姜酚和百里香酚对白羽肉鸡小肠形态结构和屏障功能的影响
S831.5; [目的]本试验旨在研究日粮添加姜酚、百里香酚及其组合对白羽肉鸡小肠形态、免疫功能及肠道屏障的影响.[方法]将200只1日龄AA白羽肉鸡随机分为4组,每组5个重复,每个重复10只,试验期为42 d.4个处理组如下:对照组(Con组,基础日粮)、姜酚组(Gin组,基础日粮+60 mg·kg-1姜酚)、百里香酚组(Thy组,基础日粮+30 mg·kg-1百里香酚)及姜百组(Gin+ Thy组,基础日粮+30 mg·kg-1姜酚+15 mg·kg-1百里香酚).在试验期第 42 天,采集肉鸡的空肠和回肠制作切片并观察,取空肠和回肠黏膜以测定免疫球蛋白含量、细胞因子含量、抗氧化酶活性、紧...
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| Published in | 南京农业大学学报 Vol. 47; no. 1; pp. 87 - 95 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
南京农业大学动物科技学院/国家动物消化道营养国际联合研究中心,江苏 南京 210095
2024
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-2030 |
| DOI | 10.7685/jnau.202209017 |
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| Abstract | S831.5; [目的]本试验旨在研究日粮添加姜酚、百里香酚及其组合对白羽肉鸡小肠形态、免疫功能及肠道屏障的影响.[方法]将200只1日龄AA白羽肉鸡随机分为4组,每组5个重复,每个重复10只,试验期为42 d.4个处理组如下:对照组(Con组,基础日粮)、姜酚组(Gin组,基础日粮+60 mg·kg-1姜酚)、百里香酚组(Thy组,基础日粮+30 mg·kg-1百里香酚)及姜百组(Gin+ Thy组,基础日粮+30 mg·kg-1姜酚+15 mg·kg-1百里香酚).在试验期第 42 天,采集肉鸡的空肠和回肠制作切片并观察,取空肠和回肠黏膜以测定免疫球蛋白含量、细胞因子含量、抗氧化酶活性、紧密连接和抗氧化相关基因表达.[结果]与对照组相比,姜百组肉鸡回肠绒毛高度(VH)有增加的趋势(P=0.063),绒毛高度/隐窝深度(V/C)值显著提高(P<0.05);姜百组肉鸡空肠和回肠黏膜中分泌性免疫球蛋白A(sIgA)含量显著提高(P<0.05),空肠黏膜中白介素6(IL-6)和干扰素γ(IFN-γ)含量以及回肠黏膜中IL-6和白介素1β(IL-1β)含量显著降低(P<0.05);姜百组肉鸡空肠和回肠黏膜中总抗氧化能力(T-AOC)和谷胱甘肽过氧化物酶(GSH-Px)活性显著升高(P<0.05);姜百组肉鸡空肠黏膜中核因子E2 相关因子 2(Nrf2)、血红素加氧酶 1(HO-1)、谷胱甘肽过氧化物酶(GPX4)和回肠黏膜中Nrf2、超氧化物歧化酶 1(SOD1)、GPX4 的mRNA相对表达量显著升高(P<0.05),空肠和回肠黏膜中的Occludin mRNA相对表达量显著增加(P<0.05).[结论]日粮添加姜酚和百里香酚组合可以提高肉鸡的抗氧化能力和免疫功能,并通过改善肠道形态和肠道屏障促进肠道健康. |
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| AbstractList | S831.5; [目的]本试验旨在研究日粮添加姜酚、百里香酚及其组合对白羽肉鸡小肠形态、免疫功能及肠道屏障的影响.[方法]将200只1日龄AA白羽肉鸡随机分为4组,每组5个重复,每个重复10只,试验期为42 d.4个处理组如下:对照组(Con组,基础日粮)、姜酚组(Gin组,基础日粮+60 mg·kg-1姜酚)、百里香酚组(Thy组,基础日粮+30 mg·kg-1百里香酚)及姜百组(Gin+ Thy组,基础日粮+30 mg·kg-1姜酚+15 mg·kg-1百里香酚).在试验期第 42 天,采集肉鸡的空肠和回肠制作切片并观察,取空肠和回肠黏膜以测定免疫球蛋白含量、细胞因子含量、抗氧化酶活性、紧密连接和抗氧化相关基因表达.[结果]与对照组相比,姜百组肉鸡回肠绒毛高度(VH)有增加的趋势(P=0.063),绒毛高度/隐窝深度(V/C)值显著提高(P<0.05);姜百组肉鸡空肠和回肠黏膜中分泌性免疫球蛋白A(sIgA)含量显著提高(P<0.05),空肠黏膜中白介素6(IL-6)和干扰素γ(IFN-γ)含量以及回肠黏膜中IL-6和白介素1β(IL-1β)含量显著降低(P<0.05);姜百组肉鸡空肠和回肠黏膜中总抗氧化能力(T-AOC)和谷胱甘肽过氧化物酶(GSH-Px)活性显著升高(P<0.05);姜百组肉鸡空肠黏膜中核因子E2 相关因子 2(Nrf2)、血红素加氧酶 1(HO-1)、谷胱甘肽过氧化物酶(GPX4)和回肠黏膜中Nrf2、超氧化物歧化酶 1(SOD1)、GPX4 的mRNA相对表达量显著升高(P<0.05),空肠和回肠黏膜中的Occludin mRNA相对表达量显著增加(P<0.05).[结论]日粮添加姜酚和百里香酚组合可以提高肉鸡的抗氧化能力和免疫功能,并通过改善肠道形态和肠道屏障促进肠道健康. |
| Abstract_FL | [Objectives]The study investigated the effects of dietary supplementation with gingerol,thymol and their combination on small intestinal morphology,immune function and intestinal barrier of white feather broilers.[Methods]A total of 200 1-day-old broilers were randomly divided into four groups with 5 replicates per group and 10 chickens per replicate as followings:the control group(Con group,basal diet),the gingerol group(Gin group,basal diet+60 mg·kg-1 gingerol),the thymol group(Thy group,basal diet+30 mg·kg-1 thymol)and the gingerol+thymol group(Gin+Thy group,basal diet+30 mg·kg-1 gingerol+15 mg·kg-1 thymol).On day 42 of the experimental period,the jejunum and ileum of broilers were collected to make sections and observed,and the mucosa of the jejunum and ileum were taken to determine the immunoglobulin content,cytokine content,antioxidant enzyme activities,tight junctions and antioxidant-related gene expression.[Results]The ileal villus height(VH)trended to increase(P=0.063)and the ratio of villus height/crypt depth(V/C)significantly increased(P<0.05)in Gin+Thy group compared with those in Con group.The secretory immunoglobulin A(sIgA)content in jejunal and ileal mucosa significantly increased(P<0.05),while the interleukin-6(IL-6)and interferon-γ(IFN-γ)content in jejunal mucosa,and the IL-6 and interleukin-1β(IL-1β)content in ileal mucosa significantly decreased(P<0.05)in Gin+Thy group compared with those in Con group.Total antioxidant capacity(T-AOC)and glutathione peroxidase(GSH-Px)activities in jejunal and ileal mucosa in Gin+Thy group significantly increased compared with Con group(P<0.05).The Gin+Thy group had a higher mRNA relative expression of nuclear factor E2-related factor 2(Nrf2),heme oxygenase 1(HO-1),glutathione peroxidase(GPX4)in jejunal mucosa,and a higher mRNA relative expression of Nrf2,superoxide dismutase 1(SOD1)and GPX4 in ileal mucosa than those in Con group(P<0.05).The mRNA relative expression level of Occludin in jejunal and ileal mucosa significantly increased in Gin+Thy group compared with Con group(P<0.05).[Conclusions]Dietary supplementation with the gingerol and thymol combination improved the antioxidant capacity and immune function,and enhanced intestinal health by improving intestinal morphology and intestinal barrier of broilers. |
| Author | 陈露 赵文轩 汪晶 吴建民 朱伟云 尹莉丽 |
| AuthorAffiliation | 南京农业大学动物科技学院/国家动物消化道营养国际联合研究中心,江苏 南京 210095 |
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| Author_FL | ZHAO Wenxuan ZHU Weiyun YIN Lili WU Jianmin CHEN Lu WANG Jing |
| Author_FL_xml | – sequence: 1 fullname: YIN Lili – sequence: 2 fullname: WU Jianmin – sequence: 3 fullname: CHEN Lu – sequence: 4 fullname: ZHAO Wenxuan – sequence: 5 fullname: WANG Jing – sequence: 6 fullname: ZHU Weiyun |
| Author_xml | – sequence: 1 fullname: 尹莉丽 – sequence: 2 fullname: 吴建民 – sequence: 3 fullname: 陈露 – sequence: 4 fullname: 赵文轩 – sequence: 5 fullname: 汪晶 – sequence: 6 fullname: 朱伟云 |
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| DOI | 10.7685/jnau.202209017 |
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| DocumentTitle_FL | Effect of gingerol and thymol on the small intestinal morphology and barrier function of white feather broilers |
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| Keywords | 肠道屏障 thymol gingerol 肠道形态 intestinal morphology 姜酚 intestinal barrier broiler 肉鸡 百里香酚 |
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| Publisher | 南京农业大学动物科技学院/国家动物消化道营养国际联合研究中心,江苏 南京 210095 |
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| Snippet | S831.5; [目的]本试验旨在研究日粮添加姜酚、百里香酚及其组合对白羽肉鸡小肠形态、免疫功能及肠道屏障的影响.[方法]将200只1日龄AA白羽肉鸡随机分为4组,每组5个重复,每个重复10只,试验期为42 d.4个处理组如下:对照组(Con组,基础日粮)、姜酚组(Gin组,基础日粮+60... |
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| Title | 姜酚和百里香酚对白羽肉鸡小肠形态结构和屏障功能的影响 |
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