白藜芦醇对热应激肉鸡肝脏抗氧化功能和Nrf2通路相关基因表达的影响
S831.5; [目的]本试验旨在研究白藜芦醇对热应激肉鸡肝脏抗氧化功能和核因子E2相关因子2(Nrf2)通路相关基因表达的影响.[方法]300羽1日龄爱拔益加(AA)公鸡饲养至21日龄时选取其中54羽体重相近的肉鸡,随机分为3组,每组3个重复,每个重复6羽.对照组[(22±1)℃,24 h)]和热应激组[(33±1)℃,10 h;(22±1)℃,14 h)]饲喂基础饲粮,热应激+白藜芦醇组饲喂在基础饲粮中添加400 mg?kg-1白藜芦醇的试验饲粮.试验期21 d.[结果]与对照组相比,热应激组肉鸡终末体重、平均日增重(ADG)、平均日采食量(ADFI)、肝脏指数、脾脏指数、胸腺指数、血清中...
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| Published in | 南京农业大学学报 Vol. 44; no. 6; pp. 1154 - 1161 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
安徽农业大学动物科技学院,安徽 合肥230036
2021
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-2030 |
| DOI | 10.7685/jnau.202011015 |
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| Abstract | S831.5; [目的]本试验旨在研究白藜芦醇对热应激肉鸡肝脏抗氧化功能和核因子E2相关因子2(Nrf2)通路相关基因表达的影响.[方法]300羽1日龄爱拔益加(AA)公鸡饲养至21日龄时选取其中54羽体重相近的肉鸡,随机分为3组,每组3个重复,每个重复6羽.对照组[(22±1)℃,24 h)]和热应激组[(33±1)℃,10 h;(22±1)℃,14 h)]饲喂基础饲粮,热应激+白藜芦醇组饲喂在基础饲粮中添加400 mg?kg-1白藜芦醇的试验饲粮.试验期21 d.[结果]与对照组相比,热应激组肉鸡终末体重、平均日增重(ADG)、平均日采食量(ADFI)、肝脏指数、脾脏指数、胸腺指数、血清中葡萄糖(GLU)含量和总蛋白(TP)含量,肝脏中核因子E2相关因子(Nrf2)、亚铁血红素加氧酶(HO-1)、超氧化物歧化酶1(SOD1)mRNA表达量及过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GPX)、谷胱甘肽疏基转移酶(GSH-ST)、SOD活性均显著降低(P<0.05);而料重比(F/G)、血清中谷丙转氨酶(ALT)活性、甘油三酯(TG)和总胆固醇(TC)含量、肝脏中Kelch样环氧氯丙烷相关蛋白1(Keap1)mRNA表达量及丙二醛(MDA)和蛋白质羰基(PC)含量均显著升高(P<0.05).与热应激组相比,热应激+白藜芦醇组肉鸡F/G、血清中ALT活性、肝脏中Keap1 mRNA表达量及MDA含量显著降低(P<0.05);而终末体重,ADG,脾脏指数,胸腺指数,血清中GLU、TP含量,肝脏中Nrf2、HO-1、SOD1 mRNA表达量和GPX、SOD活性显著升高(P<0.05).[结论]白藜芦醇对热应激肉鸡生长性能、免疫器官发育、血清生化指标及抗氧化功能具有促进作用,其改善抗氧化功能的机制可能与其激活Nrf2信号通路有关. |
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| AbstractList | S831.5; [目的]本试验旨在研究白藜芦醇对热应激肉鸡肝脏抗氧化功能和核因子E2相关因子2(Nrf2)通路相关基因表达的影响.[方法]300羽1日龄爱拔益加(AA)公鸡饲养至21日龄时选取其中54羽体重相近的肉鸡,随机分为3组,每组3个重复,每个重复6羽.对照组[(22±1)℃,24 h)]和热应激组[(33±1)℃,10 h;(22±1)℃,14 h)]饲喂基础饲粮,热应激+白藜芦醇组饲喂在基础饲粮中添加400 mg?kg-1白藜芦醇的试验饲粮.试验期21 d.[结果]与对照组相比,热应激组肉鸡终末体重、平均日增重(ADG)、平均日采食量(ADFI)、肝脏指数、脾脏指数、胸腺指数、血清中葡萄糖(GLU)含量和总蛋白(TP)含量,肝脏中核因子E2相关因子(Nrf2)、亚铁血红素加氧酶(HO-1)、超氧化物歧化酶1(SOD1)mRNA表达量及过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GPX)、谷胱甘肽疏基转移酶(GSH-ST)、SOD活性均显著降低(P<0.05);而料重比(F/G)、血清中谷丙转氨酶(ALT)活性、甘油三酯(TG)和总胆固醇(TC)含量、肝脏中Kelch样环氧氯丙烷相关蛋白1(Keap1)mRNA表达量及丙二醛(MDA)和蛋白质羰基(PC)含量均显著升高(P<0.05).与热应激组相比,热应激+白藜芦醇组肉鸡F/G、血清中ALT活性、肝脏中Keap1 mRNA表达量及MDA含量显著降低(P<0.05);而终末体重,ADG,脾脏指数,胸腺指数,血清中GLU、TP含量,肝脏中Nrf2、HO-1、SOD1 mRNA表达量和GPX、SOD活性显著升高(P<0.05).[结论]白藜芦醇对热应激肉鸡生长性能、免疫器官发育、血清生化指标及抗氧化功能具有促进作用,其改善抗氧化功能的机制可能与其激活Nrf2信号通路有关. |
| Author | 王孝成 张成 王驰 赵菲 耿照玉 |
| AuthorAffiliation | 安徽农业大学动物科技学院,安徽 合肥230036 |
| AuthorAffiliation_xml | – name: 安徽农业大学动物科技学院,安徽 合肥230036 |
| Author_FL | ZHAO Fei GENG Zhaoyu WANG Xiaocheng WANG Chi ZHANG Cheng |
| Author_FL_xml | – sequence: 1 fullname: ZHANG Cheng – sequence: 2 fullname: WANG Chi – sequence: 3 fullname: WANG Xiaocheng – sequence: 4 fullname: ZHAO Fei – sequence: 5 fullname: GENG Zhaoyu |
| Author_xml | – sequence: 1 fullname: 张成 – sequence: 2 fullname: 王驰 – sequence: 3 fullname: 王孝成 – sequence: 4 fullname: 赵菲 – sequence: 5 fullname: 耿照玉 |
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| Keywords | 肉鸡;热应激;白藜芦醇;抗氧化能力;血清生化指标 |
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| Snippet | S831.5; [目的]本试验旨在研究白藜芦醇对热应激肉鸡肝脏抗氧化功能和核因子E2相关因子2(Nrf2)通路相关基因表达的影响.[方法]300羽1日龄爱拔益加(AA)公鸡饲养至21日龄时选取其中54羽体重相近的肉鸡,随机分为3组,每组3个重复,每个重复6羽.对照组[(22±1)℃,24... |
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| Title | 白藜芦醇对热应激肉鸡肝脏抗氧化功能和Nrf2通路相关基因表达的影响 |
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