基于"虚气流滞"病机探讨抑郁症"炎症-线粒体损伤"恶性循环假说

R259; 抑郁症是一种危害极大的心身疾病,其发病机制和病机演变过程十分复杂,本文在王永炎院士提出的"虚气流滞"病机理论的指导下,深入剖析了抑郁症"虚气流滞"的病机特点,详细阐述了抑郁症以虚气为本、流滞为标,虚气与流滞相互裹挟、恶性循环的病机特点和演变规律,同时基于诸多研究提出抑郁症"炎症-线粒体损伤"恶性循环假说,并指出线粒体是打破恶性循环的关键治疗靶点,保护线粒体是抑郁症"补虚培元"治则的潜在生物学实质,为研究抑郁症的发病机制和防治方法提供新的思路....

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Published in北京中医药大学学报 Vol. 45; no. 11; pp. 1175 - 1181
Main Authors 赵钟辉, 郭蓉娟, 高维, 李阳, 于姚, 李俊男, 杨丽旋, 段文喆
Format Journal Article
LanguageChinese
Published 北京中医药大学 北京 100029%北京中医药大学东方医院%清华大学玉泉医院%首都医科大学附属北京中医医院%北京市昌平区中西医结合医院 01.11.2022
Subjects
虚气流滞
病机
线粒体
抑郁症
炎症
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ISSN1006-2157
DOI10.3969/j.issn.1006-2157.2022.11.006

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Abstract R259; 抑郁症是一种危害极大的心身疾病,其发病机制和病机演变过程十分复杂,本文在王永炎院士提出的"虚气流滞"病机理论的指导下,深入剖析了抑郁症"虚气流滞"的病机特点,详细阐述了抑郁症以虚气为本、流滞为标,虚气与流滞相互裹挟、恶性循环的病机特点和演变规律,同时基于诸多研究提出抑郁症"炎症-线粒体损伤"恶性循环假说,并指出线粒体是打破恶性循环的关键治疗靶点,保护线粒体是抑郁症"补虚培元"治则的潜在生物学实质,为研究抑郁症的发病机制和防治方法提供新的思路.
AbstractList R259; 抑郁症是一种危害极大的心身疾病,其发病机制和病机演变过程十分复杂,本文在王永炎院士提出的"虚气流滞"病机理论的指导下,深入剖析了抑郁症"虚气流滞"的病机特点,详细阐述了抑郁症以虚气为本、流滞为标,虚气与流滞相互裹挟、恶性循环的病机特点和演变规律,同时基于诸多研究提出抑郁症"炎症-线粒体损伤"恶性循环假说,并指出线粒体是打破恶性循环的关键治疗靶点,保护线粒体是抑郁症"补虚培元"治则的潜在生物学实质,为研究抑郁症的发病机制和防治方法提供新的思路.
Author 郭蓉娟
段文喆
于姚
李俊男
李阳
杨丽旋
赵钟辉
高维
AuthorAffiliation 北京中医药大学 北京 100029%北京中医药大学东方医院%清华大学玉泉医院%首都医科大学附属北京中医医院%北京市昌平区中西医结合医院
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DUAN Wenzhe
YANG Lixuan
ZHAO Zhonghui
LI Yang
GAO Wei
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GUO Rongjuan
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Issue 11
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病机
线粒体
抑郁症
炎症
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Title 基于"虚气流滞"病机探讨抑郁症"炎症-线粒体损伤"恶性循环假说
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