脑组织净水摄取率在急性缺血性卒中诊断和治疗中应用的研究进展

R445.3%R743.3; 我国卒中发病呈现年轻化趋势,恶性脑水肿是大血管闭塞(LVO)性急性缺血性卒中(AIS)的严重并发症,与不良预后高度相关.现有的主观和定性的脑水肿预测指征包括大脑中动脉高密度征、基线梗死体积较大和治疗不及时等.近年来,脑组织净水摄取率(NWU)及其衍生的与时间呈(非)线性关系参数的提出为临床提供了缺血脑组织吸水量的定量信息,作为病理生理学和影像标志物可反映脑组织水肿程度并用于区分AIS发病时间窗,反映病变区侧支循环状态,并可进一步预测血管内治疗后水肿进展、恶性脑水肿(MCE)的发生、量化治疗效果和预后.目前,国内外学者对于NWU的研究相对较少,且多聚焦于NWU在MC...

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Published in吉林大学学报（医学版） Vol. 49; no. 1; pp. 237 - 243
Main Authors 宁聪, 陈忠萍, 石珍珍, 史晟先, 王猛, 佟丹
Format Journal Article
LanguageChinese
Published 吉林大学第一医院放射线科,吉林 长春 130021 2023
Subjects
大血管闭塞
净水摄取率
急性缺血性卒中
脑水肿
Online AccessGet full text
ISSN1671-587X
DOI10.13481/j.1671-587X.20230132

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Abstract R445.3%R743.3; 我国卒中发病呈现年轻化趋势,恶性脑水肿是大血管闭塞(LVO)性急性缺血性卒中(AIS)的严重并发症,与不良预后高度相关.现有的主观和定性的脑水肿预测指征包括大脑中动脉高密度征、基线梗死体积较大和治疗不及时等.近年来,脑组织净水摄取率(NWU)及其衍生的与时间呈(非)线性关系参数的提出为临床提供了缺血脑组织吸水量的定量信息,作为病理生理学和影像标志物可反映脑组织水肿程度并用于区分AIS发病时间窗,反映病变区侧支循环状态,并可进一步预测血管内治疗后水肿进展、恶性脑水肿(MCE)的发生、量化治疗效果和预后.目前,国内外学者对于NWU的研究相对较少,且多聚焦于NWU在MCE中的应用,现就脑水肿的形成机制、现有脑水肿的预测方法、NWU在AIS诊断及治疗中的优势和研究进展进行综述,旨在为NWU在AIS中的应用提供参考.
AbstractList R445.3%R743.3; 我国卒中发病呈现年轻化趋势,恶性脑水肿是大血管闭塞(LVO)性急性缺血性卒中(AIS)的严重并发症,与不良预后高度相关.现有的主观和定性的脑水肿预测指征包括大脑中动脉高密度征、基线梗死体积较大和治疗不及时等.近年来,脑组织净水摄取率(NWU)及其衍生的与时间呈(非)线性关系参数的提出为临床提供了缺血脑组织吸水量的定量信息,作为病理生理学和影像标志物可反映脑组织水肿程度并用于区分AIS发病时间窗,反映病变区侧支循环状态,并可进一步预测血管内治疗后水肿进展、恶性脑水肿(MCE)的发生、量化治疗效果和预后.目前,国内外学者对于NWU的研究相对较少,且多聚焦于NWU在MCE中的应用,现就脑水肿的形成机制、现有脑水肿的预测方法、NWU在AIS诊断及治疗中的优势和研究进展进行综述,旨在为NWU在AIS中的应用提供参考.
Author 宁聪
石珍珍
佟丹
史晟先
陈忠萍
王猛
AuthorAffiliation 吉林大学第一医院放射线科,吉林 长春 130021
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Keywords 大血管闭塞
净水摄取率
急性缺血性卒中
脑水肿
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Title 脑组织净水摄取率在急性缺血性卒中诊断和治疗中应用的研究进展
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