单细胞转录组测序在多发性骨髓瘤诊治和预后中的意义
R857.3%R733.3%R363; 多发性骨髓瘤(multiple myeloma,MM)是一种在临床和生物学都具有异质性的浆细胞恶性肿瘤.尽管进行了广泛的研究,在治疗方面取得了相当大的进展,但疾病的异质性和复发仍然是MM治疗的一大挑战.基于新一代测序的单细胞转录组测序(single-cell transcriptome sequencing,scRNA-seq)技术,能够从单细胞水平探测肿瘤细胞和骨髓微环境的异质性,从而提高我们对MM诊断分层、精确治疗和预后预测的认识.本文就scRNA-seq在MM诊断、治疗及预后中的应用进行综述....
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| Published in | 中国病理生理杂志 Vol. 40; no. 8; pp. 1554 - 1558 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Chinese |
| Published |
甘肃中医药大学第一临床医学院,甘肃 兰州 730030
2024
中国人民解放军联勤保障部队第九四〇医院血液科,甘肃 兰州 730050%甘肃中医药大学第一临床医学院,甘肃 兰州 730030 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-4718 |
| DOI | 10.3969/j.issn.1000-4718.2024.00.019 |
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| Abstract | R857.3%R733.3%R363; 多发性骨髓瘤(multiple myeloma,MM)是一种在临床和生物学都具有异质性的浆细胞恶性肿瘤.尽管进行了广泛的研究,在治疗方面取得了相当大的进展,但疾病的异质性和复发仍然是MM治疗的一大挑战.基于新一代测序的单细胞转录组测序(single-cell transcriptome sequencing,scRNA-seq)技术,能够从单细胞水平探测肿瘤细胞和骨髓微环境的异质性,从而提高我们对MM诊断分层、精确治疗和预后预测的认识.本文就scRNA-seq在MM诊断、治疗及预后中的应用进行综述. |
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| AbstractList | R857.3%R733.3%R363; 多发性骨髓瘤(multiple myeloma,MM)是一种在临床和生物学都具有异质性的浆细胞恶性肿瘤.尽管进行了广泛的研究,在治疗方面取得了相当大的进展,但疾病的异质性和复发仍然是MM治疗的一大挑战.基于新一代测序的单细胞转录组测序(single-cell transcriptome sequencing,scRNA-seq)技术,能够从单细胞水平探测肿瘤细胞和骨髓微环境的异质性,从而提高我们对MM诊断分层、精确治疗和预后预测的认识.本文就scRNA-seq在MM诊断、治疗及预后中的应用进行综述. |
| Abstract_FL | Multiple myeloma(MM)is a plasma cell malignancy that is heterogeneous in both clinical and bio-logical settings.Despite extensive research and considerable progress in treatment,disease heterogeneity and relapse re-main a major challenge in MM treatment.Single-cell transcriptome sequencing(scRNA-seq)technology based on next-generation sequencing can detect the heterogeneity of tumor cells and bone marrow microenvironment at the single-cell level,thereby improving our understanding of MM diagnosis stratification,precise treatment and prognosis prediction.This article reviews the application of scRNA-seq in the diagnosis,treatment and prognosis of MM. |
| Author | 刘文慧 吴涛 |
| AuthorAffiliation | 甘肃中医药大学第一临床医学院,甘肃 兰州 730030;中国人民解放军联勤保障部队第九四〇医院血液科,甘肃 兰州 730050%甘肃中医药大学第一临床医学院,甘肃 兰州 730030 |
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| Author_FL | LIU Wenhui WU Tao |
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| DocumentTitle_FL | Significance of single-cell transcriptome sequencing in diagnosis,treat-ment and prognosis of multiple myeloma |
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| Keywords | microenvironment multiple myeloma 单细胞转录组测序 多发性骨髓瘤 异质性 微环境 single cell transcriptome sequencing heterogeneity |
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| Snippet | R857.3%R733.3%R363; 多发性骨髓瘤(multiple myeloma,MM)是一种在临床和生物学都具有异质性的浆细胞恶性肿瘤.尽管进行了广泛的研究,在治疗方面取得了相当大的进展,但疾病的异质性和复发仍然是MM治疗的一大挑战.基于新一代测序的单细胞转录组测序(single-cell... |
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| Title | 单细胞转录组测序在多发性骨髓瘤诊治和预后中的意义 |
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