艾拉莫德应用于结缔组织病的作用机制与临床研究进展

R979.5; 艾拉莫德作为一种新型免疫抑制剂,可通过抑制炎症细胞增殖和减少炎症细胞因子释放的方式介导抗炎信号通路,发挥抗炎作用;可通过影响免疫细胞增殖及免疫因子表达,减少机体免疫复合物的产生及沉积,发挥调节免疫作用;可通过介导Wnt/β-连环蛋白、Toll样受体4/核因子κB和护骨因子/核因子κB受体活化因子配体等信号通路调节骨代谢,发挥骨保护作用;可通过抑制转化生长因子β1/Smad2/3信号通路及肿瘤坏死因子α、白细胞介素1、白细胞介素6和基质金属蛋白酶9等炎症细胞因子在肺组织的表达并抑制胶原蛋白及纤连蛋白的表达,发挥抑制肺纤维化作用.其疗效及安全性在类风湿性关节炎和原发性干燥综合征的临...

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Published in中国药房 Vol. 35; no. 5; pp. 629 - 634
Main Authors 杨晓蓉, 周淑红, 郭莉江, 陈英, 冀盈盈, 许丽洁
Format Journal Article
LanguageChinese
Published 甘肃中医药大学第一临床医学院,兰州730030 01.03.2024
甘肃省人民医院中西医结合免疫风湿科,兰州 730030%甘肃省人民医院中西医结合免疫风湿科,兰州 730030
Subjects
临床应用
clinical application
艾拉莫德
iguratimod
mechanism of action
结缔组织病
作用机制
connective tissue disease
Online AccessGet full text
ISSN1001-0408
DOI10.6039/j.issn.1001-0408.2024.05.21

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Abstract R979.5; 艾拉莫德作为一种新型免疫抑制剂,可通过抑制炎症细胞增殖和减少炎症细胞因子释放的方式介导抗炎信号通路,发挥抗炎作用;可通过影响免疫细胞增殖及免疫因子表达,减少机体免疫复合物的产生及沉积,发挥调节免疫作用;可通过介导Wnt/β-连环蛋白、Toll样受体4/核因子κB和护骨因子/核因子κB受体活化因子配体等信号通路调节骨代谢,发挥骨保护作用;可通过抑制转化生长因子β1/Smad2/3信号通路及肿瘤坏死因子α、白细胞介素1、白细胞介素6和基质金属蛋白酶9等炎症细胞因子在肺组织的表达并抑制胶原蛋白及纤连蛋白的表达,发挥抑制肺纤维化作用.其疗效及安全性在类风湿性关节炎和原发性干燥综合征的临床应用中已得到肯定并纳入了疾病的诊疗规范中;其在系统性红斑狼疮和强直性脊柱炎等其他结缔组织病的临床应用过程中同样表现出良好的疗效,且尚未发现明显的安全隐患.
AbstractList R979.5; 艾拉莫德作为一种新型免疫抑制剂,可通过抑制炎症细胞增殖和减少炎症细胞因子释放的方式介导抗炎信号通路,发挥抗炎作用;可通过影响免疫细胞增殖及免疫因子表达,减少机体免疫复合物的产生及沉积,发挥调节免疫作用;可通过介导Wnt/β-连环蛋白、Toll样受体4/核因子κB和护骨因子/核因子κB受体活化因子配体等信号通路调节骨代谢,发挥骨保护作用;可通过抑制转化生长因子β1/Smad2/3信号通路及肿瘤坏死因子α、白细胞介素1、白细胞介素6和基质金属蛋白酶9等炎症细胞因子在肺组织的表达并抑制胶原蛋白及纤连蛋白的表达,发挥抑制肺纤维化作用.其疗效及安全性在类风湿性关节炎和原发性干燥综合征的临床应用中已得到肯定并纳入了疾病的诊疗规范中;其在系统性红斑狼疮和强直性脊柱炎等其他结缔组织病的临床应用过程中同样表现出良好的疗效,且尚未发现明显的安全隐患.
Author 冀盈盈
许丽洁
周淑红
郭莉江
陈英
杨晓蓉
AuthorAffiliation 甘肃中医药大学第一临床医学院,兰州730030;甘肃省人民医院中西医结合免疫风湿科,兰州 730030%甘肃省人民医院中西医结合免疫风湿科,兰州 730030
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Author_FL ZHOU Shuhong
CHEN Ying
JI Yingying
XU Lijie
YANG Xiaorong
GUO Lijiang
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Keywords 临床应用
clinical application
艾拉莫德
iguratimod
mechanism of action
结缔组织病
作用机制
connective tissue disease
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Publisher 甘肃中医药大学第一临床医学院,兰州730030
甘肃省人民医院中西医结合免疫风湿科,兰州 730030%甘肃省人民医院中西医结合免疫风湿科,兰州 730030
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Title 艾拉莫德应用于结缔组织病的作用机制与临床研究进展
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