%88%E8%8C%83%E5%A4%A7%E5%AD%A6%E7%89%A9%E7%90%86%E4%B8%8E%E7%94%B5%E5%AD%90%E7%A7%91%E5%AD%A6%E5%AD%A6%E9%99%A2%E7%94%9F%E7%89%A9%E7%89%A9%E7%90%86%E5%AE%9E%E9%AA%8C%E5%AE%A4+%E4%B8%8A%E6%B5%B7+200241&rft.issn=1000-3436&rft.volume=39&rft.issue=4&rft.spage=17&rft.epage=23&rft_id=info:doi/10.11889%2Fj.1000-3436.2021.rrj.39.040301&rft.externalDocID=fsyjyfsgyxb202104003 |
thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Ffsyjyfsgyxb%2Ffsyjyfsgyxb.jpg |