高三酰甘油血症-腰围表型与2型糖尿病发病风险:一项前瞻性队列研究
R587.1; 背景 高三酰甘油血症-腰围表型是2型糖尿病(T2DM)的风险因素,不同性别、不同地区、不同年龄段及超重/肥胖人群中T2DM发病风险可能不同.目的 探讨不同性别、不同地区、不同年龄段及超重/肥胖人群高三酰甘油血症-腰围表型与T2DM发病风险的关系,为糖尿病防控提供科学依据.方法 本研究为前瞻性队列研究,2010年采取分层整群随机抽样方法,以贵州省12个县(市、区)18岁及以上9280名常住居民为队列人群进行基线调查.于2016—2020年进行随访,共随访到8163人,剔除基线时糖尿病患者、相关指标信息缺失者、失访和死亡的对象,最终纳入6743名调查对象.根据基线腰围(WC)和血清...
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| Published in | 中国全科医学 Vol. 28; no. 6; pp. 681 - 687 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
550001 贵州省贵阳市,贵州省疾病预防控制中心慢性病防治研究所慢病防治科
20.02.2025
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1007-9572 |
| DOI | 10.12114/j.issn.1007-9572.2024.0189 |
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| Abstract | R587.1; 背景 高三酰甘油血症-腰围表型是2型糖尿病(T2DM)的风险因素,不同性别、不同地区、不同年龄段及超重/肥胖人群中T2DM发病风险可能不同.目的 探讨不同性别、不同地区、不同年龄段及超重/肥胖人群高三酰甘油血症-腰围表型与T2DM发病风险的关系,为糖尿病防控提供科学依据.方法 本研究为前瞻性队列研究,2010年采取分层整群随机抽样方法,以贵州省12个县(市、区)18岁及以上9280名常住居民为队列人群进行基线调查.于2016—2020年进行随访,共随访到8163人,剔除基线时糖尿病患者、相关指标信息缺失者、失访和死亡的对象,最终纳入6743名调查对象.根据基线腰围(WC)和血清三酰甘油(TG)水平将调查对象分为4组,正常腰围和正常血清三酰甘油(NWNT)组:男性腰围<90 cm或女性腰围<85 cm、血清三酰甘油<1.7 mmol/L;正常腰围和高血清三酰甘油(NWHT)组:男性腰围<90 cm或女性腰围<85 cm、血清三酰甘油≥1.7 mmol/L;腰围增大和正常血清三酰甘油(EWNT)组:男性腰围≥90 cm或女性腰围≥85 cm、血清三酰甘油<1.7 mmol/L;腰围增大和高血清三酰甘油(EWHT)组:男性腰围≥90 cm或女性腰围≥85 cm、血清三酰甘油≥1.7 mmol/L.采用Cox比例风险回归模型分析高三酰甘油血症-腰围表型分组与新发T2DM之间的关系.结果 中位随访时间6.58年,6743名调查对象中新发T2DM 706例,发病率为10.47％.在调整了相关的混杂因素后,Cox比例风险回归分析显示,EWHT组T2DM发病风险是NWNT组的1.486倍(HR=1.486,95％CI=1.185～1.865,P=0.001).亚组多因素Cox比例风险回归分析显示,在男性、农村、年龄<45岁、超重/肥胖人群中,EWHT组T2DM发病风险分别是NWNT组的1.792倍(HR=1.792,95％CI=1.297～2.476,P<0.001)、1.483倍(HR=1.483,95％CI=1.115～1.971,P=0.007)、1.540倍(HR=1.540,95％CI=1.083～2.190,P=0.016)、1.614倍(HR=1.614,95％CI=1.123～2.321,P=0.010).结论 对大样本人群进行中位随访6.58年后,高三酰甘油血症-腰围表型是贵州省T2DM的发病风 |
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| AbstractList | R587.1; 背景 高三酰甘油血症-腰围表型是2型糖尿病(T2DM)的风险因素,不同性别、不同地区、不同年龄段及超重/肥胖人群中T2DM发病风险可能不同.目的 探讨不同性别、不同地区、不同年龄段及超重/肥胖人群高三酰甘油血症-腰围表型与T2DM发病风险的关系,为糖尿病防控提供科学依据.方法 本研究为前瞻性队列研究,2010年采取分层整群随机抽样方法,以贵州省12个县(市、区)18岁及以上9280名常住居民为队列人群进行基线调查.于2016—2020年进行随访,共随访到8163人,剔除基线时糖尿病患者、相关指标信息缺失者、失访和死亡的对象,最终纳入6743名调查对象.根据基线腰围(WC)和血清三酰甘油(TG)水平将调查对象分为4组,正常腰围和正常血清三酰甘油(NWNT)组:男性腰围<90 cm或女性腰围<85 cm、血清三酰甘油<1.7 mmol/L;正常腰围和高血清三酰甘油(NWHT)组:男性腰围<90 cm或女性腰围<85 cm、血清三酰甘油≥1.7 mmol/L;腰围增大和正常血清三酰甘油(EWNT)组:男性腰围≥90 cm或女性腰围≥85 cm、血清三酰甘油<1.7 mmol/L;腰围增大和高血清三酰甘油(EWHT)组:男性腰围≥90 cm或女性腰围≥85 cm、血清三酰甘油≥1.7 mmol/L.采用Cox比例风险回归模型分析高三酰甘油血症-腰围表型分组与新发T2DM之间的关系.结果 中位随访时间6.58年,6743名调查对象中新发T2DM 706例,发病率为10.47％.在调整了相关的混杂因素后,Cox比例风险回归分析显示,EWHT组T2DM发病风险是NWNT组的1.486倍(HR=1.486,95％CI=1.185～1.865,P=0.001).亚组多因素Cox比例风险回归分析显示,在男性、农村、年龄<45岁、超重/肥胖人群中,EWHT组T2DM发病风险分别是NWNT组的1.792倍(HR=1.792,95％CI=1.297～2.476,P<0.001)、1.483倍(HR=1.483,95％CI=1.115～1.971,P=0.007)、1.540倍(HR=1.540,95％CI=1.083～2.190,P=0.016)、1.614倍(HR=1.614,95％CI=1.123～2.321,P=0.010).结论 对大样本人群进行中位随访6.58年后,高三酰甘油血症-腰围表型是贵州省T2DM的发病风 |
| Abstract_FL | Background Hypertriglyceridemic-waist phenotype is a risk factor for type 2 diabetes mellitus(T2DM). The risk of T2DM may vary in different genders,regions,age groups,and overweight/obese people. Objective To explore the risk of T2DM by hypertriglyceridemic-waist phenotype in different genders,regions,ages,and overweight/obese people,and to provide a scientific basis for the prevention and control of T2DM. Methods This was a prospective cohort study involving 9280 permanent residents over 18 years in 12 districts(counties)of Guizhou province in 2010 selected by multi-stage stratified cluster random sampling. From 2016 to 2020,8163 residents were followed up,and finally 6743 eligible participants were enrolled after excluding those with baseline T2DM,lacking sufficient clinical data,lost to follow-up and deaths. Participants were assigned into 4 groups based on their baseline waist circumference(WC)and serum triacylglycerol(TG)levels:Normal WC and TG group(NWNT,WC<90 cm in men and WC<85 cm in women,TG<1.7 mmol/L),normal WC and high TG group (NWHT,WC<90 cm in men and WC<85 cm in women,TG ≥ 1.7 mmol/L),large WC and normal TG group(EWNT,WC≥90 cm in men or WC≥85 cm in women,TG<1.7 mmol/L)and large WC and high TG group(EWHT,WC≥90 cm in men or WC ≥ 85 cm in women,TG ≥ 1.7 mmol/L). A Cox proportional hazards regression model was used to analyze the correlation between hypertriglyceridemic-waist phenotype grouping and new-onset T2DM. Results The median follow-up period was 6.58 years. Among 6743 participants,new-onset T2DM was observed in 706(10.47％)individuals. After adjusting confounding factors,the Cox proportional hazards regression analysis showed that the risk of T2DM was 1.486 times in the EWHT group than the NWNT group(HR=1.486,95％CI=1.185-1.865,P=0.001). Multivariate Cox proportional hazards regression analysis showed that in the subgroups of male gender,rural region,aged<45 years,and overweight/obese,the risk of T2DM in the EWHT group was 1.792(HR=1.792,95％CI=1.297-2.476,P<0.001),1.483(HR=1.483,95％CI=1.115-1.971,P=0.007),1.540(HR=1.540,95％CI=1.083-2.190,P=0.016),and 1.614(HR=1.614,95％CI=1.123-2.321,P=0.010)times higher than the NWNT group,respectively. Conclusion After a median follow-up time of 6.58 years in a large cohort,the hypertriglyceridemic-waist phenotype is the risk of T2DM in Guizhou Province,which is more significant in males,rural areas,aged<45 years,and overweight/obese people. Therefore,health education should be strengthened for high-risk populations. Weight control through reasonable diet and appropriate exercise,and reducing serum triacylglycerol levels are necessary and effective methods to prevent the incidence of T2DM. |
| Author | 赵否曦 杜瑀 张骥 刘涛 汪姜涛 朱玲 吴延莉 |
| AuthorAffiliation | 550001 贵州省贵阳市,贵州省疾病预防控制中心慢性病防治研究所慢病防治科 |
| AuthorAffiliation_xml | – name: 550001 贵州省贵阳市,贵州省疾病预防控制中心慢性病防治研究所慢病防治科 |
| Author_FL | ZHU Ling WANG Jiangtao ZHANG Ji LIU Tao WU Yanli ZHAO Fouxi DU Yu |
| Author_FL_xml | – sequence: 1 fullname: ZHU Ling – sequence: 2 fullname: ZHAO Fouxi – sequence: 3 fullname: WANG Jiangtao – sequence: 4 fullname: DU Yu – sequence: 5 fullname: WU Yanli – sequence: 6 fullname: ZHANG Ji – sequence: 7 fullname: LIU Tao |
| Author_xml | – sequence: 1 fullname: 朱玲 – sequence: 2 fullname: 赵否曦 – sequence: 3 fullname: 汪姜涛 – sequence: 4 fullname: 杜瑀 – sequence: 5 fullname: 吴延莉 – sequence: 6 fullname: 张骥 – sequence: 7 fullname: 刘涛 |
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| Keywords | Diabetes mellitus,type 2 Waist circumference Risk of onset 前瞻性研究 腰围 糖尿病,2型 Cohort studies 发病风险 队列研究 Prospective studies 三酰基甘油类 Triacylglycerols |
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| Publisher | 550001 贵州省贵阳市,贵州省疾病预防控制中心慢性病防治研究所慢病防治科 |
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| Snippet | R587.1; 背景 高三酰甘油血症-腰围表型是2型糖尿病(T2DM)的风险因素,不同性别、不同地区、不同年龄段及超重/肥胖人群中T2DM发病风险可能不同.目的 探讨不同性别、不同地区、不同年龄段及超重/肥胖人群高三酰甘油血症-腰围表型与T2DM发病风险的关系,为糖尿病防控提供科学依据.方法... |
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| Title | 高三酰甘油血症-腰围表型与2型糖尿病发病风险:一项前瞻性队列研究 |
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