A molecularly genetic determination of prognostic factors of the prostate cancer and their relationships to expression of protein p27kip1

• Published in: Neoplasma Vol. 54; no. 2; p. 149
• Main Authors: Dvorácková, J, Uvírová, M
• Format: Journal Article
• Language: English
• Published: Slovakia 2007
• Subjects: Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 8 - genetics; Cyclin-Dependent Kinase Inhibitor p27 - metabolism; Gene Amplification; Humans; Immunoenzyme Techniques; In Situ Hybridization, Fluorescence; Male; Prognosis; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Proto-Oncogene Proteins c-myc - genetics; Proto-Oncogene Proteins c-myc - metabolism; Survival Rate

Loss of a part of chromosome 8p22, containing the gene LPL and amplifications of the field 8q24 comprising the c-myc oncogene are the most frequent chromosomal aberrations in prostate cancer. We aimed to find the frequency of these chromosomal abnormalities and assess their relationship to the progn...