具核梭杆菌促进结直肠癌发病相关机制的研究进展

R735.3; 具核梭杆菌(fusobacterium nucleatum,Fn)与结直肠癌(colorectal cancer,CRC)发生有关.有研究发现人类CRC中有过量的Fn,并阐明了Fn在体外和小鼠模型中参与CRC发生可能的机制.Fn参与CRC癌变的机制主要包括:通过增加髓系来源的抑制细胞和减少自然杀伤细胞等发挥的免疫调节;由FadA、Fap2和脂多糖介导的毒力作用;促进肿瘤相关microRNA(如miR-21)表达;代谢作用.本文就Fn在CRC中的作用机制作一综述....

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Published in中国临床医学 Vol. 27; no. 1; pp. 127 - 131
Main Authors 吕振涛, 钟芸诗, 陈涛, 周平红
Format Journal Article
LanguageChinese
Published 复旦大学附属中山医院内镜中心,上海,200032 01.02.2020
Subjects
具核梭杆菌
机制
结直肠癌
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ISSN1008-6358
DOI10.12025/j.issn.1008-6358.2020.20190397

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Abstract R735.3; 具核梭杆菌(fusobacterium nucleatum,Fn)与结直肠癌(colorectal cancer,CRC)发生有关.有研究发现人类CRC中有过量的Fn,并阐明了Fn在体外和小鼠模型中参与CRC发生可能的机制.Fn参与CRC癌变的机制主要包括:通过增加髓系来源的抑制细胞和减少自然杀伤细胞等发挥的免疫调节;由FadA、Fap2和脂多糖介导的毒力作用;促进肿瘤相关microRNA(如miR-21)表达;代谢作用.本文就Fn在CRC中的作用机制作一综述.
AbstractList R735.3; 具核梭杆菌(fusobacterium nucleatum,Fn)与结直肠癌(colorectal cancer,CRC)发生有关.有研究发现人类CRC中有过量的Fn,并阐明了Fn在体外和小鼠模型中参与CRC发生可能的机制.Fn参与CRC癌变的机制主要包括:通过增加髓系来源的抑制细胞和减少自然杀伤细胞等发挥的免疫调节;由FadA、Fap2和脂多糖介导的毒力作用;促进肿瘤相关microRNA(如miR-21)表达;代谢作用.本文就Fn在CRC中的作用机制作一综述.
Author 钟芸诗
陈涛
吕振涛
周平红
AuthorAffiliation 复旦大学附属中山医院内镜中心,上海,200032
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Lü Zhen-tao
ZHONG Yun-shi
ZHOU Ping-hong
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Title 具核梭杆菌促进结直肠癌发病相关机制的研究进展
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