HPLC-Q-TOF MS法研究3种银杏双黄酮成分的质谱裂解途径
O657.63; 本研究采用高效液相色谱-串联四极杆飞行时间质谱(HPLC-Q-TOF MS)在负离子模式下分析3种银杏双黄酮(7-去甲基银杏双黄酮、金松双黄酮、异银杏双黄酮)的质谱裂解途径.结果 表明,3种化合物具有相似的裂解途径,均易丢失CH3OH和CO2,且该类成分在Ⅰ-C环和Ⅱ-C环发生多种Retro-Diels-Alder(RDA)裂解,可进一步失去取代基,得到相应的特征碎片离子.该结论可为银杏双黄酮类的结构鉴定提供依据....
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| Published in | 质谱学报 Vol. 41; no. 1; pp. 57 - 65 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
中国中医科学院西苑医院基础医学研究所,中药药理北京市重点实验室,北京100091%中国中医科学院西苑医院基础医学研究所,中药药理北京市重点实验室,北京100091
2020
北京中医药大学研究生院,北京100029 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1004-2997 |
| DOI | 10.7538/zpxb.2019.0011 |
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| Abstract | O657.63; 本研究采用高效液相色谱-串联四极杆飞行时间质谱(HPLC-Q-TOF MS)在负离子模式下分析3种银杏双黄酮(7-去甲基银杏双黄酮、金松双黄酮、异银杏双黄酮)的质谱裂解途径.结果 表明,3种化合物具有相似的裂解途径,均易丢失CH3OH和CO2,且该类成分在Ⅰ-C环和Ⅱ-C环发生多种Retro-Diels-Alder(RDA)裂解,可进一步失去取代基,得到相应的特征碎片离子.该结论可为银杏双黄酮类的结构鉴定提供依据. |
|---|---|
| AbstractList | O657.63; 本研究采用高效液相色谱-串联四极杆飞行时间质谱(HPLC-Q-TOF MS)在负离子模式下分析3种银杏双黄酮(7-去甲基银杏双黄酮、金松双黄酮、异银杏双黄酮)的质谱裂解途径.结果 表明,3种化合物具有相似的裂解途径,均易丢失CH3OH和CO2,且该类成分在Ⅰ-C环和Ⅱ-C环发生多种Retro-Diels-Alder(RDA)裂解,可进一步失去取代基,得到相应的特征碎片离子.该结论可为银杏双黄酮类的结构鉴定提供依据. |
| Author | 林力 孙明谦 张聪 刘建勋 尹春园 |
| AuthorAffiliation | 北京中医药大学研究生院,北京100029;中国中医科学院西苑医院基础医学研究所,中药药理北京市重点实验室,北京100091%中国中医科学院西苑医院基础医学研究所,中药药理北京市重点实验室,北京100091 |
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| Author_FL | YIN Chun-yuan LIN Li LIU Jian-xun SUN Ming-qian ZHANG Cong |
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| DocumentTitle_FL | Mass Spectrometric Fragmentation Pathways of Three Ginkgo Biloba Flavonoids Using HPLC-Q-TOF MS |
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| Keywords | 银杏双黄酮 裂解途径 RDA裂解 飞行时间质谱 |
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| Snippet | O657.63; 本研究采用高效液相色谱-串联四极杆飞行时间质谱(HPLC-Q-TOF MS)在负离子模式下分析3种银杏双黄酮(7-去甲基银杏双黄酮、金松双黄酮、异银杏双黄酮)的质谱裂解途径.结果... |
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| Title | HPLC-Q-TOF MS法研究3种银杏双黄酮成分的质谱裂解途径 |
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