第3代促甲状腺素受体抗体测定法(Elecsys)对甲状腺毒血症的鉴别诊断价值

R581; 目的:探讨第3代促甲状腺素受体抗体(TRAb)检测方法——电化学发光法(Elecsys)对甲状腺毒血症病因鉴别的诊断价值.方法:回顾性选取2016年1月至2018年5月复旦大学附属华山医院收治的未经治疗的甲状腺毒血症患者154例,测定其甲状腺功能、TRAb、甲状腺摄碘率和甲状腺上动脉收缩期峰值流速(peak systolic velocity of superior thyroid artery,STA-PSV).采用ROC曲线比较第3代TRAb及STA-PSV对Graves病(Graves'disease,GD)和破坏性甲状腺炎(destructive thyroidi...

Full description

Saved in:
Bibliographic Details
Published in中国临床医学 Vol. 28; no. 1; pp. 80 - 84
Main Authors 陈立立, 俞一飞, 曾芳芳, 赵晓龙, 李益明, 刘红
Format Journal Article
LanguageChinese
Published 复旦大学附属华山医院内分泌科,上海 200040 01.02.2021
Subjects
第3代TRAb检测
鉴别诊断
甲状腺毒血症
电化学发光法
Online AccessGet full text

Cover

Abstract R581; 目的:探讨第3代促甲状腺素受体抗体(TRAb)检测方法——电化学发光法(Elecsys)对甲状腺毒血症病因鉴别的诊断价值.方法:回顾性选取2016年1月至2018年5月复旦大学附属华山医院收治的未经治疗的甲状腺毒血症患者154例,测定其甲状腺功能、TRAb、甲状腺摄碘率和甲状腺上动脉收缩期峰值流速(peak systolic velocity of superior thyroid artery,STA-PSV).采用ROC曲线比较第3代TRAb及STA-PSV对Graves病(Graves'disease,GD)和破坏性甲状腺炎(destructive thyroiditis,DT)的鉴别诊断价值.结果:154例甲状腺毒血症患者中,女性111例(72.0％),平均年龄38.42岁,GD 117例(76.0％).TRAb的AUC为0.984(95％CI 0.967～1.000),优于STA-PSV(AUC 0.903,95％CI 0.839～0.967).TRAb的最佳切割点为1.7 U/L,区分GD和DT的灵敏度和特异度为94.8％ 和94.3％.TRAb切割点为3.6 U/L时,其鉴别GD/DT的特异度和阳性预测值均为100％.结论:第3代TRAb检测(Elecsys)对甲状腺毒症的病因鉴别具有较高的灵敏度和特异度.
AbstractList R581; 目的:探讨第3代促甲状腺素受体抗体(TRAb)检测方法——电化学发光法(Elecsys)对甲状腺毒血症病因鉴别的诊断价值.方法:回顾性选取2016年1月至2018年5月复旦大学附属华山医院收治的未经治疗的甲状腺毒血症患者154例,测定其甲状腺功能、TRAb、甲状腺摄碘率和甲状腺上动脉收缩期峰值流速(peak systolic velocity of superior thyroid artery,STA-PSV).采用ROC曲线比较第3代TRAb及STA-PSV对Graves病(Graves'disease,GD)和破坏性甲状腺炎(destructive thyroiditis,DT)的鉴别诊断价值.结果:154例甲状腺毒血症患者中,女性111例(72.0％),平均年龄38.42岁,GD 117例(76.0％).TRAb的AUC为0.984(95％CI 0.967～1.000),优于STA-PSV(AUC 0.903,95％CI 0.839～0.967).TRAb的最佳切割点为1.7 U/L,区分GD和DT的灵敏度和特异度为94.8％ 和94.3％.TRAb切割点为3.6 U/L时,其鉴别GD/DT的特异度和阳性预测值均为100％.结论:第3代TRAb检测(Elecsys)对甲状腺毒症的病因鉴别具有较高的灵敏度和特异度.
Author 李益明
刘红
俞一飞
陈立立
赵晓龙
曾芳芳
AuthorAffiliation 复旦大学附属华山医院内分泌科,上海 200040
AuthorAffiliation_xml – name: 复旦大学附属华山医院内分泌科,上海 200040
Author_FL ZENG Fang-fang
LIU Hong
CHEN Li-li
YU Yi-fei
LI Yi-ming
ZHAO Xiao-long
Author_FL_xml – sequence: 1
  fullname: CHEN Li-li
– sequence: 2
  fullname: YU Yi-fei
– sequence: 3
  fullname: ZENG Fang-fang
– sequence: 4
  fullname: ZHAO Xiao-long
– sequence: 5
  fullname: LI Yi-ming
– sequence: 6
  fullname: LIU Hong
Author_xml – sequence: 1
  fullname: 陈立立
– sequence: 2
  fullname: 俞一飞
– sequence: 3
  fullname: 曾芳芳
– sequence: 4
  fullname: 赵晓龙
– sequence: 5
  fullname: 李益明
– sequence: 6
  fullname: 刘红
BookMark eNo9kElLA0EQhfsQwRjzO6KHGbu6e7ajhLhAwIteDT1bSBgmYCMaTwEVTTwIboGcFI9GBzQqGsU_M0v8F05UcvkK3iuqeG8GZfyG7yBUACwDwURZqMs1IXwZMNYllSq6nKowBgZdgwzKTpxplBeiZmIMWMGU4CzaTPp9Gg5vw6_95OIx6byMDt-TwXV02g0_z-POL59Poode_HQ5V_IcSzTFfBS8TZbj4Gx000q6R0nv4Ls9iI7vRkEnvroPh69R62MWTbncE07-f-bQxlJpvbgildeWV4uLZUlAmkBSHRuoRg1iE9CZwXXbMTGltqrojDEOFgNOgWlMsYlrGmARy8LEdk3GieoYLs2hwt_dHe673K9W6o3tLT_9WNmrelZzd9xIGhoU-gMyzni5
ClassificationCodes R581
ContentType Journal Article
Copyright Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 2B.
4A8
92I
93N
PSX
TCJ
DOI 10.12025/j.issn.1008-6358.2021.20201871
DatabaseName Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
DocumentTitle_FL Clinical value of 3rd generation assay of thyroid stimulating hormone receptor antibody ( Elecsys ) for differential diagnosis of thyrotoxicosis
EndPage 84
ExternalDocumentID zglcyx202101015
GrantInformation_xml – fundername: 上海市卫生和计划生育委员会研究课题
  funderid: (20154Y0013)
GroupedDBID 2B.
4A8
92I
93N
ALMA_UNASSIGNED_HOLDINGS
CDYEO
PSX
TCJ
ID FETCH-LOGICAL-s1025-6ed137392d21849a8deb033d658444a1c41a314745d2fb91c2cc02dfb4a26e9f3
ISSN 1008-6358
IngestDate Thu May 29 04:08:22 EDT 2025
IsPeerReviewed false
IsScholarly true
Issue 1
Keywords 第3代TRAb检测
鉴别诊断
甲状腺毒血症
电化学发光法
Language Chinese
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-s1025-6ed137392d21849a8deb033d658444a1c41a314745d2fb91c2cc02dfb4a26e9f3
PageCount 5
ParticipantIDs wanfang_journals_zglcyx202101015
PublicationCentury 2000
PublicationDate 2021-02-01
PublicationDateYYYYMMDD 2021-02-01
PublicationDate_xml – month: 02
  year: 2021
  text: 2021-02-01
  day: 01
PublicationDecade 2020
PublicationTitle 中国临床医学
PublicationTitle_FL Chinese Journal of Clinical Medicine
PublicationYear 2021
Publisher 复旦大学附属华山医院内分泌科,上海 200040
Publisher_xml – name: 复旦大学附属华山医院内分泌科,上海 200040
SSID ssib001050320
ssib006562945
ssib036441625
ssib001103563
ssib002262996
ssib008144075
ssib051368386
Score 2.2271469
Snippet R581;...
SourceID wanfang
SourceType Aggregation Database
StartPage 80
Title 第3代促甲状腺素受体抗体测定法(Elecsys)对甲状腺毒血症的鉴别诊断价值
URI https://d.wanfangdata.com.cn/periodical/zglcyx202101015
Volume 28
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9VAFI61grgRRcU3XTioi1uTzCMzy8m9uRRBVy10ZcmzIuUKtgXtqqCi1oXgq9CV4tJqQauiVfwz91H_hedMkptLW-oDwjCcfHPmPJLMOZNJxrLOxTSyhYqSWmbLpMbiKKpFIQRyiRJSSBYyHmKieOWqGJtglyf55NDwnoFVS_Nz0Wi8sON3Jf_jVaCBX_Er2X_wbJ8pEKAO_oUSPAzlX_mYBB7RdTgoCRjxfaLzSpNIiucU1F2sSE18QQJJJCe-RorPiLZJwIlsEuWZVg2ioJVA8BaKDzAfwTogShsKJYpDcBrMpPEsXgvKnG4SX-3asUCMcpGiHVxlgWCAeaaiiWQkUEQqlA-FA5hvwE1kBc0VcGgU2vqewdik2J77RmkVOCsNjBPloxo5JecJYiAraFhHJih2g-j-BCX2rxT2jMb1jeJFpYIYG6ug4ItqKLS9CiqIMF0HRneN9iorFUSiYeFArDKmVtgi38qpnIpxnXL1dnHzGIkhA2iYdiCaKCja6ytTKpEr7BhROTaRQUGBozKBAWvXUAS6Kjc91HNXAwxtAB6Cca9eaq2LS8P38L-Udv4_rGKAw-UuEGTKwRHQldvu9Hw4yzfZKgMjtuOQC4bgZsxF_qN9_qNoICxw10enijb6a0AXpmfiO7cRhb855HutfS5keu7ArEg-Y8FtOpDRQLRKuRiMQAUEVFVEDemJqwZelEtcvFBFyBTDf1ENYdyhQlKzH2xf8v3W-VKvS7trZT70a2Vha3ogJh0_ZB0skskRnT8ZDltDC9ePWNd6q6u0vfGm_fNu7_mH3tLnzfvfeuuvOk-W2z-edZdM-elx5_1K9-OLC8X9e7Gz9rUP7q493Xy92Ft-0Fu59-vReufh2821pe7Ld-2NL53F70etiWYwXh-rFbuo1GYd3KtapIlDPUiDEpzNUaFMUrADTTD1YCx0YuaE1GEe44mbRcqJ3Ti23SSLWOiKVGX0mDXcutlKj1sj1AvdJMpoFqYZ49xTSQqP8zB20kSlyg5PWCOFPaaKp-Ts1BY3n_wz5JR1oLq5TlvDc7fm0zMQ-c9FZ8218RsWIMiW
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E7%AC%AC3%E4%BB%A3%E4%BF%83%E7%94%B2%E7%8A%B6%E8%85%BA%E7%B4%A0%E5%8F%97%E4%BD%93%E6%8A%97%E4%BD%93%E6%B5%8B%E5%AE%9A%E6%B3%95%28Elecsys%29%E5%AF%B9%E7%94%B2%E7%8A%B6%E8%85%BA%E6%AF%92%E8%A1%80%E7%97%87%E7%9A%84%E9%89%B4%E5%88%AB%E8%AF%8A%E6%96%AD%E4%BB%B7%E5%80%BC&rft.jtitle=%E4%B8%AD%E5%9B%BD%E4%B8%B4%E5%BA%8A%E5%8C%BB%E5%AD%A6&rft.au=%E9%99%88%E7%AB%8B%E7%AB%8B&rft.au=%E4%BF%9E%E4%B8%80%E9%A3%9E&rft.au=%E6%9B%BE%E8%8A%B3%E8%8A%B3&rft.au=%E8%B5%B5%E6%99%93%E9%BE%99&rft.date=2021-02-01&rft.pub=%E5%A4%8D%E6%97%A6%E5%A4%A7%E5%AD%A6%E9%99%84%E5%B1%9E%E5%8D%8E%E5%B1%B1%E5%8C%BB%E9%99%A2%E5%86%85%E5%88%86%E6%B3%8C%E7%A7%91%2C%E4%B8%8A%E6%B5%B7+200040&rft.issn=1008-6358&rft.volume=28&rft.issue=1&rft.spage=80&rft.epage=84&rft_id=info:doi/10.12025%2Fj.issn.1008-6358.2021.20201871&rft.externalDocID=zglcyx202101015
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzglcyx%2Fzglcyx.jpg