Unbiased Quantitative Proteomics of Organoid Models of Pancreatic Cancer

• Published in: Methods in molecular biology (Clifton, N.J.) Vol. 2823; p. 77
• Main Authors: Low, Ronnie Ren Jie, Fung, Ka Yee, Dagley, Laura F, Yousef, Jumana, Emery-Corbin, Samantha J, Putoczki, Tracy L
• Format: Journal Article
• Language: English
• Published: United States 2024
• Subjects: Animals; Biomarkers, Tumor - metabolism; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; Humans; Mice; Organoids - metabolism; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Proteome; Proteomics - methods; Model; Organoid; FACs; Pancreatic cancer; Proteomics

Pancreatic ductal adenocarcinoma (PDAC) is a lethal solid malignancy with many patients succumbing to the disease within 6 months of diagnosis. The mechanisms that underlie PDAC initiation and progression are poorly understood. Current treatment options are primarily limited to chemotherapy, which i...