Quantitation of dexfenfluramine/d-norfenfluramine concentration in primate brain using 19F NMR spectroscopy

• Published in: Magnetic resonance in medicine Vol. 39; no. 1; p. 149
• Main Authors: Christensen, J D, Babb, S M, Cohen, B M, Renshaw, P F
• Format: Journal Article
• Language: English
• Published: United States 01.01.1998
• Subjects: Animals; Appetite Depressants - analysis; Appetite Depressants - pharmacology; Brain - drug effects; Brain - metabolism; Brain Chemistry; Disease Models, Animal; Female; Fenfluramine - analysis; Fenfluramine - pharmacology; Fluorine Radioisotopes; Macaca mulatta; Magnetic Resonance Spectroscopy - methods; Male; Norfenfluramine - analysis; Norfenfluramine - pharmacology; Sensitivity and Specificity; Signal Processing, Computer-Assisted

Fluorine (19F) magnetic resonance spectroscopy (MRS) was used to quantify the combined concentration of the anorectic drug dexfenfluramine (DF) and its active metabolite d-norfenfluramine (dNF) in rhesus monkey brain. The accuracy of the MRS technique was assessed by comparison with gas chromatograp...