AB0077 SEMAPHORIN4B IS UPREGULATED IN RHEUMATOID ARTHRITIS PATIENTS AND INDUCES EXPRESSION OF INFLAMMATORY MEDIATORS BY MACROPHAGES AND FIBROBLAST-LIKE SYNOVIOCYTES

• Published in: Annals of the rheumatic diseases Vol. 82; no. Suppl 1; p. 1217
• Main Authors: Martínez-Ramos, S, Vidal, C Rafael, B Malvar Fernández, Perez-Gomez, N, Rodríguez, C Mouriño, Maceiras-Pan, F J, González, I Altabás, Pego-Reigosa, J M, García, S
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.06.2023
• Subjects: Calcein; Enzyme-linked immunosorbent assay; Fibroblasts; Gene expression; Inflammation; Leukocyte migration; Lipopolysaccharides; Macrophages; Monocyte chemoattractant protein 1; Monocytes; Osteoarthritis; Pathogenesis; Peripheral blood; Rheumatoid arthritis; Semaphorins; Synoviocytes; Synovium; Therapeutic targets; Wound healing; γ-Interferon

BackgroundSeveral studies have shown that different semaphorin family members are involved in the pathogenesis of rheumatoid arthritis (RA). On one hand, our group has demonstrated that (Sema)phorin 3B and Sema3F are reduced in RA patients and play a protective role. On the other hand, Sema4A and Se...