2型糖尿病患者血尿酸水平与视网膜血管直径的相关性研究
目的:探讨2型糖尿病（T2DM）患者血尿酸（UA）水平与视网膜血管直径的相关性。方法:收集2011年1月至2016年8月在空军军医大学第一附属医院内分泌科住院治疗的18~70岁的T2DM患者。记录患者的身高、体重、体重指数（BMI）、收缩压、舒张压、血UA、糖化血红蛋白（HbA 1c）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和估算的肾小球滤过率（eGFR）等指标。采用全自动计算机图像分析软件进行全眼底范围视网膜血管参数测量，包括中央小动脉直径（aCtr）、中间小动脉直径（aMdl）、外周小动脉直径（aPeri）、中央小静脉直径（v...
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| Published in | 中华糖尿病杂志 Vol. 13; no. 8; pp. 803 - 808 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
空军军医大学基础医学院三大队，西安 710032%空军军医大学第二附属医院内分泌科，西安 710038%空军军医大学第一附属医院内分泌科，西安 710032
27.08.2021
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1674-5809 |
| DOI | 10.3760/cma.j.cn115791-20210121-00032 |
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| Abstract | 目的:探讨2型糖尿病（T2DM）患者血尿酸（UA）水平与视网膜血管直径的相关性。方法:收集2011年1月至2016年8月在空军军医大学第一附属医院内分泌科住院治疗的18~70岁的T2DM患者。记录患者的身高、体重、体重指数（BMI）、收缩压、舒张压、血UA、糖化血红蛋白（HbA
1c）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和估算的肾小球滤过率（eGFR）等指标。采用全自动计算机图像分析软件进行全眼底范围视网膜血管参数测量，包括中央小动脉直径（aCtr）、中间小动脉直径（aMdl）、外周小动脉直径（aPeri）、中央小静脉直径（vCtr）、中间小静脉直径（vMdl）和外周小静脉直径（vPeri）。两组间比较采用Mann-Whitney
U检验或
t检验，多组间比较采用Kruskal-Wallis
H检验，采用有序logistic回归分析评价不同性别中血UA水平与视网膜血管直径的相关性。
结果:共纳入1 660例T2DM患者，其中男性1 171例，女性489例。不同性别患者的血UA、aCtr、aMdl、aPeri、vCtr、vMdl、vPeri水平差异均有统计学意义（
P<0.05）。有序logistic回归分析结果显示，在男性中，血UA水平升高是aCtr和vPeri增宽的危险因素（比值比分别为1.461和1.411，
P均<0.05）；在女性中，血UA水平升高是aPeri变窄的危险因素，是vPeri增宽的危险因素（比值比分别为2.161和1.592，
P均<0.05）。
结论:T2DM患者的血UA水平与视网膜血管的直径变化密切相关。在男性中，血UA水平升高是aCtr和vPeri增宽的独立危险因素；在女性中，血UA水平升高是aPeri变窄及vPeri增宽的独立危险因素。 |
|---|---|
| AbstractList | 目的:探讨2型糖尿病（T2DM）患者血尿酸（UA）水平与视网膜血管直径的相关性。方法:收集2011年1月至2016年8月在空军军医大学第一附属医院内分泌科住院治疗的18~70岁的T2DM患者。记录患者的身高、体重、体重指数（BMI）、收缩压、舒张压、血UA、糖化血红蛋白（HbA
1c）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和估算的肾小球滤过率（eGFR）等指标。采用全自动计算机图像分析软件进行全眼底范围视网膜血管参数测量，包括中央小动脉直径（aCtr）、中间小动脉直径（aMdl）、外周小动脉直径（aPeri）、中央小静脉直径（vCtr）、中间小静脉直径（vMdl）和外周小静脉直径（vPeri）。两组间比较采用Mann-Whitney
U检验或
t检验，多组间比较采用Kruskal-Wallis
H检验，采用有序logistic回归分析评价不同性别中血UA水平与视网膜血管直径的相关性。
结果:共纳入1 660例T2DM患者，其中男性1 171例，女性489例。不同性别患者的血UA、aCtr、aMdl、aPeri、vCtr、vMdl、vPeri水平差异均有统计学意义（
P<0.05）。有序logistic回归分析结果显示，在男性中，血UA水平升高是aCtr和vPeri增宽的危险因素（比值比分别为1.461和1.411，
P均<0.05）；在女性中，血UA水平升高是aPeri变窄的危险因素，是vPeri增宽的危险因素（比值比分别为2.161和1.592，
P均<0.05）。
结论:T2DM患者的血UA水平与视网膜血管的直径变化密切相关。在男性中，血UA水平升高是aCtr和vPeri增宽的独立危险因素；在女性中，血UA水平升高是aPeri变窄及vPeri增宽的独立危险因素。 |
| Abstract_FL | Objective:To analyze the relationship between serum uric acid (UA) and retinal vessel calibers in patients with type 2 diabetes mellitus (T2DM).Methods:T2DM patients aged between 18 and 70 years old who were hospitalized in the Department of Endocrinology of First Affiliated Hospital of Air Force Military Medical University from January 2011 to August 2016 were enrolled. Height, weight, body mass index (BMI), systolic blood pressure, diastolic blood pressure, serum UA, glycated hemoglobin A
1c (HbA
1c), total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C), and estimated glomerular filtration rate (eGFR) were recorded. The retinal vascular parameters in the whole fundus range were measured by automatic computer image analysis software, which were central arteriole caliber (aCtr), middle arteriole caliber (aMdl), peripheral arteriole caliber (aPeri), central arteriole caliber (vCtr), middle arteriole caliber (vMdl) and peripheral arteriole caliber (vPeri). Mann-Whitney
U test or
t test was used for comparison between two groups, Kruskal-Wallis
H test was used for comparisons among multiple groups, and ordered logistic regression analysis was used to evaluate the correlation between serum UA level and retinal vascular diameter in different genders.
Results:A total of 1 660 patients with T2DM were enrolled, including 1 171 men and 489 women. There were statistically significant differences in serum UA, aCtr, aMdl, aPeri, vCtr, vMdl and vPeri levels among different genders (
P<0.05). Ordered logistic regression analysis showed that elevated serum UA was a risk factor for widened aCtr and vPeri in males (odds ratios were 1.461 and 1.411, respectively, both
P<0.05). In women, elevated serum UA was a risk factor for aPeri narrowing and for vPeri widening (odds ratios of 2.161 and 1.592, respectively, both
P<0.05).
Conclusions:Serum uric acid level is closely associated with retinal vessel calibers in patients with T2DM. In men, elevated serum UA level was an independent risk factor for the widening of aCtr and vPeri, while in women, elevated serum uric acid level was an independent risk factor for the narrowing of aPeri and the widening of vPeri. |
| Author | 金鑫 张麦叶 孙飞 杨艾利 高彬 王琼 |
| AuthorAffiliation | 空军军医大学基础医学院三大队，西安 710032%空军军医大学第二附属医院内分泌科，西安 710038%空军军医大学第一附属医院内分泌科，西安 710032 |
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| Author_FL | Gao Bin Jin Xin Yang Aili Wang Qiong Zhang Maiye Sun Fei |
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| Issue | 8 |
| Keywords | 血尿酸 糖尿病，2型 视网膜血管 Retinal vascular Serum uric acid Diabetes mellites, type 2 直径 Caliber |
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| PublicationTitle | 中华糖尿病杂志 |
| PublicationTitle_FL | Chinese Journal of Diabetes Mellitus |
| PublicationYear | 2021 |
| Publisher | 空军军医大学基础医学院三大队，西安 710032%空军军医大学第二附属医院内分泌科，西安 710038%空军军医大学第一附属医院内分泌科，西安 710032 |
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| Title | 2型糖尿病患者血尿酸水平与视网膜血管直径的相关性研究 |
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