银胶菊中木脂素类成分的研究
R284.2; 研究银胶菊Parthieniumhysterophorus Linn.中木脂素类化学成分.采用硅胶、Sephadex LH-20、MCI、ODS和半制备型HPLC等色谱技术,从银胶菊地上部分的95％乙醇提取物中分离得到5个木脂素类化合物(1～5),通过波谱学数据分析,将它们的结构分别鉴定为(7S,8S,7'E)-4,9,9'-三羟基-3,5,7,3',5'-五甲氧基-8,4'-氧新木脂素-7'-烯(1)、丁香脂素(2)、杜仲树脂酚(3)、松脂素(4)、五味子醇甲(5).其中,化合物1为新化合物,化合物3～5为首次从银胶...
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| Published in | 天然产物研究与开发 Vol. 35; no. 5; pp. 761 - 780 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
桂林医学院药学院,桂林541199
26.05.2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-6880 |
| DOI | 10.16333/j.1001-6880.2023.5.004 |
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| Abstract | R284.2; 研究银胶菊Parthieniumhysterophorus Linn.中木脂素类化学成分.采用硅胶、Sephadex LH-20、MCI、ODS和半制备型HPLC等色谱技术,从银胶菊地上部分的95％乙醇提取物中分离得到5个木脂素类化合物(1～5),通过波谱学数据分析,将它们的结构分别鉴定为(7S,8S,7'E)-4,9,9'-三羟基-3,5,7,3',5'-五甲氧基-8,4'-氧新木脂素-7'-烯(1)、丁香脂素(2)、杜仲树脂酚(3)、松脂素(4)、五味子醇甲(5).其中,化合物1为新化合物,化合物3～5为首次从银胶菊中分离得到.对所有化合物进行了体外抗神经炎症活性筛选,结果显示,化合物1对LPS激活的BV-2小胶质细胞释放NO具有显著抑制作用,IC50为21.10±1.97 μmol/L,其余化合物均无活性,且所有化合物在测试浓度下均不影响细胞的存活率. |
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| AbstractList | R284.2; 研究银胶菊Parthieniumhysterophorus Linn.中木脂素类化学成分.采用硅胶、Sephadex LH-20、MCI、ODS和半制备型HPLC等色谱技术,从银胶菊地上部分的95％乙醇提取物中分离得到5个木脂素类化合物(1～5),通过波谱学数据分析,将它们的结构分别鉴定为(7S,8S,7'E)-4,9,9'-三羟基-3,5,7,3',5'-五甲氧基-8,4'-氧新木脂素-7'-烯(1)、丁香脂素(2)、杜仲树脂酚(3)、松脂素(4)、五味子醇甲(5).其中,化合物1为新化合物,化合物3～5为首次从银胶菊中分离得到.对所有化合物进行了体外抗神经炎症活性筛选,结果显示,化合物1对LPS激活的BV-2小胶质细胞释放NO具有显著抑制作用,IC50为21.10±1.97 μmol/L,其余化合物均无活性,且所有化合物在测试浓度下均不影响细胞的存活率. |
| Author | 李红霞 王素娟 李华 张贵杰 |
| AuthorAffiliation | 桂林医学院药学院,桂林541199 |
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| Author_FL | ZHANG Gui-jie LI Hua LI Hong-xia WANG Su-juan |
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| DocumentTitle_FL | Lignans from Parthenium hysterophorus Linn |
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| Keywords | lignan 抗神经炎症活性 Parthenium hysterophorus Linn 银胶菊 木脂素 microglia anti-neuroinflammatory 小胶质细胞 |
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| Title | 银胶菊中木脂素类成分的研究 |
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