Basic Science and Pathogenesis

• Published in: Alzheimer's & dementia Vol. 20 Suppl 1; p. e093457
• Main Authors: Jin, Bowen, Naik, Samuel, Kirkham, Samantha L, Qian, Xuyu, Zhou, Zinan, Oakley, Derek, Frosch, Matt P, Hyman, Bradley T T, Huang, August Yue, Miller, Michael B
• Format: Journal Article
• Language: English
• Published: United States 01.12.2024
• Subjects: Aged; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Brain - metabolism; Brain - pathology; Cell Nucleus - metabolism; Female; Humans; Male; Neurons - metabolism; Neurons - pathology; Phosphorylation; tau Proteins - metabolism

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the deposition of amyloid-beta and hyperphosphorylated tau (P-tau) proteins in the brain. P-tau accumulates in neurons and is strongly associated with AD severity and affected brain regions. However, only a su...