Synthesis, characterization and evaluation of antileishmanial activity of copper(II) with fluorinated [alpha]-hydroxycarboxylate ligands

• Published in: Biometals Vol. 22; no. 6; pp. 1095 - 1101
• Main Authors: Da Silva Maffei, Rodrigo, Yokoyama-yasunaka, Jenicer K; U, Miguel, Danilo Ciccone, Uliana, Silvia Reni; Bortolin, Espósito, Breno Pannia
• Format: Journal Article
• Language: English; Dutch
• Published: Dordrecht Springer Nature B.V 01.12.2009
• Subjects: Chemotherapy; Copper; Crystallization; Enzymes; Infections; Leishmania amazonensis; Metals; Protozoa; Spectrum analysis; Vector-borne diseases

In this study, Cu(II) complexes with fluorinated ligands were produced aiming at the development of new, less toxic antileishmanial metallodrugs. Complexes of the general formula CuL2 (L = lactate, trifluorolactate, 2-hydroxyisobutyrate, trifluoro-2-hydroxyisobutyrate) were synthesized in methanolic...