Basic Science and Pathogenesis

• Published in: Alzheimer's & dementia Vol. 20 Suppl 1; p. e089488
• Main Authors: Dauar, Marina Tedeschi, Picard, Cynthia, Labonte, Anne, Villeneuve, Sylvia, Poirier, Judes, Group, Prevent-Ad Research
• Format: Journal Article
• Language: English
• Published: United States 01.12.2024
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Amyloid beta-Peptides - cerebrospinal fluid; Amyloid beta-Peptides - metabolism; Biomarkers - cerebrospinal fluid; Brain - metabolism; Brain - pathology; Clusterin - cerebrospinal fluid; Clusterin - genetics; Female; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Positron-Emission Tomography; tau Proteins - cerebrospinal fluid
• ISSN: 1552-5279
• DOI: 10.1002/alz.089488

Clusterin is a major cholesterol transporter in the central nervous system (CNS) and different SNPs in the CLU gene have been associated with Alzheimer's disease (AD) risk. The rs11136000_T variant in the CLU gene has been shown to decrease the risk of AD. In this work, we investigate the role...