基于MC-ICP-MS的稳定铜同位素分析在环境健康研究中的应用进展
O657.63; 铜(Cu)是人体内重要的微量金属元素之一,在许多生命过程中扮演着重要角色;同时,铜在人体内受到严格调控,其稳态与人体生理状态密切相关,许多疾病的发生往往伴随着铜代谢失衡的现象.通过监测铜稳态的细微变化,可以更精准地发现导致人体生理异常变化的因素,特别是环境因素对疾病发生及发展的影响.因此,稳定铜同位素分析在环境健康研究中具有广泛的应用前景.多接收器电感耦合等离子体质谱(MC-ICP-MS)是一种强大的同位素分析质谱方法,具有适用范围广、分析精度高等优点,有效促进了铜同位素分析的发展.本文综述了非传统稳定同位素分馏机理及基于MC-ICP-MS的铜同位素分析方法,总结了铜同位素分...
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| Published in | 质谱学报 Vol. 45; no. 2; pp. 183 - 192 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京 100085%中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京 100085%国科大杭州高等研究院环境学院,浙江杭州 310024
01.03.2024
国科大杭州高等研究院环境学院,浙江杭州 310024 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1004-2997 |
| DOI | 10.7538/zpxb.2023.0143 |
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| Abstract | O657.63; 铜(Cu)是人体内重要的微量金属元素之一,在许多生命过程中扮演着重要角色;同时,铜在人体内受到严格调控,其稳态与人体生理状态密切相关,许多疾病的发生往往伴随着铜代谢失衡的现象.通过监测铜稳态的细微变化,可以更精准地发现导致人体生理异常变化的因素,特别是环境因素对疾病发生及发展的影响.因此,稳定铜同位素分析在环境健康研究中具有广泛的应用前景.多接收器电感耦合等离子体质谱(MC-ICP-MS)是一种强大的同位素分析质谱方法,具有适用范围广、分析精度高等优点,有效促进了铜同位素分析的发展.本文综述了非传统稳定同位素分馏机理及基于MC-ICP-MS的铜同位素分析方法,总结了铜同位素分析在环境健康研究中的主要应用,并对其前景进行展望. |
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| AbstractList | O657.63; 铜(Cu)是人体内重要的微量金属元素之一,在许多生命过程中扮演着重要角色;同时,铜在人体内受到严格调控,其稳态与人体生理状态密切相关,许多疾病的发生往往伴随着铜代谢失衡的现象.通过监测铜稳态的细微变化,可以更精准地发现导致人体生理异常变化的因素,特别是环境因素对疾病发生及发展的影响.因此,稳定铜同位素分析在环境健康研究中具有广泛的应用前景.多接收器电感耦合等离子体质谱(MC-ICP-MS)是一种强大的同位素分析质谱方法,具有适用范围广、分析精度高等优点,有效促进了铜同位素分析的发展.本文综述了非传统稳定同位素分馏机理及基于MC-ICP-MS的铜同位素分析方法,总结了铜同位素分析在环境健康研究中的主要应用,并对其前景进行展望. |
| Abstract_FL | Copper(Cu)is a crucial trace metal element in human body,which plays an important role in many life processes.Meanwhile,copper is strictly regulated in the human body and its homeostasis is closely related to the physiological state.The occur-rences of many diseases are often accompanied by the copper imbalance.By monitoring the subtle variation in copper homeostasis,it can more accurately identify the factors that lead to abnormal changes in human physiology,especially the impact of environ-mental factors on the occurrence and development of diseases.In the past two decades,with the development of analytical instruments and improvement of analytical methods,non-traditional stable isotopic analysis has been widely applied in geochemistry and archaeology.Owing to its strong traceability,non-traditional stable isotopic analysis can also provide a new perspective to reveal the mechanisms of element homeostasis imbal-ance.Especially,stable copper isotopic analysis has a wide application prospect in environmental health research.Because of the virtues of wide application range and high analytical accuracy,multi-collector inductively coupled plasma mass spectrometry(MC-ICP-MS)has effectively promoted the process of copper isotopic analysis.In this paper,we reviewed the mechanisms of non-traditional stable isotope fractionation and analysis methods of Cu isotopes based on MC-ICP-MS,and the basic conception of mass depend-ent fractionation(MDF)and non-mass dependent fractionation(MIF)as well as the instrumental configuration of MC-ICP-MS.We also introduced the methods of copper isotopic analysis,and then summarized the main applications of copper isotopic analysis in environmental health research.We focused on two aspects,i.e.,Cu isotopic analysis of population characteristics and research on disease indicators.In summarizing the rele-vant researches of Cu isotopic analysis of population characteristics,we reviewed the influence factors,such as age,gender,dietary habits,and other factors.Afterwards,the studies of copper isotopic analysis on some diseases,such as cancers,nervous disea-ses,disorders of copper transporters,and other diseases were summarized.Finally,we discussed the application prospects of copper isotopic analysis in environmental health research.Until now,the application of stable copper isotopic analysis in environmental health is still in the initial stage,and there still exist many difficulties and challenges.We primarily list four main difficulties and challenges in future studies,including high-throughput sample analysis,background population investigation,combination of other clinical indicators,and combination of multiple omics techniques. |
| Author | 陈子谷 陆达伟 张璐瑶 杨学志 傅建捷 王伟超 江桂斌 刘倩 令伟博 |
| AuthorAffiliation | 国科大杭州高等研究院环境学院,浙江杭州 310024;中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京 100085%中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京 100085%国科大杭州高等研究院环境学院,浙江杭州 310024 |
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| Author_FL | LU Da-wei YANG Xue-zhi CHEN Zi-gu LIU Qian LING Wei-bo JIANG Gui-bin WANG Wei-chao FU Jian-jie ZHANG Lu-yao |
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| DocumentTitle_FL | Advances in the Application of Stable Copper Isotopic Analysis Based on MC-ICP-MS in Environmental Health Research |
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| Keywords | 质谱分析 稳定同位素 多接收器电感耦合等离子体质谱(MC-ICP-MS) multi-collector inductively coupled plasma mass spectrometry(MC-ICP-MS) copper mass spectrometry 环境健康 stable isotope 铜 environmental health |
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| Title | 基于MC-ICP-MS的稳定铜同位素分析在环境健康研究中的应用进展 |
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