妊娠期糖尿病母亲所产新生儿脐带血皮质醇水平变化及其对子代健康的影响
R714.256; 目的·探讨妊娠期糖尿病(gestational diabetes mellitus,GDM)对新生儿脐带血皮质醇水平的影响,并探索围产期高皮质醇暴露对子代学龄前期健康状况的影响.方法·纳入170例产妇及其足月、单胎分娩新生儿,其中GDM组产妇66例、孕期正常糖耐量(normal glucose tolerance,NGT)组产妇104例.采集新生儿的脐带血,测量其皮质醇及促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)浓度.利用SPSS软件分析GDM对新生儿脐带血皮质醇及ACTH水平的影响.采用多元线性回归模型分析新生儿脐带血皮质醇水平的...
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| Published in | 上海交通大学学报（医学版） Vol. 41; no. 1; pp. 49 - 54 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
上海交通大学医学院附属国际和平妇幼保健院妇产科,上海胚胎源性疾病重点实验室,上海 200030
28.01.2021
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1674-8115 |
| DOI | 10.3969/j.issn.1674-8115.2021.01.008 |
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| Abstract | R714.256; 目的·探讨妊娠期糖尿病(gestational diabetes mellitus,GDM)对新生儿脐带血皮质醇水平的影响,并探索围产期高皮质醇暴露对子代学龄前期健康状况的影响.方法·纳入170例产妇及其足月、单胎分娩新生儿,其中GDM组产妇66例、孕期正常糖耐量(normal glucose tolerance,NGT)组产妇104例.采集新生儿的脐带血,测量其皮质醇及促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)浓度.利用SPSS软件分析GDM对新生儿脐带血皮质醇及ACTH水平的影响.采用多元线性回归模型分析新生儿脐带血皮质醇水平的影响因素.采用Pearsonχ2检验分析围产期高皮质醇对子代学龄前期健康状况的影响,并采用二元Logistic回归模型分析子代学龄前期肥胖的影响因素.结果·与NGT组相比,GDM组新生儿的脐带血皮质醇水平较高,ACTH水平较低(均P<0.05).多元线性回归分析显示,母亲孕次、75 g葡萄糖耐量试验(oral glucose tolerance test,OGTT)服糖后1 h及2 h血糖水平是新生儿脐带血皮质醇水平的独立影响因素(均P<0.05).随访结果显示,围产期较高水平皮质醇的子代学龄前期肥胖率较高(P=0.009).二元Logistic回归分析证实新生儿脐带血皮质醇水平≥192.00 ng/mL是学龄前期肥胖的独立危险因素(OR=4.714,P=0.016).结论·GDM引起新生儿脐带血皮质醇升高,围产期高皮质醇暴露导致子代学龄前期肥胖风险增加,GDM可能通过围产期高皮质醇暴露引起子代远期疾病. |
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| AbstractList | R714.256; 目的·探讨妊娠期糖尿病(gestational diabetes mellitus,GDM)对新生儿脐带血皮质醇水平的影响,并探索围产期高皮质醇暴露对子代学龄前期健康状况的影响.方法·纳入170例产妇及其足月、单胎分娩新生儿,其中GDM组产妇66例、孕期正常糖耐量(normal glucose tolerance,NGT)组产妇104例.采集新生儿的脐带血,测量其皮质醇及促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)浓度.利用SPSS软件分析GDM对新生儿脐带血皮质醇及ACTH水平的影响.采用多元线性回归模型分析新生儿脐带血皮质醇水平的影响因素.采用Pearsonχ2检验分析围产期高皮质醇对子代学龄前期健康状况的影响,并采用二元Logistic回归模型分析子代学龄前期肥胖的影响因素.结果·与NGT组相比,GDM组新生儿的脐带血皮质醇水平较高,ACTH水平较低(均P<0.05).多元线性回归分析显示,母亲孕次、75 g葡萄糖耐量试验(oral glucose tolerance test,OGTT)服糖后1 h及2 h血糖水平是新生儿脐带血皮质醇水平的独立影响因素(均P<0.05).随访结果显示,围产期较高水平皮质醇的子代学龄前期肥胖率较高(P=0.009).二元Logistic回归分析证实新生儿脐带血皮质醇水平≥192.00 ng/mL是学龄前期肥胖的独立危险因素(OR=4.714,P=0.016).结论·GDM引起新生儿脐带血皮质醇升高,围产期高皮质醇暴露导致子代学龄前期肥胖风险增加,GDM可能通过围产期高皮质醇暴露引起子代远期疾病. |
| Author | 赵奕然 朱雅洁 刘欣梅 林慧 黄荷凤 陈茜 |
| AuthorAffiliation | 上海交通大学医学院附属国际和平妇幼保健院妇产科,上海胚胎源性疾病重点实验室,上海 200030 |
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| Author_FL | HUANG He-feng ZHU Ya-jie LIU Xin-mei LIN Hui CHEN Xi ZHAO Yi-ran |
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| Keywords | 妊娠期糖尿病 肥胖 脐带血 糖皮质激素 产前暴露迟发效应 |
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| Publisher | 上海交通大学医学院附属国际和平妇幼保健院妇产科,上海胚胎源性疾病重点实验室,上海 200030 |
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| Snippet | R714.256; 目的·探讨妊娠期糖尿病(gestational diabetes mellitus,GDM)对新生儿脐带血皮质醇水平的影响,并探索围产期高皮质醇暴露对子代学龄前期健康状况的影响.方法·纳入170例产妇及其足月、单胎分娩新生儿,其中GDM组产妇66例、孕期正常糖耐量(normal glucose... |
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| Title | 妊娠期糖尿病母亲所产新生儿脐带血皮质醇水平变化及其对子代健康的影响 |
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