B淋系/髓系混合表型急性白血病伴TEL-ABL1融合基因表达1例

R733.71; 混合表型急性白血病(mixed phenotype acute leukemia,MPAL)临床罕见,约占急性白血病的2％～5％.TEL-ABL1融合基因阳性主要见于急性髓细胞白血病(acute myeloid leukemia,AML)、急性淋巴细胞白血病(acute lymphocytic leukemia,ALL)、骨髓增殖性肿瘤(myeloproliferative neoplasm,MPN)等恶性血液系统肿瘤,目前以病例报道为主,均提示预后不良.本例患者B淋系/髓系MPAL伴TEL-ABL1融合基因阳性为首次报道,我们给予针对淋系、髓系白血病化学治疗及酪氨酸激酶抑制...

Full description

Saved in:
Bibliographic Details
Published in复旦学报（医学版） Vol. 49; no. 4; pp. 628 - 632
Main Authors 王露婷, 陆丽娜, 何大保, 刘小敏, 曹淑雅, 王素云
Format Journal Article
LanguageChinese
Published 深圳市龙华区中心医院血液内科 深圳 518110%深圳市龙华区中心医院检验科 深圳 518110 01.07.2022
Subjects
混合表型急性白血病(MPAL)
TEL-ABL1
B淋系/髓系
Online AccessGet full text
ISSN1672-8467
DOI10.3969/j.issn.1672-8467.2022.04.022

Cover

Abstract R733.71; 混合表型急性白血病(mixed phenotype acute leukemia,MPAL)临床罕见,约占急性白血病的2％～5％.TEL-ABL1融合基因阳性主要见于急性髓细胞白血病(acute myeloid leukemia,AML)、急性淋巴细胞白血病(acute lymphocytic leukemia,ALL)、骨髓增殖性肿瘤(myeloproliferative neoplasm,MPN)等恶性血液系统肿瘤,目前以病例报道为主,均提示预后不良.本例患者B淋系/髓系MPAL伴TEL-ABL1融合基因阳性为首次报道,我们给予针对淋系、髓系白血病化学治疗及酪氨酸激酶抑制剂靶向治疗后,达到完全缓解,经巩固化疗后进行人类白细胞抗原(human leucocyte antigen,HLA)相合同胞间异基因外周血造血干细胞移植,患者后因肠道排异反应死亡.
AbstractList R733.71; 混合表型急性白血病(mixed phenotype acute leukemia,MPAL)临床罕见,约占急性白血病的2％～5％.TEL-ABL1融合基因阳性主要见于急性髓细胞白血病(acute myeloid leukemia,AML)、急性淋巴细胞白血病(acute lymphocytic leukemia,ALL)、骨髓增殖性肿瘤(myeloproliferative neoplasm,MPN)等恶性血液系统肿瘤,目前以病例报道为主,均提示预后不良.本例患者B淋系/髓系MPAL伴TEL-ABL1融合基因阳性为首次报道,我们给予针对淋系、髓系白血病化学治疗及酪氨酸激酶抑制剂靶向治疗后,达到完全缓解,经巩固化疗后进行人类白细胞抗原(human leucocyte antigen,HLA)相合同胞间异基因外周血造血干细胞移植,患者后因肠道排异反应死亡.
Author 陆丽娜
王露婷
曹淑雅
王素云
刘小敏
何大保
AuthorAffiliation 深圳市龙华区中心医院血液内科 深圳 518110%深圳市龙华区中心医院检验科 深圳 518110
AuthorAffiliation_xml – name: 深圳市龙华区中心医院血液内科 深圳 518110%深圳市龙华区中心医院检验科 深圳 518110
Author_FL WANG Su-yun
LU Li-na
CAO Shu-ya
HE Da-bao
LIU Xiao-min
WANG Lu-ting
Author_FL_xml – sequence: 1
  fullname: WANG Lu-ting
– sequence: 2
  fullname: LU Li-na
– sequence: 3
  fullname: HE Da-bao
– sequence: 4
  fullname: LIU Xiao-min
– sequence: 5
  fullname: CAO Shu-ya
– sequence: 6
  fullname: WANG Su-yun
Author_xml – sequence: 1
  fullname: 王露婷
– sequence: 2
  fullname: 陆丽娜
– sequence: 3
  fullname: 何大保
– sequence: 4
  fullname: 刘小敏
– sequence: 5
  fullname: 曹淑雅
– sequence: 6
  fullname: 王素云
BookMark eNo9j0tLw0AAhPdQwVr7L7x4yHZfSXaPbakvAl7queSxq62SgotYb7kIQhAKHkSEag-i4FEh4CO_pnn4L4woXuaDYZhhVkAtHIcSgDWMIBWWaI3gUOsQYssmBmeWDQkiBCIGK9RA_d9fBk2thx5CBFFhU1IHO508iYuX99bX81WFPEmy6UU5f8pmcR495NFjcfNZzqPi-nzx8drvOUa74-Bydlmlsru37Pa-ypZpihdpvAqWlHukZfOPDbC30et3twxnd3O723YMjREjhsJmYEnXpqZAmHGTcF95QjLOg0BRaRJfYEZtpmiAXJNQyxcWEYpzLJSUZkAbYP2399QNlRvuD0bjk-OwWhzog7PDYDLxft4jVgn9BrREaYM
ClassificationCodes R733.71
ContentType Journal Article
Copyright Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 2B.
4A8
92I
93N
PSX
TCJ
DOI 10.3969/j.issn.1672-8467.2022.04.022
DatabaseName Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
DocumentTitle_FL Mixed phenotype(B-lymphocytic/myeloid)acute leukemia with expression of TEL-ABL1 fusion gene:a case report
EndPage 632
ExternalDocumentID shykdxxb202204022
GrantInformation_xml – fundername: (深圳市科技创新委员会科技计划); (广东省深圳市龙华区医疗卫生机构科研项目)
  funderid: (深圳市科技创新委员会科技计划); (广东省深圳市龙华区医疗卫生机构科研项目)
GroupedDBID -05
2B.
4A8
5XA
5XF
92F
92I
93N
ABDBF
ACUHS
ALMA_UNASSIGNED_HOLDINGS
CCEZO
CIEJG
DIK
PSX
TCJ
TGQ
U1G
U5O
ID FETCH-LOGICAL-s1042-f15d6ea73590148528cfb9e488ddf3e52c914374f3d0a5236c9629f8819fee5d3
ISSN 1672-8467
IngestDate Thu May 29 04:01:16 EDT 2025
IsPeerReviewed false
IsScholarly true
Issue 4
Keywords 混合表型急性白血病(MPAL)
TEL-ABL1
B淋系/髓系
Language Chinese
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-s1042-f15d6ea73590148528cfb9e488ddf3e52c914374f3d0a5236c9629f8819fee5d3
PageCount 5
ParticipantIDs wanfang_journals_shykdxxb202204022
PublicationCentury 2000
PublicationDate 2022-07-01
PublicationDateYYYYMMDD 2022-07-01
PublicationDate_xml – month: 07
  year: 2022
  text: 2022-07-01
  day: 01
PublicationDecade 2020
PublicationTitle 复旦学报（医学版）
PublicationTitle_FL Fudan University Journal of Medical Sciences
PublicationYear 2022
Publisher 深圳市龙华区中心医院血液内科 深圳 518110%深圳市龙华区中心医院检验科 深圳 518110
Publisher_xml – name: 深圳市龙华区中心医院血液内科 深圳 518110%深圳市龙华区中心医院检验科 深圳 518110
SSID ssib002039732
ssib036437206
ssib051371206
ssj0001844257
ssib002423895
ssib038076145
ssib002805881
ssib006704044
ssib001104042
ssib005319430
Score 2.2999487
Snippet R733.71; 混合表型急性白血病(mixed phenotype acute leukemia,MPAL)临床罕见,约占急性白血病的2％～5％.TEL-ABL1融合基因阳性主要见于急性髓细胞白血病(acute myeloid leukemia,AML)、急性淋巴细胞白血病(acute lymphocytic...
SourceID wanfang
SourceType Aggregation Database
StartPage 628
Title B淋系/髓系混合表型急性白血病伴TEL-ABL1融合基因表达1例
URI https://d.wanfangdata.com.cn/periodical/shykdxxb202204022
Volume 49
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR1Na9RANJQWxIsoKn5TpHMq2yYzmcnMcWY3SynVUwu9lWSTWBBXsC3UnnoRhCIIHkSEag-i4FGh4Ed_TXe7_gvfm2Q3QytaBWHJzr558z6z894k8-F5U2kisgIGOA0ZFDhACURD0pQ2Cp6opKPSgttNfe7cFXNL4fwyXx4bf-DMWtpYT2c6W79cV_IvXgUY-BVXyf6FZ0dEAQBl8C9cwcNwPZWPDYkFMRGRUIiIYcQYIEZiRbQhitXAEg0-MSfKJ1KSWBIdEC0tJLYUBM560HxYiLC5UsS0KmQAIgTYAU5ITJOYcDFeaGizECAKkmk5HKDQJkbbgiHad3hKYmL4BJYOcndzZGygQ0tLIDstLKRlCyCbtkK2UYCSjWxaHUc4IKGyVSXO6FGHrSl1VURBI2obgYpRjaJQZymsZNIqz1Fk1axRQgQrXsmJhgJIm6hWjcKRv7LSGbBG26oCwLb7lIXWM3LL_8XQT4G1WROdhwQkkRQFA0uBbEi7hXpUmutKVG1FBTkkc4xi1dHUcSGwEJXqoCb6MkIdVDB9kv00h9Qs8Anl_1M0QTSzosFPjbV_lsiJpSKCYBuWp60Mg225P23VqYRO5BTVHgFlEibKh97H4ztTQtn4jgxmRgxm0GN2x-JyjfuxHdTXVh_fzzY3U8SCmEUhY5ugUYSzOia0aZl2PX4IoD50phn4DHezcvNZSPCd8YX0uXscAwY09zgDESG9UcBj9i15Pa0BD3sQzmt9HrAoGNbbh8QyDMvdike6nvGmKkPM_s4Mdg1it0i695x0efG8d64a507qstO64I1trV705k1_f-fo09fZHx9fwFd_f7_3_Olg70Nvd6e__a6__f7o1ffB3vbRyyeH3z4Pu5bB7jPA6r350nv9FnAHBwfB4cHOJW-pHS825xrVYS6NtQCXABYBz0SeRAwXu4eSU9kpUpVD_pBlBcs57SgYukVhwTI_geAhOkpQVYB1VZHnPGOXvfHuw25-xZtkBWdJmnOwVQK5NVU-7cgUGlABg48iverdrnRfqTrrtZUT98C10yBd987WncENb3z90UZ-EwYh6-mt6tb5CSnt2j0
linkProvider EBSCOhost
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=B%E6%B7%8B%E7%B3%BB%2F%E9%AB%93%E7%B3%BB%E6%B7%B7%E5%90%88%E8%A1%A8%E5%9E%8B%E6%80%A5%E6%80%A7%E7%99%BD%E8%A1%80%E7%97%85%E4%BC%B4TEL-ABL1%E8%9E%8D%E5%90%88%E5%9F%BA%E5%9B%A0%E8%A1%A8%E8%BE%BE1%E4%BE%8B&rft.jtitle=%E5%A4%8D%E6%97%A6%E5%AD%A6%E6%8A%A5%EF%BC%88%E5%8C%BB%E5%AD%A6%E7%89%88%EF%BC%89&rft.au=%E7%8E%8B%E9%9C%B2%E5%A9%B7&rft.au=%E9%99%86%E4%B8%BD%E5%A8%9C&rft.au=%E4%BD%95%E5%A4%A7%E4%BF%9D&rft.au=%E5%88%98%E5%B0%8F%E6%95%8F&rft.date=2022-07-01&rft.pub=%E6%B7%B1%E5%9C%B3%E5%B8%82%E9%BE%99%E5%8D%8E%E5%8C%BA%E4%B8%AD%E5%BF%83%E5%8C%BB%E9%99%A2%E8%A1%80%E6%B6%B2%E5%86%85%E7%A7%91+%E6%B7%B1%E5%9C%B3+518110%25%E6%B7%B1%E5%9C%B3%E5%B8%82%E9%BE%99%E5%8D%8E%E5%8C%BA%E4%B8%AD%E5%BF%83%E5%8C%BB%E9%99%A2%E6%A3%80%E9%AA%8C%E7%A7%91+%E6%B7%B1%E5%9C%B3+518110&rft.issn=1672-8467&rft.volume=49&rft.issue=4&rft.spage=628&rft.epage=632&rft_id=info:doi/10.3969%2Fj.issn.1672-8467.2022.04.022&rft.externalDocID=shykdxxb202204022
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fshykdxxb%2Fshykdxxb.jpg