血糖监测新指标：唾液1，5-脱水葡萄糖醇正常参考范围的研究
目的:初步探索中国人群中唾液1，5-脱水葡萄糖醇（1，5-AG）的正常参考范围，为临床推广应用这一无创检测手段提供依据。方法:2018?年9?月至2019?年6?月于上海交通大学附属第六人民医院招募224?例正常糖代谢受试者（20~69?岁，男59?例、女165?例），通过1 min咀嚼40~50?次Salivette唾液采集管收集唾液，采用液相色谱质谱联用（LC-MS）检测唾液1，5-AG水平，采用酶法测定血清1，5-AG水平。组间比较采用独立样本 t检验、方差分析、Wilcoxon秩和检验及Kruskal-Wallis检验。采用Spearman相关分析及多元线性回归研究唾液1，5-AG与其...
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| Published in | 中华糖尿病杂志 Vol. 12; no. 7; pp. 480 - 485 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
上海交通大学附属第六人民医院内分泌代谢科 上海市糖尿病临床医学中心 200233%上海交通大学附属第六人民医院转化医学中心 200233
27.07.2020
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1674-5809 |
| DOI | 10.3760/cma.j.cn115791-20191030-00399 |
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| Abstract | 目的:初步探索中国人群中唾液1，5-脱水葡萄糖醇（1，5-AG）的正常参考范围，为临床推广应用这一无创检测手段提供依据。方法:2018?年9?月至2019?年6?月于上海交通大学附属第六人民医院招募224?例正常糖代谢受试者（20~69?岁，男59?例、女165?例），通过1 min咀嚼40~50?次Salivette唾液采集管收集唾液，采用液相色谱质谱联用（LC-MS）检测唾液1，5-AG水平，采用酶法测定血清1，5-AG水平。组间比较采用独立样本
t检验、方差分析、Wilcoxon秩和检验及Kruskal-Wallis检验。采用Spearman相关分析及多元线性回归研究唾液1，5-AG与其他指标的关系。
结果:（1）224?例正常人中唾液1，5-AG平均水平为0.53（0.35~0.77）mg/L，且无性别差异（
P=0.118）。（2）将研究对象按照年龄分为20~29?岁、30~49?岁、50~69?岁三个亚组，无论男性或女性，唾液1，5-AG水平在3?个年龄亚组间差异无统计学意义（均
P>0.05）。（3）根据体质指数（BMI）水平将研究对象分为18.5~20.9、21.0~22.9和23.0~24.9 kg/m
2三个亚组，无论男性或女性，唾液1，5-AG在3?个BMI亚组间差异均无统计学意义（均
P>0.05）。（4）唾液1，5-AG的正常参考范围（2.5%~97.5%）为0.09~1.63 mg/L，血清1, 5-AG是唾液1，5-AG的唯一独立影响因素（标准化
β=0.279，
t=3.636，
P<0.01）。
结论:基于LC-MS检测方法，唾液1，5-AG的正常参考范围为0.09~1.63 mg/L。唾液1，5-AG不受性别、年龄及BMI影响，临床应用无创便捷且较为稳定，可能成为糖尿病患者血糖监测的另一补充工具。 |
|---|---|
| AbstractList | 目的:初步探索中国人群中唾液1，5-脱水葡萄糖醇（1，5-AG）的正常参考范围，为临床推广应用这一无创检测手段提供依据。方法:2018?年9?月至2019?年6?月于上海交通大学附属第六人民医院招募224?例正常糖代谢受试者（20~69?岁，男59?例、女165?例），通过1 min咀嚼40~50?次Salivette唾液采集管收集唾液，采用液相色谱质谱联用（LC-MS）检测唾液1，5-AG水平，采用酶法测定血清1，5-AG水平。组间比较采用独立样本
t检验、方差分析、Wilcoxon秩和检验及Kruskal-Wallis检验。采用Spearman相关分析及多元线性回归研究唾液1，5-AG与其他指标的关系。
结果:（1）224?例正常人中唾液1，5-AG平均水平为0.53（0.35~0.77）mg/L，且无性别差异（
P=0.118）。（2）将研究对象按照年龄分为20~29?岁、30~49?岁、50~69?岁三个亚组，无论男性或女性，唾液1，5-AG水平在3?个年龄亚组间差异无统计学意义（均
P>0.05）。（3）根据体质指数（BMI）水平将研究对象分为18.5~20.9、21.0~22.9和23.0~24.9 kg/m
2三个亚组，无论男性或女性，唾液1，5-AG在3?个BMI亚组间差异均无统计学意义（均
P>0.05）。（4）唾液1，5-AG的正常参考范围（2.5%~97.5%）为0.09~1.63 mg/L，血清1, 5-AG是唾液1，5-AG的唯一独立影响因素（标准化
β=0.279，
t=3.636，
P<0.01）。
结论:基于LC-MS检测方法，唾液1，5-AG的正常参考范围为0.09~1.63 mg/L。唾液1，5-AG不受性别、年龄及BMI影响，临床应用无创便捷且较为稳定，可能成为糖尿病患者血糖监测的另一补充工具。 |
| Abstract_FL | Objective:To explore the normal reference interval of saliva 1, 5-anhydroglucitol (1, 5-AG) in Chinese population, and to give evidence for clinical application of the noninvasive examination method.Methods:A total of 224 subjects with normal glucose tolerance (aged 20-69, 59 male and 165 female) were enrolled in Shanghai Jiao Tong University Affiliated Sixth People′s Hospital from September 2018 to June 2019 and chewed the cottons in the Salivette tubes 40-50 times for 1 minute to collect saliva. Saliva 1, 5-AG levels were measured using liquid chromatography-mass spectrometry (LC-MS) and serum 1, 5-AG levels were measured with enzymatic method. The independent sample
t test, analysis of variance, Wilcoxon rank sum test and Kruskal-Wallis test were used for the inter-group comparison. Spearman correlation analysis and multiple linear regression were used to study the relationship between saliva 1, 5-AG and other indicators.
Results:(1) The average level of saliva 1, 5-AG in 224 normal subjects was 0.53 (0.35-0.77) mg/L, and there was no gender difference in saliva 1, 5-AG levels (
P=0.118). (2) According to age the subjects were divided into three subgroups: 20-29 years, 30-49 years and 50-69 years. There were no significant differences in saliva 1, 5-AG levels among three age subgroups in both male and female (all
P>0.05). (3) According to body mass index (BMI) the subjects were divided into three subgroups: 18.5-20.9 kg/m
2, 21.0-22.9 kg/m
2 and 23.0-24.9 kg/m
2. There were no significant differences in saliva 1, 5-AG levels among three BMI subgroups in both male and female (all
P>0.05). (4) The normal reference interval of saliva 1, 5-AG (the 2.5-97.5 percentiles) was 0.09-1.63 mg/L, serum 1, 5-AG was the only independent factor associated with saliva 1, 5-AG (standardized β=0.279,
t=3.636,
P<0.01).
Conclusion:Based on LC-MS determination method the normal reference interval of saliva 1, 5-AG was 0.09-1.63 mg/L. Saliva 1, 5-AG is not affected by gender, age and BMI and is noninvasive, convenient and robust for clinical application and may become another complementary tool for blood glucose monitoring in diabetes. |
| Author | 包玉倩 朱玮 马晓静 赵爱华 菅朝慧 陆蔚 周健 王煜非 |
| AuthorAffiliation | 上海交通大学附属第六人民医院内分泌代谢科 上海市糖尿病临床医学中心 200233%上海交通大学附属第六人民医院转化医学中心 200233 |
| AuthorAffiliation_xml | – name: 上海交通大学附属第六人民医院内分泌代谢科 上海市糖尿病临床医学中心 200233%上海交通大学附属第六人民医院转化医学中心 200233 |
| Author_FL | Zhou Jian Lu Wei Ma Xiaojing Jian Chaohui Zhu Wei Zhao Aihua Bao Yuqian Wang Yufei |
| Author_FL_xml | – sequence: 1 fullname: Jian Chaohui – sequence: 2 fullname: Zhao Aihua – sequence: 3 fullname: Ma Xiaojing – sequence: 4 fullname: Lu Wei – sequence: 5 fullname: Zhu Wei – sequence: 6 fullname: Wang Yufei – sequence: 7 fullname: Zhou Jian – sequence: 8 fullname: Bao Yuqian |
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| DocumentTitle_FL | Research on the normal reference interval of saliva 1, 5-anhydroglucitol: a new glucose monitoring indicator |
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| Keywords | Glucose monitoring 血糖监测 正常参考范围 Normal reference interval 液相色谱质谱联用 Liquid chromatography-mass spectrometry 唾液检测 Saliva determination 1，5-脱水葡萄糖醇 1, 5-Anhydroglucitol |
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| PublicationTitle | 中华糖尿病杂志 |
| PublicationTitle_FL | Chinese Journal of Diabetes Mellitus |
| PublicationYear | 2020 |
| Publisher | 上海交通大学附属第六人民医院内分泌代谢科 上海市糖尿病临床医学中心 200233%上海交通大学附属第六人民医院转化医学中心 200233 |
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| Snippet | 目的:初步探索中国人群中唾液1，5-脱水葡萄糖醇（1，5-AG）的正常参考范围，为临床推广应用这一无创检测手段提供依据。方法:2018?年9?月至2019?年6?月于上海交通大学附属第六人民医院招募224?例正常糖代谢受试者（20~69?岁，男59?例、女165?例），通过1... |
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| Title | 血糖监测新指标：唾液1，5-脱水葡萄糖醇正常参考范围的研究 |
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