长脉冲1064nm Nd∶YAG激光联合特比萘芬治疗Fonsecaea nubica所致着色芽生菌病及其对大鼠模型作用
报道长脉冲1064 nm Nd∶YAG激光联合特比萘芬成功治疗Fonsecaea nubica所致着色芽生菌病1例,并探讨Enubica的真菌学、体外药敏试验和动物实验特点.患者,男,60岁,右手背约30 minx40 mm暗红色斑块10个月,无痒痛.皮损KOH直接镜检、组织病理见特征性的硬壳小体;沙堡培养基26℃培养2周见灰黑色绒毛状菌落,小培养镜下见着色霉属特征性枝孢样产孢结构.对所分离的致病菌株进行ITS序列测序鉴定为Enubica.采用M38-A2方案对该致病菌进行9种抗真菌药物的体外药敏试验,结果显示特比萘芬MIC值最小(0.125 μg/mL).我们应用该Enubica菌株成功构建...
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| Published in | Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 39; no. 6; pp. 712 - 717 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | Chinese English |
| Published |
中国广东
南方医科大学第三附属医院皮肤科,广东广州,510630%中山大学附属第三医院皮肤科,广东广州,510630
20.06.2019
南方医科大学学报编辑部 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1673-4254 2663-0842 |
| DOI | 10.12122/j.issn.1673-4254.2019.06.13 |
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| Abstract | 报道长脉冲1064 nm Nd∶YAG激光联合特比萘芬成功治疗Fonsecaea nubica所致着色芽生菌病1例,并探讨Enubica的真菌学、体外药敏试验和动物实验特点.患者,男,60岁,右手背约30 minx40 mm暗红色斑块10个月,无痒痛.皮损KOH直接镜检、组织病理见特征性的硬壳小体;沙堡培养基26℃培养2周见灰黑色绒毛状菌落,小培养镜下见着色霉属特征性枝孢样产孢结构.对所分离的致病菌株进行ITS序列测序鉴定为Enubica.采用M38-A2方案对该致病菌进行9种抗真菌药物的体外药敏试验,结果显示特比萘芬MIC值最小(0.125 μg/mL).我们应用该Enubica菌株成功构建了模拟临床的着色芽生菌病Wistar大鼠模型,并使用长脉冲1064 nm Nd:YAG激光(脉宽3.0 ms、能量24 J/em2、光斑直径3mm,频率4Hz,间隔30 s,照射共3轮)治疗,2次/周连续8次后停用,结果显示经过8次照射可诱导病变组织局部大量淋巴细胞聚集,促进病变恢复,但不能杀灭真菌.临床上,患者经长脉冲1064 nm Nd∶YAG激光照射(1次/周,剂量同上)联合口服特比萘芬0.25 Bid治疗共8周后皮损明显好转,复查真菌学阴性,随访20月无复发. |
|---|---|
| AbstractList | 报道长脉冲1064 nm Nd：YAG激光联合特比萘芬成功治疗
Fonsecaea nubica
所致着色芽生菌病1例，并探讨
F.nubica
的真菌学、体外药敏试验和动物实验特点。患者，男，60岁，右手背约30 mm×40 mm暗红色斑块10个月，无痒痛。皮损KOH直接镜检、组织病理见特征性的硬壳小体；沙堡培养基26 ℃培养2周见灰黑色绒毛状菌落，小培养镜下见着色霉属特征性枝孢样产孢结构。对所分离的致病菌株进行ITS序列测序鉴定为
F.nubica
。采用M38-A2方案对该致病菌进行9种抗真菌药物的体外药敏试验，结果显示特比萘芬MIC值最小（0.125 μg/mL）。我们应用该
F.nubica
菌株成功构建了模拟临床的着色芽生菌病Wistar大鼠模型，并使用长脉冲1064 nm Nd：YAG激光（脉宽3.0 ms、能量24 J/cm
2
、光斑直径3 mm，频率4 Hz，间隔30 s，照射共3轮）治疗，2次/周连续8次后停用，结果显示经过8次照射可诱导病变组织局部大量淋巴细胞聚集，促进病变恢复，但不能杀灭真菌。临床上，患者经长脉冲1064 nm Nd：YAG激光照射（1次/周，剂量同上）联合口服特比萘芬0.25 Bid治疗共8周后皮损明显好转，复查真菌学阴性，随访20月无复发。 报道长脉冲1064 nm Nd∶YAG激光联合特比萘芬成功治疗Fonsecaea nubica所致着色芽生菌病1例,并探讨Enubica的真菌学、体外药敏试验和动物实验特点.患者,男,60岁,右手背约30 minx40 mm暗红色斑块10个月,无痒痛.皮损KOH直接镜检、组织病理见特征性的硬壳小体;沙堡培养基26℃培养2周见灰黑色绒毛状菌落,小培养镜下见着色霉属特征性枝孢样产孢结构.对所分离的致病菌株进行ITS序列测序鉴定为Enubica.采用M38-A2方案对该致病菌进行9种抗真菌药物的体外药敏试验,结果显示特比萘芬MIC值最小(0.125 μg/mL).我们应用该Enubica菌株成功构建了模拟临床的着色芽生菌病Wistar大鼠模型,并使用长脉冲1064 nm Nd:YAG激光(脉宽3.0 ms、能量24 J/em2、光斑直径3mm,频率4Hz,间隔30 s,照射共3轮)治疗,2次/周连续8次后停用,结果显示经过8次照射可诱导病变组织局部大量淋巴细胞聚集,促进病变恢复,但不能杀灭真菌.临床上,患者经长脉冲1064 nm Nd∶YAG激光照射(1次/周,剂量同上)联合口服特比萘芬0.25 Bid治疗共8周后皮损明显好转,复查真菌学阴性,随访20月无复发. |
| Author | 胡永轩 罗娟 周思彤 Jadad Abdullah 钟泽敏 刘康兴 周冼苡 冯佩英 郑雨诗 杨烨玫 胡燕卿 卢艳 黄松根 |
| AuthorAffiliation | 南方医科大学第三附属医院皮肤科,广东广州,510630%中山大学附属第三医院皮肤科,广东广州,510630 |
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| Author_FL | ZHONG Zemin LU Yan ZHOU Xianyi ZHENG Yushi YANG Yemei ZHOU Sitong LIU Kangxing FENG Peiying LUO Juan HU Yongxuan HUANG Songgen Jadad Abdulla HU Yanqing |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. 版权所有©《南方医科大学学报》编辑部2019 Copyright ©2019 Journal of Southern Medical University. All rights reserved. 2019 |
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| DocumentTitle_FL | Long-pulsed 1064 nm Nd∶YAG laser combined with terbinafine against chromoblastomycosis caused by Fonsecaea nubica and the effect of laser therapy in a Wistar rat model |
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| Snippet | 报道长脉冲1064 nm Nd∶YAG激光联合特比萘芬成功治疗Fonsecaea nubica所致着色芽生菌病1例,并探讨Enubica的真菌学、体外药敏试验和动物实验特点.患者,男,60岁,右手背约30 minx40... 报道长脉冲1064 nm Nd：YAG激光联合特比萘芬成功治疗 Fonsecaea nubica 所致着色芽生菌病1例，并探讨 F.nubica 的真菌学、体外药敏试验和动物实验特点。患者，男，60岁，右手背约30 mm×40... |
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| Title | 长脉冲1064nm Nd∶YAG激光联合特比萘芬治疗Fonsecaea nubica所致着色芽生菌病及其对大鼠模型作用 |
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