妊娠滋养细胞肿瘤合并子宫动静脉畸形与预后相关性分析

R816.91; 目的 通过对比增强磁共振血管成像技术(contrast enhanced-magnetic resonance angiography,CE-MRA)了解妊娠滋养细胞肿瘤(gestational trophoblastic neoplasia,GTN)合并子宫动静脉畸形(uterine arteriovenous malformation,UAVM)与预后的相关性.方法 选取2015年12月至2020年12月在复旦大学附属妇产科医院就诊的、疑诊GTN的患者,在治疗前行磁共振常规扫描和CE-MRA扫描,对所有病例进行国际妇产科学联合会(International Federat...

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Published in复旦学报（医学版） Vol. 51; no. 3; pp. 315 - 322
Main Authors 周清, 刘源涛, 马凤华, 鹿欣, 张鹤, 张国福
Format Journal Article
LanguageChinese
Published 复旦大学附属妇产科医院放射科 上海 200011%复旦大学附属妇产科医院妇科 上海 200011 30.05.2024
Subjects
gestational trophoblastic neoplasia(GTN)
magnetic resonance imaging
contrast-enhanced magnetic resonance angiography(CE-MRA)
子宫动静脉畸形(UAVM)
对比增强磁共振血管成像技术(CE-MRA)
妊娠滋养细胞肿瘤(GTN)
磁共振成像技术
uterine arteriovenous malformation(UVAM)
Online AccessGet full text
ISSN1672-8467
DOI10.3969/j.issn.1672-8467.2024.03.004

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Abstract R816.91; 目的 通过对比增强磁共振血管成像技术(contrast enhanced-magnetic resonance angiography,CE-MRA)了解妊娠滋养细胞肿瘤(gestational trophoblastic neoplasia,GTN)合并子宫动静脉畸形(uterine arteriovenous malformation,UAVM)与预后的相关性.方法 选取2015年12月至2020年12月在复旦大学附属妇产科医院就诊的、疑诊GTN的患者,在治疗前行磁共振常规扫描和CE-MRA扫描,对所有病例进行国际妇产科学联合会(International Federation of Gynecology and Obstetrics,FIGO)分期和预后评分.对患者的治疗方式(化疗、手术治疗、动脉栓塞治疗)及预后进行记录.结果 共纳入 44例GTN患者,包括 5例胎盘部位滋养层肿瘤(placental site trophoblastic tumor,PSTT)和 39例其他GTN.PSTT合并UAVM 3例,GTN合并UAVM 23例.根据UAVM的存在与否,将 39例其他GTN患者分为两组.对人绒毛膜促性腺激素(β-human chorionic gonadotropin,β-hCG)值＜10 000 mIU/mL和≥10 000 mIU/mL的数据进行四格表χ2 检验,差异有统计学意义(P=0.001).两组病例的FIGO预后评分平均为(4.19±3.69)分和(6.70±3.39)分,差异有统计学意义(P=0.035).结论 当β-hCG值≥10 000 mIU/mL时,UAVM发生概率增加.预后评分越高,发生UAVM的可能性就越大.运用CE-MRA技术有助于更好地诊断UAVM.
AbstractList R816.91; 目的 通过对比增强磁共振血管成像技术(contrast enhanced-magnetic resonance angiography,CE-MRA)了解妊娠滋养细胞肿瘤(gestational trophoblastic neoplasia,GTN)合并子宫动静脉畸形(uterine arteriovenous malformation,UAVM)与预后的相关性.方法 选取2015年12月至2020年12月在复旦大学附属妇产科医院就诊的、疑诊GTN的患者,在治疗前行磁共振常规扫描和CE-MRA扫描,对所有病例进行国际妇产科学联合会(International Federation of Gynecology and Obstetrics,FIGO)分期和预后评分.对患者的治疗方式(化疗、手术治疗、动脉栓塞治疗)及预后进行记录.结果 共纳入 44例GTN患者,包括 5例胎盘部位滋养层肿瘤(placental site trophoblastic tumor,PSTT)和 39例其他GTN.PSTT合并UAVM 3例,GTN合并UAVM 23例.根据UAVM的存在与否,将 39例其他GTN患者分为两组.对人绒毛膜促性腺激素(β-human chorionic gonadotropin,β-hCG)值＜10 000 mIU/mL和≥10 000 mIU/mL的数据进行四格表χ2 检验,差异有统计学意义(P=0.001).两组病例的FIGO预后评分平均为(4.19±3.69)分和(6.70±3.39)分,差异有统计学意义(P=0.035).结论 当β-hCG值≥10 000 mIU/mL时,UAVM发生概率增加.预后评分越高,发生UAVM的可能性就越大.运用CE-MRA技术有助于更好地诊断UAVM.
Abstract_FL Objective To investigated vascular characteristics and clinical follow-up results of gestational trophoblastic neoplasia(GTN)with uterine arteriovenous malformation(UAVM)using contrast-enhanced magnetic resonance angiography(CE-MRA).Methods Patients clinically suspected of GTN at Obstetrics and Gynecology Hospital,Fudan University from Dec 2015 to Dec 2020 were selected.Imaging characteristics of conventional magnetic resonance imaging and CE-MRA before treatment.The International Federation of Gynecology and Obstetrics(FIGO)2000 clinical staging and prognosis scoring system was used to evaluate the severity of the condition and related risk factors,the treatment methods(chemotherapy,surgical treatment,and arterial embolization)and prognosis determined during follow-up were recorded.Results A total of 44 cases were included,including 5 cases of placental site trophoblastic tumor(PSTT)and 39 cases of the other GTN.There were 3 cases of PSTT combined with UAVM and 23 cases of the other GTN combined with UAVM.Thirty-nine cases of the other GTN were divided into two groups according to the presence or absence of UAVM.Data regarding the β-human chorionic gonadotropin(β-hCG)value(＜10 000 mIU/mL and≥10 000 mIU/mL)were evaluated using Chi-square test,and the difference was statistically significant(P=0.001).The average FIGO scores of the two groups were 4.19±3.69 and 6.70±3.39,and the difference was statistically significant(P=0.035).Conclusion When β-hCG value≥10 000 mIU/mL,the probability of UAVM occurrence increases.The higher the prognosis score is,the more possibility of formation of UAVM.The use of CE-MRA technology helps to better diagnose UAVM.
Author 张鹤
刘源涛
张国福
马凤华
周清
鹿欣
AuthorAffiliation 复旦大学附属妇产科医院放射科 上海 200011%复旦大学附属妇产科医院妇科 上海 200011
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Author_FL MA Feng-hua
ZHANG He
ZHOU Qing
LU Xin
ZHANG Guo-fu
LIU Yuan-tao
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Keywords gestational trophoblastic neoplasia(GTN)
magnetic resonance imaging
contrast-enhanced magnetic resonance angiography(CE-MRA)
子宫动静脉畸形(UAVM)
对比增强磁共振血管成像技术(CE-MRA)
妊娠滋养细胞肿瘤(GTN)
磁共振成像技术
uterine arteriovenous malformation(UVAM)
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Snippet R816.91; 目的 通过对比增强磁共振血管成像技术(contrast enhanced-magnetic resonance angiography,CE-MRA)了解妊娠滋养细胞肿瘤(gestational trophoblastic neoplasia,GTN)合并子宫动静脉畸形(uterine...
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StartPage 315
Title 妊娠滋养细胞肿瘤合并子宫动静脉畸形与预后相关性分析
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