910 HPV Related Cervical Carcinosarcoma

• Published in: International journal of gynecological cancer Vol. 33; no. Suppl 3; p. A101
• Main Authors: Vid Janša, Cvjeticanin, Branko, Kovac, Luka, Barbic, Matija, Blaganje, Mija, Staric, Kristina Drusany, Stefanovska, Marina Jakimovska, Macek, Katja Jakopic, Nataša Kenda Suster, Kunic, Tina, Smrkolj, Špela, Lasic, Mateja, Rosario Emanuele Carlo Distefano, Pirš, Boštjan, Meglic, Leon, Borut Kobal
• Format: Journal Article
• Language: English
• Published: Oxford BMJ Publishing Group LTD 01.09.2023
• Subjects: Case studies; Human papillomavirus; Pathogenesis
• ISSN: 1048-891X; 1525-1438
• DOI: 10.1136/ijgc-2023-ESGO.204

Introduction/BackgroundCervical carcinosarcoma is a rare and aggressive malignancy that accounts for less than 1% of all cervical cancers. There is also evidence to suggest that human papillomavirus (HPV) infection may play a role in the development of cervical carcinosarcoma. Although the exact mechanisms by which HPV may contribute to the development of carcinosarcomas are not fully understood, some studies have suggested that high-risk HPV types may be involved in the pathogenesis of these tumours.MethodologyA comprehensive literature research of studies on rare pathological entity was performed in the Pubmed Database for the literature published in the last ten years. Analysis of our case in a young patient was included.ResultsGiven the exceptional rarity of this histopathological entity evidence is still missing regarding its risk factors, pathogenesis, management and prognostic factors. It affects mainly postmenopausal patients and less than 10 cases have been reported on women younger than 40 years old, which complicates its management when dealing with patients in their fertile period as in our case. We report a case of a 26 year old woman who was referred to our clinic for a cervical lesion reported as a carcinosarcoma HPV related, its work-up and final treatment and a review of the relevant literature with a special emphasis on its management in young patients.ConclusionDue to the rarity of cervical carcinosarcoma and lack of abundant case study reports, uniform clinical guidelines for treatment following surgical resection remain unclear. However, this case study suggests that radical surgical treatment of this disease with negative margins in young patients with early-stage disease can be sufficient in treating cervical carcinosarcoma, despite their typical aggressive nature.DisclosuresThe authors declare no conflicts of interests.