Association of blood group A with hospital comorbidity in patients infected by SARS-CoV-2

• Published in: Medicina clinica Vol. 159; no. 1; p. 27
• Main Authors: Tamayo-Velasco, Álvaro, Jiménez García, María Teresa, Sánchez Rodríguez, Alba, Hijas Villaizan, Milagros, Carretero Gómez, Juana, Miramontes-González, José Pablo
• Format: Journal Article
• Language: English
• Published: Spain 08.07.2022
• Subjects: Blood Group Antigens; Comorbidity; COVID-19 - complications; COVID-19 - epidemiology; Hospital Mortality; Hospitals; Humans; Prospective Studies; SARS-CoV-2; COVID-19; Charlson Index; Índice de Charlson; Mortality; Mortalidad; Grupos sanguíneos; Blood groups
• ISSN: 1578-8989
• DOI: 10.1016/j.medcli.2021.06.017

In the pandemic caused by SARS-CoV-2, identifying which risk factors are associated with the most serious forms of the disease is important. Blood group A has been presented in various studies as a poor prognostic factor. The objective of this study was to evaluate whether patients with blood group A were associated with more important comorbidities, measured by the Charlson Index, which may explain their worse clinical evolution. A prospective and consecutive study examined 100 patients diagnosed with COVID-19 and admitted in March 2020. A multivariate linear regression model was used to evaluate the association of blood group A with the Charlson Index. Patients in group A had a higher Charlson Index (P=.037), rate of lymphopenia (P=.039) and thrombopenia (P=.014), and hospital mortality (P=.044). Blood group A was an independent factor associated with the Charlson Index (B 0.582, 95% CI 0.02-1.14, P=0.041). Group A was independently associated with greater comorbidity, associated with an increase of 0.582 points in the Charlson Index compared to other blood groups. It was also associated with lower hospital mortality.