Basic Science and Pathogenesis

• Published in: Alzheimer's & dementia Vol. 20 Suppl 1; p. e084126
• Main Author: Solomon, Beka
• Format: Journal Article
• Language: English
• Published: United States 01.12.2024
• Subjects: Alzheimer Disease; Amyloid beta-Peptides - metabolism; Animals; Antibodies, Monoclonal; Humans

Amyloid filaments formation is a complex kinetic and thermodynamic process. The dependence of peptide polymerization on peptide-peptide interactions to form a β-pleated sheet fibrils and the stimulatory influence of other proteins on the reaction suggest that amyloid formation may be subject to modu...