An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity

• Published in: Gene Vol. 286; no. 1; pp. 121 - 126
• Main Authors: Bonafè, Massimiliano, Barbi, Cristiana, Olivieri, Fabiola, Yashin, Anatoli, Andreev, Kirill F, Vaupel, James W, De Benedictis, Giovanna, Rose, Giuseppina, Carrieri, Giuseppina, Jazwinski, S Michal, Franceschi, Claudio
• Format: Journal Article
• Language: English
• Published: Netherlands 06.03.2002
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Alleles; DNA, Mitochondrial - genetics; Evolution, Molecular; Female; Gene Frequency; Genes, ras - genetics; Genotype; Haplotypes; HRAS1 gene; Humans; Italy; Longevity - genetics; Male; Middle Aged; Minisatellite Repeats - genetics; RAS2 gene; Saccharomyces cerevisiae; Italy

The human HRAS1 belongs to an evolutionarily-conserved family of genes which enrolls among its members the yeast RAS2, a gene which regulates stress response and longevity in the Saccharomyces cerevisiae. In this paper we report that the frequency of the a3 allele of HRAS1 3'variable number tan...