陈旧骸骨DNA身份鉴定的法医学进展
R89%DF795.2%D919.2; 骨骼和牙齿是重要的生物样本,由于结构特殊,抗降解能力强,是自然条件下保留DNA理想的生物检材.在历史人物鉴定案例中,陈旧的骨骼和牙齿样本常常是唯一的生物检材,但其DNA呈微量、毁损和不同程度降解状态,需要经过特殊的实验处理以实现身份鉴定.本文综合近年来相关研究报道,从采集检材、DNA提取、DNA富集、检测分析方案等方面进行综述,以期促进陈旧骨骼和牙齿检测体系的进一步发展和完善....
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| Published in | 法医学杂志 Vol. 39; no. 5; pp. 478 - 486 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
军事医学研究院生物信息中心,北京 100850
2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1004-5619 |
| DOI | 10.12116/j.issn.1004-5619.2021.511209 |
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| Abstract | R89%DF795.2%D919.2; 骨骼和牙齿是重要的生物样本,由于结构特殊,抗降解能力强,是自然条件下保留DNA理想的生物检材.在历史人物鉴定案例中,陈旧的骨骼和牙齿样本常常是唯一的生物检材,但其DNA呈微量、毁损和不同程度降解状态,需要经过特殊的实验处理以实现身份鉴定.本文综合近年来相关研究报道,从采集检材、DNA提取、DNA富集、检测分析方案等方面进行综述,以期促进陈旧骨骼和牙齿检测体系的进一步发展和完善. |
|---|---|
| AbstractList | R89%DF795.2%D919.2; 骨骼和牙齿是重要的生物样本,由于结构特殊,抗降解能力强,是自然条件下保留DNA理想的生物检材.在历史人物鉴定案例中,陈旧的骨骼和牙齿样本常常是唯一的生物检材,但其DNA呈微量、毁损和不同程度降解状态,需要经过特殊的实验处理以实现身份鉴定.本文综合近年来相关研究报道,从采集检材、DNA提取、DNA富集、检测分析方案等方面进行综述,以期促进陈旧骨骼和牙齿检测体系的进一步发展和完善. |
| Author | 周喆 陈璐 王升启 |
| AuthorAffiliation | 军事医学研究院生物信息中心,北京 100850 |
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| Author_FL | WANG Sheng-qi ZHOU Zhe CHEN Lu |
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| DocumentTitle_FL | Process of Forensic Medicine in DNA Identification of Aged Human Remains |
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| Keywords | 降解 high throughput se-quencing 牙齿 高通量测序 degraded 身份鉴定 陈旧骸骨 法医遗传学 review forensic genetics individual identification 综述 aged skeleton tooth |
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| Title | 陈旧骸骨DNA身份鉴定的法医学进展 |
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