A non-invasive selective assessment of type I fibre mitochondrial function using 31P NMR spectroscopy : Evidence for impaired oxidative phosphorylation rate in skeletal muscle in patients with chronic heart failure

• Published in: European heart journal Vol. 19; no. 1; pp. 124 - 131
• Main Authors: VAN DER ENT, M, JENESON, J. A. L, REMME, W. J, BERGER, R, CIAMPRICOTTI, R, VISSER, F
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 1998
• Subjects: Adenosine Triphosphate - metabolism; Adult; Aged; Analysis of Variance; Biological and medical sciences; Cardiology. Vascular system; Case-Control Studies; Exercise Tolerance; Female; Forearm; Heart; Heart Failure - metabolism; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Medical sciences; Middle Aged; Mitochondria, Muscle - metabolism; Muscle Fibers, Slow-Twitch - metabolism; Muscle, Skeletal - metabolism; Phosphates - metabolism; Phosphocreatine - metabolism; Phosphorylation; Human; Heart failure; Chronic; Mitochondria; Spectrometry; Oxidative phosphorylation; Pathogenesis; Heart disease; Cardiovascular disease; Nuclear magnetic resonance; Striated muscle

Skeletal muscle abnormalities contribute considerably to the clinical expression of heart failure. Deconditioning, underperfusion and an increased number of type IIb glycolytical fibres lead to early lactate production and muscle fatigue at low exercise levels. Aerobic muscle metabolism may also be...