溶质载体家族3成员2表达与双硫死亡、铁死亡及肿瘤关系的研究进展
Q255%R73-3%R363; 铁死亡和双硫死亡与多种疾病相关.铁死亡的特征是铁离子和脂质活性氧的异常累积,而双硫死亡则是二硫化物的异常累积.溶质载体家族3成员2(SLC3A2)作为溶质载体家族的一员,不仅参与调控肿瘤细胞的增殖、迁移、侵袭和凋亡,还参与细胞铁死亡和双硫死亡,在肿瘤的发生发展中起关键作用.本文阐述了SLC3A2与双硫死亡、铁死亡和肿瘤关系的研究进展,旨在为癌症靶向治疗提供理论基础....
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| Published in | 中国病理生理杂志 Vol. 40; no. 9; pp. 1772 - 1776 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
甘肃中医药大学第一临床医学院,甘肃 兰州 730000%甘肃省人民医院超声医学科,甘肃 兰州 730000
2024
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-4718 |
| DOI | 10.3969/j.issn.1000-4718.2024.00.024 |
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| Abstract | Q255%R73-3%R363; 铁死亡和双硫死亡与多种疾病相关.铁死亡的特征是铁离子和脂质活性氧的异常累积,而双硫死亡则是二硫化物的异常累积.溶质载体家族3成员2(SLC3A2)作为溶质载体家族的一员,不仅参与调控肿瘤细胞的增殖、迁移、侵袭和凋亡,还参与细胞铁死亡和双硫死亡,在肿瘤的发生发展中起关键作用.本文阐述了SLC3A2与双硫死亡、铁死亡和肿瘤关系的研究进展,旨在为癌症靶向治疗提供理论基础. |
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| AbstractList | Q255%R73-3%R363; 铁死亡和双硫死亡与多种疾病相关.铁死亡的特征是铁离子和脂质活性氧的异常累积,而双硫死亡则是二硫化物的异常累积.溶质载体家族3成员2(SLC3A2)作为溶质载体家族的一员,不仅参与调控肿瘤细胞的增殖、迁移、侵袭和凋亡,还参与细胞铁死亡和双硫死亡,在肿瘤的发生发展中起关键作用.本文阐述了SLC3A2与双硫死亡、铁死亡和肿瘤关系的研究进展,旨在为癌症靶向治疗提供理论基础. |
| Abstract_FL | Ferroptosis and disulfidpthosis are associated with various diseases.Ferroptosis is distinguished by abnormal accumulation of iron ions and lipid reactive oxygen species,while disulfidptosis is marked by abnormal accumu-lation of disulfides.Solute carrier family 3 member 2(SLC3A2),a component of the solute carrier family,is implicated not only involved in the regulation of tumor cell proliferation,migration,invasion and apoptosis,but also in the processes of ferroptosis and disulfidptosis,playing a pivotal role in tumor growth and progression.This article provides an overview of the latest advancements in understanding the relationship between SLC3A2 and ferroptosis,disulfidptosis and tumors,aiming to establish a theoretical basis for targeted cancer therapies. |
| Author | 代九菊 周祖邦 马欢 杨艳丽 |
| AuthorAffiliation | 甘肃中医药大学第一临床医学院,甘肃 兰州 730000%甘肃省人民医院超声医学科,甘肃 兰州 730000 |
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| Author_FL | YANG Yanli ZHOU Zubang DAI Jiuju MA Huan |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| DOI | 10.3969/j.issn.1000-4718.2024.00.024 |
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| DocumentTitle_FL | Progress in relationship between expression of solute carrier family 3 member 2,and disulfidptosis,ferroptosis and tumors |
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| Issue | 9 |
| Keywords | ferroptosis 肿瘤 tumor solute carrier family 3 member 2 铁死亡 双硫死亡 disulfidptosis 溶质载体家族3成员2 |
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| PublicationYear | 2024 |
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| Title | 溶质载体家族3成员2表达与双硫死亡、铁死亡及肿瘤关系的研究进展 |
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