Basic Science and Pathogenesis

• Published in: Alzheimer's & dementia Vol. 20 Suppl 1; p. e088489
• Main Authors: Kikuchi, Masataka, Miyashita, Akinori, Hirota, Yu, Hara, Norikazu, Hasegawa, Mai, Sakakibara, Yasufumi, Sekiya, Michiko, Saito, Yuko, Murayama, Shigeo, Iijima, Koichi M, Ikeuchi, Takeshi
• Format: Journal Article
• Language: English
• Published: United States 01.12.2024
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Autopsy; Brain - pathology; Female; Humans; Male; Membrane Glycoproteins - genetics; Microglia - metabolism; Microglia - pathology; Multifactorial Inheritance - genetics; Mutation; Neurofibrillary Tangles - pathology; Plaque, Amyloid - pathology; Receptors, Immunologic - genetics; Receptors, Immunologic - metabolism
• ISSN: 1552-5279
• DOI: 10.1002/alz.088489

Recent single-cell omics analyses have revealed that microglia change into reactive microglia when Aβ accumulates in the brain and exhibit Aβ phagocytosis. However, reactive microglia are less likely to be induced in TREM2 mutation carriers. This microglia-centred pathological mechanism may be consi...