Accumulation of cytoplasmic beta-catenin and nuclear glycogen synthase kinase 3beta in Epstein-Barr virus-infected cells

• Published in: Journal of virology Vol. 78; no. 21; pp. 11648 - 11655
• Main Authors: Everly, Jr, David N, Kusano, Shuichi, Raab-Traub, Nancy
• Format: Journal Article
• Language: English
• Published: United States 01.11.2004
• Subjects: beta Catenin; Cell Line; Cytoplasm - metabolism; Cytoskeletal Proteins - metabolism; Glycogen Synthase Kinase 3 - metabolism; Glycogen Synthase Kinase 3 beta; Herpesvirus 4, Human - physiology; Humans; Lymphocytes - metabolism; Phosphorylation; Trans-Activators - metabolism

Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with cancers in immunocompromised populations. EBV establishes a latent infection and immortalizes and transforms B lymphocytes. Several latent proteins have profound effects on cellular growth, including activation of NF-kap...