褪黑素联合亚低温治疗新生儿缺氧缺血性脑病的研究进展
新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)是足月儿死亡和远期神经发育障碍的主要病因之一,尚无根治措施.亚低温治疗(therapeutic hypothermia,TH)是新生儿监护病房中HIE的标准疗法,但在偏远地区的安全性和有效性尚不确定.褪黑素(melatonin,MT)是一种主要由松果体分泌的吲哚类内分泌激素,能够轻易穿透血脑屏障.通过受体和非受体机制,MT发挥抗氧化、抗炎效果,参与调控细胞器功能、抑制细胞死亡.可靠的安全性及临床(前)结果使MT被认为是治疗HIE有前景的药物之一.该文就MT联合TH治疗HIE的研究进展进行综述....
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| Published in | 中国当代儿科杂志 Vol. 25; no. 8; pp. 864 - 869 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
华中科技大学同济医学院附属湖北妇幼保健院新生儿科,湖北武汉 430070
01.08.2023
武汉科技大学医学院,湖北武汉 430065 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-8830 |
| DOI | 10.7499/j.issn.1008-8830.2302099 |
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| Abstract | 新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)是足月儿死亡和远期神经发育障碍的主要病因之一,尚无根治措施.亚低温治疗(therapeutic hypothermia,TH)是新生儿监护病房中HIE的标准疗法,但在偏远地区的安全性和有效性尚不确定.褪黑素(melatonin,MT)是一种主要由松果体分泌的吲哚类内分泌激素,能够轻易穿透血脑屏障.通过受体和非受体机制,MT发挥抗氧化、抗炎效果,参与调控细胞器功能、抑制细胞死亡.可靠的安全性及临床(前)结果使MT被认为是治疗HIE有前景的药物之一.该文就MT联合TH治疗HIE的研究进展进行综述. |
|---|---|
| AbstractList | 新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)是足月儿死亡和远期神经发育障碍的主要病因之一,尚无根治措施.亚低温治疗(therapeutic hypothermia,TH)是新生儿监护病房中HIE的标准疗法,但在偏远地区的安全性和有效性尚不确定.褪黑素(melatonin,MT)是一种主要由松果体分泌的吲哚类内分泌激素,能够轻易穿透血脑屏障.通过受体和非受体机制,MT发挥抗氧化、抗炎效果,参与调控细胞器功能、抑制细胞死亡.可靠的安全性及临床(前)结果使MT被认为是治疗HIE有前景的药物之一.该文就MT联合TH治疗HIE的研究进展进行综述. |
| Author | 刘一勋 |
| AuthorAffiliation | 武汉科技大学医学院,湖北武汉 430065;华中科技大学同济医学院附属湖北妇幼保健院新生儿科,湖北武汉 430070 |
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| Author_FL | LIU Yi-Xun |
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| Keywords | 治疗 Melatonin Treatment Neonate 缺氧缺血性脑病 新生儿 Hypoxic-ischemic encephalopathy 褪黑素 |
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| Title | 褪黑素联合亚低温治疗新生儿缺氧缺血性脑病的研究进展 |
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