The neuronal-specific SGK1.1 kinase regulates {delta}-epithelial Na+ channel independently of PY motifs and couples it to phospholipase C signaling

• Published in: American Journal of Physiology: Cell Physiology Vol. 299; no. 4; p. C779
• Main Authors: Wesch, Diana, Miranda, Pablo, Afonso-Oramas, Domingo, Althaus, Mike, Castro-Hernández, Javier, Dominguez, Jaime, Morty, Rory E, Clauss, Wolfgang, González-Hernández, Tomás, Alvarez de la Rosa, Diego, Giraldez, Teresa
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.10.2010
• Subjects: Amino Acid Motifs; Amino Acid Sequence; Animals; Cell Line; Cerebral Cortex - cytology; Epithelial Sodium Channels - chemistry; Epithelial Sodium Channels - genetics; Epithelial Sodium Channels - metabolism; Human subjects; Humans; Immediate-Early Proteins - genetics; Immediate-Early Proteins - metabolism; Kinases; Macaca fascicularis; Molecular Sequence Data; Monkeys & apes; Mutagenesis, Site-Directed; Nervous system; Neurons; Neurons - cytology; Neurons - enzymology; Oocytes - cytology; Oocytes - physiology; Protein Isoforms - chemistry; Protein Isoforms - genetics; Protein Isoforms - metabolism; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Sequence Alignment; Signal Transduction - physiology; Sodium; Type C Phospholipases - genetics; Type C Phospholipases - metabolism; Xenopus laevis

The δ-subunit of the epithelial Na(+) channel (ENaC) is expressed in neurons of the human and monkey central nervous system and forms voltage-independent, amiloride-sensitive Na(+) channels when expressed in heterologous systems. It has been proposed that δ-ENaC could affect neuronal excitability an...