基于小肠胆固醇转运蛋白调控脂质吸收探讨"小肠泌别清浊"的生物学内涵及在痰湿体质调体干预中的临床应用
R259.892; 痰湿体质是肥胖、高脂血症等多种代谢性疾病的共同土壤.多数医家将机体的代谢功能归于脾脏,然而,其与小肠的关系也同样密切."小肠泌别清浊"是对小肠吸收、消化和排泄功能的总结.本团队提出小肠功能失调是痰湿体质者发生脂代谢紊乱的重要病理因素,但其微观机制尚不清楚."小肠泌别清浊"与胆固醇转运蛋白尼曼-匹克C1型类蛋白1(NPC1L1)调控脂质吸收、转运有相似的学术内涵,本文拟从NPC1L1的角度为"小肠泌别清浊"理论作出新的解读,也可证实"小肠泌别清浊"与代谢紊乱的关系.益气健运汤对于痰湿体质代谢紊乱疗...
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| Published in | 北京中医药大学学报 Vol. 46; no. 10; pp. 1411 - 1416 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
北京中医药大学 北京 100029
01.10.2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1006-2157 |
| DOI | 10.3969/j.issn.1006-2157.2023.10.012 |
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| Abstract | R259.892; 痰湿体质是肥胖、高脂血症等多种代谢性疾病的共同土壤.多数医家将机体的代谢功能归于脾脏,然而,其与小肠的关系也同样密切."小肠泌别清浊"是对小肠吸收、消化和排泄功能的总结.本团队提出小肠功能失调是痰湿体质者发生脂代谢紊乱的重要病理因素,但其微观机制尚不清楚."小肠泌别清浊"与胆固醇转运蛋白尼曼-匹克C1型类蛋白1(NPC1L1)调控脂质吸收、转运有相似的学术内涵,本文拟从NPC1L1的角度为"小肠泌别清浊"理论作出新的解读,也可证实"小肠泌别清浊"与代谢紊乱的关系.益气健运汤对于痰湿体质代谢紊乱疗效确切,方中药物均具有调节NPC1L1表达的生物学效应.从NPC1L1调控脂质吸收的角度为基于"小肠泌别清浊"的中医治法提供了新的作用靶点,丰富了益气健运汤药效机制的现代科学内涵,也为痰湿体质的调体和代谢性疾病的诊疗提供新的理论依据和临床思路. |
|---|---|
| AbstractList | R259.892; 痰湿体质是肥胖、高脂血症等多种代谢性疾病的共同土壤.多数医家将机体的代谢功能归于脾脏,然而,其与小肠的关系也同样密切."小肠泌别清浊"是对小肠吸收、消化和排泄功能的总结.本团队提出小肠功能失调是痰湿体质者发生脂代谢紊乱的重要病理因素,但其微观机制尚不清楚."小肠泌别清浊"与胆固醇转运蛋白尼曼-匹克C1型类蛋白1(NPC1L1)调控脂质吸收、转运有相似的学术内涵,本文拟从NPC1L1的角度为"小肠泌别清浊"理论作出新的解读,也可证实"小肠泌别清浊"与代谢紊乱的关系.益气健运汤对于痰湿体质代谢紊乱疗效确切,方中药物均具有调节NPC1L1表达的生物学效应.从NPC1L1调控脂质吸收的角度为基于"小肠泌别清浊"的中医治法提供了新的作用靶点,丰富了益气健运汤药效机制的现代科学内涵,也为痰湿体质的调体和代谢性疾病的诊疗提供新的理论依据和临床思路. |
| Author | 张安琪 姚海强 王琦 万瑾毅 |
| AuthorAffiliation | 北京中医药大学 北京 100029 |
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| Author_FL | WANG Qi WAN Jinyi YAO Haiqiang ZHANG Anqi |
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| Author_xml | – sequence: 1 fullname: 张安琪 – sequence: 2 fullname: 王琦 – sequence: 3 fullname: 万瑾毅 – sequence: 4 fullname: 姚海强 |
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| DocumentTitle_FL | Discussion on the biological connotation of "small intestine separating purity from turbidity" theory and its clinical application in the intervention of the phlegm-dampness constitution from the perspective of intestinal cholesterol transporter protein regulating lipid absorption |
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| Keywords | Yiqi Jianyun Decoction 痰湿体质 metabolic disorder phlegm-dampness constitution small intestine separating purity from turbidity 尼曼-匹克C1型类蛋白1 益气健运汤 小肠泌别清浊 代谢紊乱 Niemann-Pick C1-like 1 |
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| Title | 基于小肠胆固醇转运蛋白调控脂质吸收探讨"小肠泌别清浊"的生物学内涵及在痰湿体质调体干预中的临床应用 |
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