中药单体成分及复方促进骨折愈合的作用机制研究进展

R965%R285; 中药在治疗骨折愈合过程中具有多成分、多途径、多靶点的作用特点,对于具有复杂病理机制的骨折具有较好的治疗优势和潜力.笔者对中药单体成分及复方促进骨折愈合的作用机制进行了归纳,发现内脂素A、葛根素等可通过激活丝裂原活化蛋白激酶(MAPK)信号通路,续骨丹、固本增骨方等可通过激活骨形态发生蛋白(BMP)信号通路,黄芩苷、牛膝多糖等可通过激活Wnt/β-catenin信号通路,芹菜素、三七皂苷等可通过激活核因子κB(NF-κB)受体激活蛋白/NF-κB受体激活蛋白配体/护骨因子(RANK/RANKL/OPG)信号通路,活血接骨复方胶囊、健骨颗粒等可通过抑制磷脂酰肌醇3-激酶/蛋白...

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Published in中国药房 Vol. 34; no. 17; pp. 2172 - 2176
Main Authors 张志宏, 孙延平, 彭东辉, 崔娜, 曾元宁, 匡海学, 王秋红
Format Journal Article
LanguageChinese
Published 黑龙江中医药大学药学院教育部北药基础与应用研究重点实验室,哈尔滨 150040%广东药科大学中药学院,广州 510006 01.09.2023
Subjects
compound formulas
单体成分
monomer components
osteogenic differentiation
复方
信号通路
signaling pathway
traditional Chinese medicine
成骨分化
中药
骨折愈合
fracture healing
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ISSN1001-0408
DOI10.6039/j.issn.1001-0408.2023.17.22

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Abstract R965%R285; 中药在治疗骨折愈合过程中具有多成分、多途径、多靶点的作用特点,对于具有复杂病理机制的骨折具有较好的治疗优势和潜力.笔者对中药单体成分及复方促进骨折愈合的作用机制进行了归纳,发现内脂素A、葛根素等可通过激活丝裂原活化蛋白激酶(MAPK)信号通路,续骨丹、固本增骨方等可通过激活骨形态发生蛋白(BMP)信号通路,黄芩苷、牛膝多糖等可通过激活Wnt/β-catenin信号通路,芹菜素、三七皂苷等可通过激活核因子κB(NF-κB)受体激活蛋白/NF-κB受体激活蛋白配体/护骨因子(RANK/RANKL/OPG)信号通路,活血接骨复方胶囊、健骨颗粒等可通过抑制磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/AKT)信号通路,淫羊藿苷等可通过激活Notch信号通路,桃红四物汤、藏红花素等可通过激活Hippo信号通路,酸枣仁皂苷A、蛇床子素等可通过抑制NF-κB信号通路,发挥促进骨折愈合的作用.
AbstractList R965%R285; 中药在治疗骨折愈合过程中具有多成分、多途径、多靶点的作用特点,对于具有复杂病理机制的骨折具有较好的治疗优势和潜力.笔者对中药单体成分及复方促进骨折愈合的作用机制进行了归纳,发现内脂素A、葛根素等可通过激活丝裂原活化蛋白激酶(MAPK)信号通路,续骨丹、固本增骨方等可通过激活骨形态发生蛋白(BMP)信号通路,黄芩苷、牛膝多糖等可通过激活Wnt/β-catenin信号通路,芹菜素、三七皂苷等可通过激活核因子κB(NF-κB)受体激活蛋白/NF-κB受体激活蛋白配体/护骨因子(RANK/RANKL/OPG)信号通路,活血接骨复方胶囊、健骨颗粒等可通过抑制磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/AKT)信号通路,淫羊藿苷等可通过激活Notch信号通路,桃红四物汤、藏红花素等可通过激活Hippo信号通路,酸枣仁皂苷A、蛇床子素等可通过抑制NF-κB信号通路,发挥促进骨折愈合的作用.
Author 曾元宁
王秋红
崔娜
孙延平
匡海学
张志宏
彭东辉
AuthorAffiliation 黑龙江中医药大学药学院教育部北药基础与应用研究重点实验室,哈尔滨 150040%广东药科大学中药学院,广州 510006
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CUI Na
WANG Qiuhong
ZHANG Zhihong
PENG Donghui
SUN Yanping
ZENG Yuanning
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Keywords compound formulas
单体成分
monomer components
osteogenic differentiation
复方
信号通路
signaling pathway
traditional Chinese medicine
成骨分化
中药
骨折愈合
fracture healing
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