培哚普利通过调控脑锌代谢改善APP/PS1转基因小鼠认知功能

R322.81; 目的 探讨培哚普利对APP/PS1转基因小鼠认知功能和大脑皮层锌、铁、锰、铜、镁、钙水平,以及锌转运体家族成员(ZnT1、ZnT2、ZnT3、ZnT4、ZnT5、ZnT6、ZnTT) mRNA表达水平的影响.方法 10只APP/PS1转基因小鼠随机分为对照组和培哚普利治疗组(各5只).应用水迷宫实验检测小鼠认知功能;应用电感耦合等离子体质谱(inductively coupled plasma mass spectrometry,ICP-MS)检测小鼠大脑皮层6种金属微量元素的含量;应用real-time PCR检测小鼠大脑皮层锌转运体家族成员mRNA表达水平.结果 培哚普利...

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Published in复旦学报（医学版） Vol. 46; no. 4; pp. 454 - 484
Main Authors 张振博, 李怡君, 陈靖毅, 王顺, 崔安凤, 向萌, 杨叶虹, 张丽红
Format Journal Article
LanguageChinese
Published 复旦大学基础医学院解剖与组织胚胎学系 上海200032%复旦大学基础医学院生理与病理生理学系 上海200032%复旦大学附属华山医院内分泌科 上海200040 25.07.2019
Subjects
APP/PS1转基因小鼠
培哚普利
锌
大脑皮层
锌转运体
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ISSN1672-8467
DOI10.3969/j.issn.1672-8467.2019.04.004

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Abstract R322.81; 目的 探讨培哚普利对APP/PS1转基因小鼠认知功能和大脑皮层锌、铁、锰、铜、镁、钙水平,以及锌转运体家族成员(ZnT1、ZnT2、ZnT3、ZnT4、ZnT5、ZnT6、ZnTT) mRNA表达水平的影响.方法 10只APP/PS1转基因小鼠随机分为对照组和培哚普利治疗组(各5只).应用水迷宫实验检测小鼠认知功能;应用电感耦合等离子体质谱(inductively coupled plasma mass spectrometry,ICP-MS)检测小鼠大脑皮层6种金属微量元素的含量;应用real-time PCR检测小鼠大脑皮层锌转运体家族成员mRNA表达水平.结果 培哚普利降低了APP/PS1转基因小鼠逃避潜伏期,增加了小鼠穿越平台次数;培哚普利增加了APP/PS1转基因小鼠大脑皮层锌水平,而铁、锰、铜、镁、钙水平在培哚普利应用前后未见显著性差异;培哚普利降低了锌转运体家族成员中ZnT1的mRNA表达水平,而ZnT2、ZnT3、ZnT4、ZnT5、ZnT6、ZnT7的表达水平在培哚普利应用前后未见显著性差异.结论 培哚普利可以通过下调大脑皮层ZnT1表达,调控脑锌代谢,进而改善APP/PS1转基因小鼠认知功能,提示调控脑内锌稳态是培哚普利改善阿尔茨海默病(Alzheimer's disease,AD)认知水平的重要机制之一.
AbstractList R322.81; 目的 探讨培哚普利对APP/PS1转基因小鼠认知功能和大脑皮层锌、铁、锰、铜、镁、钙水平,以及锌转运体家族成员(ZnT1、ZnT2、ZnT3、ZnT4、ZnT5、ZnT6、ZnTT) mRNA表达水平的影响.方法 10只APP/PS1转基因小鼠随机分为对照组和培哚普利治疗组(各5只).应用水迷宫实验检测小鼠认知功能;应用电感耦合等离子体质谱(inductively coupled plasma mass spectrometry,ICP-MS)检测小鼠大脑皮层6种金属微量元素的含量;应用real-time PCR检测小鼠大脑皮层锌转运体家族成员mRNA表达水平.结果 培哚普利降低了APP/PS1转基因小鼠逃避潜伏期,增加了小鼠穿越平台次数;培哚普利增加了APP/PS1转基因小鼠大脑皮层锌水平,而铁、锰、铜、镁、钙水平在培哚普利应用前后未见显著性差异;培哚普利降低了锌转运体家族成员中ZnT1的mRNA表达水平,而ZnT2、ZnT3、ZnT4、ZnT5、ZnT6、ZnT7的表达水平在培哚普利应用前后未见显著性差异.结论 培哚普利可以通过下调大脑皮层ZnT1表达,调控脑锌代谢,进而改善APP/PS1转基因小鼠认知功能,提示调控脑内锌稳态是培哚普利改善阿尔茨海默病(Alzheimer's disease,AD)认知水平的重要机制之一.
Author 陈靖毅
王顺
向萌
杨叶虹
李怡君
崔安凤
张振博
张丽红
AuthorAffiliation 复旦大学基础医学院解剖与组织胚胎学系 上海200032%复旦大学基础医学院生理与病理生理学系 上海200032%复旦大学附属华山医院内分泌科 上海200040
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Author_FL YANG Ye-hong
LI Yi-jun
CUI An-feng
CHAN Jin-ei
ZHANG Li-hong
ZHANG Zhen-bo
XIANG Meng
WANG Shun
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DocumentTitle_FL The ameliorating effects of perindopril on cognitive function of APP/PS1 transgenic mouse via zinc regulation in cerebral cortex
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Keywords APP/PS1转基因小鼠
培哚普利
锌
大脑皮层
锌转运体
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Snippet R322.81; 目的 探讨培哚普利对APP/PS1转基因小鼠认知功能和大脑皮层锌、铁、锰、铜、镁、钙水平,以及锌转运体家族成员(ZnT1、ZnT2、ZnT3、ZnT4、ZnT5、ZnT6、ZnTT) mRNA表达水平的影响.方法...
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StartPage 454
Title 培哚普利通过调控脑锌代谢改善APP/PS1转基因小鼠认知功能
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