Synthesis, characterization and evaluation of antileishmanial activity of copper(II) with fluorinated [alpha]-hydroxycarboxylate ligands

In this study, Cu(II) complexes with fluorinated ligands were produced aiming at the development of new, less toxic antileishmanial metallodrugs. Complexes of the general formula CuL2 (L = lactate, trifluorolactate, 2-hydroxyisobutyrate, trifluoro-2-hydroxyisobutyrate) were synthesized in methanolic...

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Published inBiometals Vol. 22; no. 6; pp. 1095 - 1101
Main Authors Da Silva Maffei, Rodrigo, Yokoyama-yasunaka, Jenicer K; U, Miguel, Danilo Ciccone, Uliana, Silvia Reni; Bortolin, Espósito, Breno Pannia
Format Journal Article
LanguageEnglish
Dutch
Published Dordrecht Springer Nature B.V 01.12.2009
Subjects
Chemotherapy
Copper
Crystallization
Enzymes
Infections
Leishmania amazonensis
Metals
Protozoa
Spectrum analysis
Vector-borne diseases
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Summary:In this study, Cu(II) complexes with fluorinated ligands were produced aiming at the development of new, less toxic antileishmanial metallodrugs. Complexes of the general formula CuL2 (L = lactate, trifluorolactate, 2-hydroxyisobutyrate, trifluoro-2-hydroxyisobutyrate) were synthesized in methanolic medium, purified by crystallization and characterized by elemental analysis and electronic and infrared spectroscopies. In vitro experiments with Leishmania amazonensis promastigotes showed that the trifluorolactate derivative more active than its non-fluorinated counterpart. Our results indicate that fluorinated chelators may be interesting to increase metal toxicity and/or open new paths for metallodrug chemotherapy against leishmaniasis. [PUBLICATION ABSTRACT]
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ISSN:0966-0844
1572-8773
DOI:10.1007/s10534-009-9260-1