人体泪液中尼古丁的Schirmer试纸采集及原位质谱检测

O657.63; 日常长时间暴露在烟草烟雾环境对人眼健康具有重要影响.本研究采用医用Schirmer试纸直接无创采集暴露在烟草烟雾环境下微量的人体泪液,通过施加电压与溶剂直接发生纸喷雾电离,并采用原位质谱检测.实验考察了尼古丁检测的灵敏度、精密度、回收率、定量检测线性范围等分析性能,以及不同暴露时间下泪液中尼古丁含量的变化.结果表明,Schirmer试纸喷雾电离质谱具有安全无创、操作简便、灵敏度高、特异性好、泪液消耗量低至1.0μL等优点,为人眼的环境暴露与健康分析提供了有效方法....

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Published in质谱学报 Vol. 42; no. 4; pp. 480 - 486
Main Authors 狄丹丹, 王昭涵, 胡斌
Format Journal Article
LanguageChinese
Published 暨南大学质谱仪器与大气环境研究所,广东 广州 510632%暨南大学药学院,广东 广州 510632 01.07.2021
Subjects
原位质谱
纸喷雾质谱
Schirmer试纸
泪液
尼古丁
Online AccessGet full text
ISSN1004-2997
DOI10.7538/zpxb.2021.0025

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Abstract O657.63; 日常长时间暴露在烟草烟雾环境对人眼健康具有重要影响.本研究采用医用Schirmer试纸直接无创采集暴露在烟草烟雾环境下微量的人体泪液,通过施加电压与溶剂直接发生纸喷雾电离,并采用原位质谱检测.实验考察了尼古丁检测的灵敏度、精密度、回收率、定量检测线性范围等分析性能,以及不同暴露时间下泪液中尼古丁含量的变化.结果表明,Schirmer试纸喷雾电离质谱具有安全无创、操作简便、灵敏度高、特异性好、泪液消耗量低至1.0μL等优点,为人眼的环境暴露与健康分析提供了有效方法.
AbstractList O657.63; 日常长时间暴露在烟草烟雾环境对人眼健康具有重要影响.本研究采用医用Schirmer试纸直接无创采集暴露在烟草烟雾环境下微量的人体泪液,通过施加电压与溶剂直接发生纸喷雾电离,并采用原位质谱检测.实验考察了尼古丁检测的灵敏度、精密度、回收率、定量检测线性范围等分析性能,以及不同暴露时间下泪液中尼古丁含量的变化.结果表明,Schirmer试纸喷雾电离质谱具有安全无创、操作简便、灵敏度高、特异性好、泪液消耗量低至1.0μL等优点,为人眼的环境暴露与健康分析提供了有效方法.
Author 狄丹丹
王昭涵
胡斌
AuthorAffiliation 暨南大学质谱仪器与大气环境研究所,广东 广州 510632%暨南大学药学院,广东 广州 510632
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HU Bin
DI Dan-dan
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Keywords 原位质谱
纸喷雾质谱
Schirmer试纸
泪液
尼古丁
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Title 人体泪液中尼古丁的Schirmer试纸采集及原位质谱检测
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