Engineering better vaccines for foot-and-mouth disease

• Published in: Developments in biologicals Vol. 114; p. 79
• Main Authors: Mason, P W, Chinsangaram, J, Moraes, M P, Mayr, G A, Grubman, M J
• Format: Journal Article
• Language: English
• Published: Switzerland 2003
• Subjects: Adenoviruses, Human - genetics; Animals; Capsid - immunology; Cell Line; Foot-and-Mouth Disease - immunology; Foot-and-Mouth Disease - prevention & control; Foot-and-Mouth Disease - transmission; Foot-and-Mouth Disease Virus - genetics; Foot-and-Mouth Disease Virus - immunology; Genetic Engineering - methods; Genetic Vectors; Humans; Viral Vaccines - biosynthesis; Viral Vaccines - genetics; Viremia - immunology; Viremia - prevention & control; Virus Replication

Although efficacious and safe, current vaccines for FMD suffer from drawbacks. Among these are that the immune response to the vaccine interferes with the ability to detect vaccinated animals that have subsequently become infected and could carry and shed the virus, creating an obstacle to re-instat...