磁共振弥散加权成像预测食管癌放疗疗效的动物实验研究
目的 从动物实验层面探讨磁共振弥散加权成像(MR-DWI)技术预测食管癌放疗疗效的价值.方法 建立人食管癌Eca-109细胞裸鼠移植瘤模型.实验组(16只)给予单次15 Gy的6 MV-X线照射,对照组(24只)不接受任何治疗.两组于放疗前1d开始,隔日1次行MRI扫描,扫描序列包括T1WI、T2WI和DWI,观察1个月.根据两组移植瘤体积和ADC值的变化情况,选择7个关键时间点,观察实验组与对照组(每组6只)各时间点的细胞密度和组织坏死比例.结果 自放疗后第7天开始,实验组与对照组移植瘤体积差异有统计学意义.放疗后第7天移植瘤体积分别为(1.729±0.906)cm3和(2.671±0.91...
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| Published in | 中华肿瘤杂志 Vol. 41; no. 2; pp. 102 - 106 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
河北医科大学第四医院放疗科,石家庄,050011%河北医科大学第四医院CT与MRI科,石家庄,050011
01.02.2019
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| Abstract | 目的 从动物实验层面探讨磁共振弥散加权成像(MR-DWI)技术预测食管癌放疗疗效的价值.方法 建立人食管癌Eca-109细胞裸鼠移植瘤模型.实验组(16只)给予单次15 Gy的6 MV-X线照射,对照组(24只)不接受任何治疗.两组于放疗前1d开始,隔日1次行MRI扫描,扫描序列包括T1WI、T2WI和DWI,观察1个月.根据两组移植瘤体积和ADC值的变化情况,选择7个关键时间点,观察实验组与对照组(每组6只)各时间点的细胞密度和组织坏死比例.结果 自放疗后第7天开始,实验组与对照组移植瘤体积差异有统计学意义.放疗后第7天移植瘤体积分别为(1.729±0.906)cm3和(2.671±0.915)cm3,实验组小于对照组(P＜0.05).自放疗后第3天开始,实验组与对照组ADC值差异有统计学意义.放疗后第3天ADC值分别为(1.017±0.255)×10-6 mm2/s和(0.833±0.142)×10-6 mm2/s,实验组高于对照组(P＜0.05).自放疗后第3天开始,实验组与对照组移植瘤细胞密度和组织坏死比例差异有统计学意义.放疗后第3天,移植瘤细胞密度分别为(25.56±1.40)％和(33.48±4.18)％,实验组低于对照组(P＜0.05),组织坏死比例分别为(32.19±1.21)％和(29.16±2.16)％,实验组高于对照组(P＜0.05).ADC值与细胞密度呈负相关(r=-0.703,P＜0.001),与组织坏死比例呈正相关(r=0.658,P=0.003).结论 单次大剂量放射治疗可以抑制食管癌荷瘤裸鼠肿瘤生长,ADC值可以先于肿瘤形态学变化而发生改变.移植瘤细胞密度和组织坏死比例的变化与ADC值的变化基本吻合.MR-DWI技术具有早期预测食管癌放疗疗效的价值. |
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| AbstractList | 目的 从动物实验层面探讨磁共振弥散加权成像(MR-DWI)技术预测食管癌放疗疗效的价值.方法 建立人食管癌Eca-109细胞裸鼠移植瘤模型.实验组(16只)给予单次15 Gy的6 MV-X线照射,对照组(24只)不接受任何治疗.两组于放疗前1d开始,隔日1次行MRI扫描,扫描序列包括T1WI、T2WI和DWI,观察1个月.根据两组移植瘤体积和ADC值的变化情况,选择7个关键时间点,观察实验组与对照组(每组6只)各时间点的细胞密度和组织坏死比例.结果 自放疗后第7天开始,实验组与对照组移植瘤体积差异有统计学意义.放疗后第7天移植瘤体积分别为(1.729±0.906)cm3和(2.671±0.915)cm3,实验组小于对照组(P＜0.05).自放疗后第3天开始,实验组与对照组ADC值差异有统计学意义.放疗后第3天ADC值分别为(1.017±0.255)×10-6 mm2/s和(0.833±0.142)×10-6 mm2/s,实验组高于对照组(P＜0.05).自放疗后第3天开始,实验组与对照组移植瘤细胞密度和组织坏死比例差异有统计学意义.放疗后第3天,移植瘤细胞密度分别为(25.56±1.40)％和(33.48±4.18)％,实验组低于对照组(P＜0.05),组织坏死比例分别为(32.19±1.21)％和(29.16±2.16)％,实验组高于对照组(P＜0.05).ADC值与细胞密度呈负相关(r=-0.703,P＜0.001),与组织坏死比例呈正相关(r=0.658,P=0.003).结论 单次大剂量放射治疗可以抑制食管癌荷瘤裸鼠肿瘤生长,ADC值可以先于肿瘤形态学变化而发生改变.移植瘤细胞密度和组织坏死比例的变化与ADC值的变化基本吻合.MR-DWI技术具有早期预测食管癌放疗疗效的价值. |
| Abstract_FL | Objective To explore the value of diffusion-weighted magnetic resonance imaging (MRDWI) technique in predicting the efficacy of radiotherapy in patients with esophageal cancer,using experimental animal models.Methods BALB/c nude mice were subcutaneously injected with Eca-109 cell lines and then tumor formed.The experimental group (16 cases) received a single dose of 15 Gy (6 MV Xrays) delivered by a medical linear accelerator,while the control group (24 cases) did not receive any treatment.The two groups were scanned every other day,started one day before the radiotherapy.The scanning sequences included T1-weight imaging,T2-weight imaging,and DWI.The observation time was 1 month.According to the changes of the tumor volume and apparent diffusion coefficient (ADC) value of the two groups,7 key time points were selected to observe the difference of cell density and tissue necrosis ratio between the two groups (6 cases in each group).Results From day 7 after radiotherapy,the experimental group had statistically smaller volume of transplanted tumors than the control group,namely (1.729±0.906) cm3 vs (2.671 ±0.915) cm3 (P＜ 0.05).From day 3 after radiotherapy,the experimental group had statistically higher ADC values [(1.017± 0.255) × 10-6 vs (0.833± 0.142) × 10-6 mm2/s,P＜0.05],lower cell density of transplanted tumor (25.56± 1.40 vs 33.48±4.18％,P＜0.05),and less proportion of tissue necrosis [(32.19 ± 1.21) ％ vs (29.16 ± 2.16) ％,P＜ 0.05],respectively.The ADC value was negatively correlated with cell density (r=-0.703,P＜0.001) and positively correlated with tissue necrosis ratio (r=0.658,P=0.003).Conclusions Single dose of large fraction radiotherapy could inhibit the growth of xenograft.ADC values may change at the early stage prior to morphological changes of tumor.The change of cell density and necrosis ratio of transplanted tumor are in line with the change of ADC value.MR-DWI has the value of early prediction of esophageal cancer radiotherapy efficacy. |
| Author | 李扬 王燕飞 张钧 刘辉 张安度 韩春 时高峰 王澜 |
| AuthorAffiliation | 河北医科大学第四医院放疗科,石家庄,050011%河北医科大学第四医院CT与MRI科,石家庄,050011 |
| AuthorAffiliation_xml | – name: 河北医科大学第四医院放疗科,石家庄,050011%河北医科大学第四医院CT与MRI科,石家庄,050011 |
| Author_FL | Han Chun Zhang Andu Liu Hui Li Yang Zhang Jun Shi Gaofeng Wang Lan Wang Yanfei |
| Author_FL_xml | – sequence: 1 fullname: Zhang Andu – sequence: 2 fullname: Wang Yanfei – sequence: 3 fullname: Shi Gaofeng – sequence: 4 fullname: Han Chun – sequence: 5 fullname: Zhang Jun – sequence: 6 fullname: Wang Lan – sequence: 7 fullname: Liu Hui – sequence: 8 fullname: Li Yang |
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| Keywords | Nude mice Diffusion-weighted magnetic resonance imaging 表观弥散系数 放射疗法 裸鼠 食管肿瘤 Esophageal neoplasms 磁共振弥散加权成像 Radiotherapy Apparent diffusion coefficient |
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