气相色谱-正化学电离源-飞行时间质谱法测定烟草吸食者唾液中的吡嗪和吡啶类物质

O657.63; 建立了气相色谱-正化学电离源-飞行时间质谱法(GC-PCI-TOF MS)测定烟草吸食者唾液中9种吡嗪和吡啶类物质.样品经二氯甲烷溶剂萃取,N-丙基乙二胺(PSA)吸附剂分散固相萃取净化后,进行GC-PCI-TOF MS检测.结合特征离子的保留时间、精确质量数、裂解规律对目标物进行定性分析,以外标法定量.结果表明:9种吡嗪和吡啶类物质的线性相关系数R2均大于0.9991,定量限为3.0～7.9μg/L,回收率在85％ ～104％ 之间;烟草吸食者唾液中含量较高的吡嗪和吡啶类物质为吡啶、2-甲基吡嗪,二甲基吡嗪类有少量检出;不同卷烟样品吸食者唾液中吡啶和2-甲基吡嗪的含量存在明...

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Published in质谱学报 Vol. 39; no. 4; pp. 467 - 475
Main Authors 司晓喜, 张凤梅, 朱瑞芝, 刘春波, 申钦鹏, 尤俊衡, 张涛, 缪明明, 刘志华
Format Journal Article
LanguageChinese
Published 云南中烟工业有限责任公司技术中心,云南省烟草化学重点实验室,云南昆明 650231 01.07.2018
Subjects
气相色谱-正化学源-飞行时间质谱(GC-PCI-TOFMS)
吡嗪
烟气
烟草
唾液
吡啶
Online AccessGet full text
ISSN1004-2997
DOI10.7538/zpxb.2017.0152

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Abstract O657.63; 建立了气相色谱-正化学电离源-飞行时间质谱法(GC-PCI-TOF MS)测定烟草吸食者唾液中9种吡嗪和吡啶类物质.样品经二氯甲烷溶剂萃取,N-丙基乙二胺(PSA)吸附剂分散固相萃取净化后,进行GC-PCI-TOF MS检测.结合特征离子的保留时间、精确质量数、裂解规律对目标物进行定性分析,以外标法定量.结果表明:9种吡嗪和吡啶类物质的线性相关系数R2均大于0.9991,定量限为3.0～7.9μg/L,回收率在85％ ～104％ 之间;烟草吸食者唾液中含量较高的吡嗪和吡啶类物质为吡啶、2-甲基吡嗪,二甲基吡嗪类有少量检出;不同卷烟样品吸食者唾液中吡啶和2-甲基吡嗪的含量存在明显差异.对不同类型卷烟样品吸食者唾液中吡嗪和吡啶类物质含量进行主成分分析,发现同种卷烟中二者含量能很好地聚类,不同卷烟中二者含量存在显著性差异(P<0.05),因此可以按吸食者唾液中吡嗪和吡啶类含量对卷烟进行分类.
AbstractList O657.63; 建立了气相色谱-正化学电离源-飞行时间质谱法(GC-PCI-TOF MS)测定烟草吸食者唾液中9种吡嗪和吡啶类物质.样品经二氯甲烷溶剂萃取,N-丙基乙二胺(PSA)吸附剂分散固相萃取净化后,进行GC-PCI-TOF MS检测.结合特征离子的保留时间、精确质量数、裂解规律对目标物进行定性分析,以外标法定量.结果表明:9种吡嗪和吡啶类物质的线性相关系数R2均大于0.9991,定量限为3.0～7.9μg/L,回收率在85％ ～104％ 之间;烟草吸食者唾液中含量较高的吡嗪和吡啶类物质为吡啶、2-甲基吡嗪,二甲基吡嗪类有少量检出;不同卷烟样品吸食者唾液中吡啶和2-甲基吡嗪的含量存在明显差异.对不同类型卷烟样品吸食者唾液中吡嗪和吡啶类物质含量进行主成分分析,发现同种卷烟中二者含量能很好地聚类,不同卷烟中二者含量存在显著性差异(P<0.05),因此可以按吸食者唾液中吡嗪和吡啶类含量对卷烟进行分类.
Author 张涛
缪明明
朱瑞芝
刘春波
司晓喜
申钦鹏
张凤梅
尤俊衡
刘志华
AuthorAffiliation 云南中烟工业有限责任公司技术中心,云南省烟草化学重点实验室,云南昆明 650231
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Author_FL SI Xiao-xi
LIU Zhi-hua
SHEN Qin-peng
LIU Chun-bo
ZHANG Tao
ZHANG Feng-mei
YOU Jun-heng
ZHU Rui-zhi
MIAO Ming-ming
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Keywords 气相色谱-正化学源-飞行时间质谱(GC-PCI-TOFMS)
吡嗪
烟气
烟草
唾液
吡啶
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Snippet O657.63; 建立了气相色谱-正化学电离源-飞行时间质谱法(GC-PCI-TOF MS)测定烟草吸食者唾液中9种吡嗪和吡啶类物质.样品经二氯甲烷溶剂萃取,N-丙基乙二胺(PSA)吸附剂分散固相萃取净化后,进行GC-PCI-TOF...
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Title 气相色谱-正化学电离源-飞行时间质谱法测定烟草吸食者唾液中的吡嗪和吡啶类物质
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