不同治疗量血小板的输注疗效以及影响因素分析

R457.1; 目的 对比分析患者输注不同治疗量血小板的输注疗效,并分析血小板输注无效的危险因素.方法 选择2023年5月至2024年5月在本院输注血小板患者5827例作为研究对象.输注1治疗量血小板4780例,输注0.5治疗量血小板1047例,比较2组血小板输注疗效.采用单因素分析的方法,分析患者性别、疾病种类、输注前白细胞计数、发热、血小板输注次数、血小板抗体对血小板输注无效的影响.再进一步使用多因素Logistic回归分析影响患者输注无效的独立危险因素.结果 4780例患者输注1治疗量血小板有效3553例(74.3％),无效1227例(25.7％).1047例患者输注0.5治疗量血小板有...

Full description

Saved in:
Bibliographic Details
Published in中国输血杂志 Vol. 37; no. 12; pp. 1383 - 1387
Main Authors 朱建玲, 程婷婷, 马春娅, 付丽辉, 师红梅, 于洋
Format Journal Article
LanguageChinese
Published 中国人民解放军总医院第一医学中心输血医学科,北京1000853 01.12.2024
Subjects
0.5治疗量
platelet transfusion efficacy
0.5 therapeutic dose
多因素分析
1 therapeutic dose
multivariate analysis
1治疗量
血小板输注疗效
Online AccessGet full text

Cover

Abstract R457.1; 目的 对比分析患者输注不同治疗量血小板的输注疗效,并分析血小板输注无效的危险因素.方法 选择2023年5月至2024年5月在本院输注血小板患者5827例作为研究对象.输注1治疗量血小板4780例,输注0.5治疗量血小板1047例,比较2组血小板输注疗效.采用单因素分析的方法,分析患者性别、疾病种类、输注前白细胞计数、发热、血小板输注次数、血小板抗体对血小板输注无效的影响.再进一步使用多因素Logistic回归分析影响患者输注无效的独立危险因素.结果 4780例患者输注1治疗量血小板有效3553例(74.3％),无效1227例(25.7％).1047例患者输注0.5治疗量血小板有效755例(72.1％),无效292例(27.9％).2组患者输注血小板有效率无明显差异(P>0.05).单因素分析均发现2组血小板输注疗效与年龄、血小板输注次数、疾病种类、血小板抗体、输注前白细胞计数有关(P<0.05),而性别、发热、血型与血小板输注疗效无关(P>0.05).多因素分析结果均显示年龄、白细胞计数>50×109/L、血小板输注次数、疾病种类以及血小板抗体是输注无效的独立危险因素(P<0.05).结论 患者输注0.5治疗量或者1治疗量血小板的输注疗效无明显差异.此外,年龄、白细胞计数>50×109/L、血小板输注次数、疾病种类以及血小板抗体是2组患者血小板输注无效的影响因素.
AbstractList R457.1; 目的 对比分析患者输注不同治疗量血小板的输注疗效,并分析血小板输注无效的危险因素.方法 选择2023年5月至2024年5月在本院输注血小板患者5827例作为研究对象.输注1治疗量血小板4780例,输注0.5治疗量血小板1047例,比较2组血小板输注疗效.采用单因素分析的方法,分析患者性别、疾病种类、输注前白细胞计数、发热、血小板输注次数、血小板抗体对血小板输注无效的影响.再进一步使用多因素Logistic回归分析影响患者输注无效的独立危险因素.结果 4780例患者输注1治疗量血小板有效3553例(74.3％),无效1227例(25.7％).1047例患者输注0.5治疗量血小板有效755例(72.1％),无效292例(27.9％).2组患者输注血小板有效率无明显差异(P>0.05).单因素分析均发现2组血小板输注疗效与年龄、血小板输注次数、疾病种类、血小板抗体、输注前白细胞计数有关(P<0.05),而性别、发热、血型与血小板输注疗效无关(P>0.05).多因素分析结果均显示年龄、白细胞计数>50×109/L、血小板输注次数、疾病种类以及血小板抗体是输注无效的独立危险因素(P<0.05).结论 患者输注0.5治疗量或者1治疗量血小板的输注疗效无明显差异.此外,年龄、白细胞计数>50×109/L、血小板输注次数、疾病种类以及血小板抗体是2组患者血小板输注无效的影响因素.
Abstract_FL Objective To compare and analyze the efficacy of platelet transfusion in patients with different doses,and to analyze the risk factors for platelet transfusion refractoriness. Methods A total of 5827 patients who received platelet transfusion in the PLA General Hospital from May 2023 to May 2024 were selected as the research subjects,among which 4780 patients were transfused with 1 therapeutic dose of platelets,and 1047 patients were transfused with 0.5 therapeutic dose of platelets,and the efficacy of platelet transfusion was compared between the two groups. The effects of gender,dis-ease type,white blood cell count before transfusion,fever,number of platelet transfusions,and platelet antibodies on plate-let transfusion refractoriness were analyzed using univariate analysis,and the independent risk factors affecting platelet transfusion refractoriness were further analyzed by multivariate logistic regression. Results Among 4780 patients,3553 (74.3％) were effective and 1227 (25.7％) were ineffective. Among 1047 patients,0.5 platelet infusion was effective in 755 cases (72. 1％) and ineffective in 292 cases (27. 9％). There was no significant difference in the effective rate of platelet transfusion between the two groups (P>0. 05). Univariate analysis showed that the therapeutic effect of platelet transfusion was related to age,the number of platelet transfusion,disease type,platelet antibodies and white blood cell count before transfusion (P<0.05),while age,gender,fever and blood type were not related to the therapeutic effect of platelet transfusion (P>0.05). The results of multi-factor analysis showed that age,white blood cell count>50×109/L,platelet transfusion times,disease type and platelet antibody were independent risk factors for ineffective transfusion(P<0.05). Conclusion There is no significant difference in the efficacy of platelet infusion with 0. 5 therapeutic dose or 1 therapeutic dose. In addition,age,white blood cell count>50×109/L,the number of platelet transfusion,disease type and platelet antibodies were the factors affecting the ineffective platelet transfusion in group 2.
Author 师红梅
于洋
马春娅
朱建玲
付丽辉
程婷婷
AuthorAffiliation 中国人民解放军总医院第一医学中心输血医学科,北京1000853
AuthorAffiliation_xml – name: 中国人民解放军总医院第一医学中心输血医学科,北京1000853
Author_FL FU Lihui
ZHU Jianling
CHENG Tingting
MA Chunya
SHI Hongmei
YU Yang
Author_FL_xml – sequence: 1
  fullname: ZHU Jianling
– sequence: 2
  fullname: CHENG Tingting
– sequence: 3
  fullname: MA Chunya
– sequence: 4
  fullname: FU Lihui
– sequence: 5
  fullname: SHI Hongmei
– sequence: 6
  fullname: YU Yang
Author_xml – sequence: 1
  fullname: 朱建玲
– sequence: 2
  fullname: 程婷婷
– sequence: 3
  fullname: 马春娅
– sequence: 4
  fullname: 付丽辉
– sequence: 5
  fullname: 师红梅
– sequence: 6
  fullname: 于洋
BookMark eNo1jztLA0EcxLeIYIz5HIJw638fd5utRIIvCNgo2IW9V_CQC7iKIZWFaJCECwQVFCUWgqWvQgjql8nexW_hiTrNwG9ghplBhbgZBwjNE8CEMWALEfYidx_vaB1jAsAtm8sWpkA5JhQDiAIq_vPtaVTWOoJcDlAhoYgWx2890--mz6Ps4vLrNJncHZnHJL35zK6OJx-D9OUh5-l5Zzy6N8mZeX8yg565HmavQ9M5SW_7s2gqVLs6KP95CW2tLG9W16zaxup6dalmaQJcWDIQxJOOG4ArpB1SBj6hRNqK8AqTecQqjLpS-EIoL7B9KrnDmAKigtBxPcpKaO6391DFoYob9ah5sBfni_V2Q7fa7Z_DhOZ32Te2w2b5
ClassificationCodes R457.1
ContentType Journal Article
Copyright Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 2B.
4A8
92I
93N
PSX
TCJ
DOI 10.13303/j.cjbt.issn.1004-549x.2024.12.007
DatabaseName Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
DocumentTitle_FL Transfusion efficacy and influencing factors of patients transfused with different therapeutic doses of platelets:a comparative analysis
EndPage 1387
ExternalDocumentID zgsxzz202412007
GroupedDBID -05
2B.
4A8
5XA
5XF
92F
92I
93N
ABJNI
ACGFS
ALMA_UNASSIGNED_HOLDINGS
CCEZO
CIEJG
CW9
GROUPED_DOAJ
PSX
TCJ
TGQ
U1G
U5O
ID FETCH-LOGICAL-s1047-9e71c96be0b795f230d12195a148391c93832b97d77ace5d294633a01aef6bc23
ISSN 1004-549X
IngestDate Thu May 29 04:06:10 EDT 2025
IsPeerReviewed false
IsScholarly true
Issue 12
Keywords 0.5治疗量
platelet transfusion efficacy
0.5 therapeutic dose
多因素分析
1 therapeutic dose
multivariate analysis
1治疗量
血小板输注疗效
Language Chinese
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-s1047-9e71c96be0b795f230d12195a148391c93832b97d77ace5d294633a01aef6bc23
PageCount 5
ParticipantIDs wanfang_journals_zgsxzz202412007
PublicationCentury 2000
PublicationDate 2024-12-01
PublicationDateYYYYMMDD 2024-12-01
PublicationDate_xml – month: 12
  year: 2024
  text: 2024-12-01
  day: 01
PublicationDecade 2020
PublicationTitle 中国输血杂志
PublicationTitle_FL Chinese Journal of Blood Transfusion
PublicationYear 2024
Publisher 中国人民解放军总医院第一医学中心输血医学科,北京1000853
Publisher_xml – name: 中国人民解放军总医院第一医学中心输血医学科,北京1000853
SSID ssj0000602790
ssib001103805
ssib017477180
ssib051369230
Score 2.3748274
Snippet R457.1; 目的 对比分析患者输注不同治疗量血小板的输注疗效,并分析血小板输注无效的危险因素.方法...
SourceID wanfang
SourceType Aggregation Database
StartPage 1383
Title 不同治疗量血小板的输注疗效以及影响因素分析
URI https://d.wanfangdata.com.cn/periodical/zgsxzz202412007
Volume 37
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LaxRBEB5iBPEiiopv9mBfhI3z6J7uPsn0ZpYg6CmB3MI8diIeVsgDwp48iAYxbCCooCjxIHj0dRCC-mcym_gbvFhVMzs7xoWol6G3p7rqq6qdqaqmp9uyroo0SiQUCk2tbN7kPBFNBS_LpqNTlXgJ5OwJzkPeuu3PzPGb82J-4sjP2qql1ZV4KumN_a7kf7wKfeBX_Er2HzxbMYUOaIN_4Qoehutf-ZiFnBnF1DQLBdM2Uy0W-sy4zBgWSqZ9piULNYOCX7VZqFjg4MoGIDY29QDBNDNtIg6Y4khjQqY94uOxQNX4wFUwpUioYYFAPsBEBcQQ-DgEwxviARobhxtODRqrfOIDIux6WlwqEgwHArcRkgo2oVUuiWszXUVQutMq5QM0E6BYFYIlRiQSlVEGSQLNjKwaIxKNHQHZUKtSQRwkRiSkulYl3gpmcT7RcPbE5QdWooxTjyNMROqjM7RDegJIMr3myBVN5iM99ID-hsCDj7GhmQasLunVItDFX8Gu0QiUGPi_SQfDKW-ccf8cJREPAHNb5V38ExDsoOVQFu3VQhouNRKcDiyuYl6x0c7w2XZrEczxioOFymwIfsqxkdaD3IdCbXI3LiRNDSWtTaGlaZa9ONH4wI7mvcXltV4PaZxiJ4ijLtR4bm0-hHJ53Lp_FIygcpaQR1XBRTieD8WJXU2o2r7tSl3sPlJqfMy6NoR6_VCg9NVeN4u6i7UEc_akdaKsDBtB8ZifsiZ6d05bN3a_bOSbTwYfd_aePf_xqL__5n7-vj949X3vxYP9b1uDT--gf_B0fXfnbd5_nH_9kG9t5C-39z5v5-sPB683z1hz7XC2NdMszzxpLtOmKbojnUT7cceOpRYZKJg6kFSIyOFQysAtcI8ba5lKGSUdkbqa-54X2U7Uyfw4cb2z1mT3XrdzzmookUid2VGWyoxHWRwnWZRJmSa4yx1UfeetRqnwQvlOW1444JoLh5NctI6PnqtL1uTK0mrnMuTpK_EV8ucvc0qq8A
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E4%B8%8D%E5%90%8C%E6%B2%BB%E7%96%97%E9%87%8F%E8%A1%80%E5%B0%8F%E6%9D%BF%E7%9A%84%E8%BE%93%E6%B3%A8%E7%96%97%E6%95%88%E4%BB%A5%E5%8F%8A%E5%BD%B1%E5%93%8D%E5%9B%A0%E7%B4%A0%E5%88%86%E6%9E%90&rft.jtitle=%E4%B8%AD%E5%9B%BD%E8%BE%93%E8%A1%80%E6%9D%82%E5%BF%97&rft.au=%E6%9C%B1%E5%BB%BA%E7%8E%B2&rft.au=%E7%A8%8B%E5%A9%B7%E5%A9%B7&rft.au=%E9%A9%AC%E6%98%A5%E5%A8%85&rft.au=%E4%BB%98%E4%B8%BD%E8%BE%89&rft.date=2024-12-01&rft.pub=%E4%B8%AD%E5%9B%BD%E4%BA%BA%E6%B0%91%E8%A7%A3%E6%94%BE%E5%86%9B%E6%80%BB%E5%8C%BB%E9%99%A2%E7%AC%AC%E4%B8%80%E5%8C%BB%E5%AD%A6%E4%B8%AD%E5%BF%83%E8%BE%93%E8%A1%80%E5%8C%BB%E5%AD%A6%E7%A7%91%2C%E5%8C%97%E4%BA%AC1000853&rft.issn=1004-549X&rft.volume=37&rft.issue=12&rft.spage=1383&rft.epage=1387&rft_id=info:doi/10.13303%2Fj.cjbt.issn.1004-549x.2024.12.007&rft.externalDocID=zgsxzz202412007
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzgsxzz%2Fzgsxzz.jpg