PeRiodontal Treatment to Eliminate Minority Inequality and Rural Disparities in Stroke (PREMIERS): A Multicenter, Randomized, Controlled Study
Stroke remains more common in the "buckle" of the stroke belt, and disproportionately impacts African Americans. The reasons for this racial disparity are poorly understood and are not entirely explained by traditional stroke risk factors. The PeRiodontal treatment to Eliminate Minority In...
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Published in | International journal of cerebrovascular disease and stroke Vol. 2; no. 2 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
2019
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Subjects | |
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Abstract | Stroke remains more common in the "buckle" of the stroke belt, and disproportionately impacts African Americans. The reasons for this racial disparity are poorly understood and are not entirely explained by traditional stroke risk factors. The PeRiodontal treatment to Eliminate Minority InEquality and Rural disparities in Stroke (PREMIERS) study will evaluate the effect of periodontal treatment on recurrent vascular events and stroke risk factors among ischemic stroke and transient ischemic attack patients.
Eligibility for the trial includes a non-disabling stroke confirmed by neuroimaging or Transient Ischemic Attack (TIA), being at least 18 years of age, having ≥ 5 natural teeth with ≥ 2 interproximal sites with ≥ 4 mm of clinical attachment loss and at least 2 sites with probing depth of ≥ 5 mm, and who are able to provide written informed consent. Within 90 days of the index event, patients are randomly assigned to intensive or initial standard cycle of supragingival mechanical scaling, polishing, and oral health instruction and followed for 1 year. The primary outcome is a composite of death, myocardial infarction and stroke or TIA. Secondary outcomes include A1C, fasting lipid profile, triglycerides, high sensitivity C-reactive protein, carotid intimal medial thickness, and blood pressure. A five year enrollment period followed by an addition one year of follow-up is planned. |
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AbstractList | Stroke remains more common in the "buckle" of the stroke belt, and disproportionately impacts African Americans. The reasons for this racial disparity are poorly understood and are not entirely explained by traditional stroke risk factors. The PeRiodontal treatment to Eliminate Minority InEquality and Rural disparities in Stroke (PREMIERS) study will evaluate the effect of periodontal treatment on recurrent vascular events and stroke risk factors among ischemic stroke and transient ischemic attack patients.
Eligibility for the trial includes a non-disabling stroke confirmed by neuroimaging or Transient Ischemic Attack (TIA), being at least 18 years of age, having ≥ 5 natural teeth with ≥ 2 interproximal sites with ≥ 4 mm of clinical attachment loss and at least 2 sites with probing depth of ≥ 5 mm, and who are able to provide written informed consent. Within 90 days of the index event, patients are randomly assigned to intensive or initial standard cycle of supragingival mechanical scaling, polishing, and oral health instruction and followed for 1 year. The primary outcome is a composite of death, myocardial infarction and stroke or TIA. Secondary outcomes include A1C, fasting lipid profile, triglycerides, high sensitivity C-reactive protein, carotid intimal medial thickness, and blood pressure. A five year enrollment period followed by an addition one year of follow-up is planned. |
Author | Hardin, James McMillian, Brittiny Merchant, Anwar Beck, James D Redd, Kolby T Sen, Souvik Offenbacher, Steven Phillips, S T Glover, Saundra Susin, Christiano Giamberardino, Lauren |
Author_xml | – sequence: 1 givenname: Kolby T surname: Redd fullname: Redd, Kolby T organization: Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA – sequence: 2 givenname: S T surname: Phillips fullname: Phillips, S T organization: Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina, Chapel Hill, North Carolina, USA – sequence: 3 givenname: Brittiny surname: McMillian fullname: McMillian, Brittiny organization: Department of Neurology, University of South Carolina, Columbia, South Carolina, USA – sequence: 4 givenname: Lauren surname: Giamberardino fullname: Giamberardino, Lauren organization: Department of Neurology, University of South Carolina, Columbia, South Carolina, USA – sequence: 5 givenname: James surname: Hardin fullname: Hardin, James organization: Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA – sequence: 6 givenname: Saundra surname: Glover fullname: Glover, Saundra organization: Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA – sequence: 7 givenname: Anwar surname: Merchant fullname: Merchant, Anwar organization: Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA – sequence: 8 givenname: Christiano surname: Susin fullname: Susin, Christiano organization: Division of Comprehensive Oral Health/Periodontology, Adams School of Dentistry, University of North Carolina, Chapel Hill, North Carolina, USA – sequence: 9 givenname: James D surname: Beck fullname: Beck, James D organization: Division of Comprehensive Oral Health/Periodontology, Adams School of Dentistry, University of North Carolina, Chapel Hill, North Carolina, USA – sequence: 10 givenname: Steven surname: Offenbacher fullname: Offenbacher, Steven organization: Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina, Chapel Hill, North Carolina, USA – sequence: 11 givenname: Souvik surname: Sen fullname: Sen, Souvik organization: Department of Neurology, University of South Carolina, Columbia, South Carolina, USA |
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Title | PeRiodontal Treatment to Eliminate Minority Inequality and Rural Disparities in Stroke (PREMIERS): A Multicenter, Randomized, Controlled Study |
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