RETRACTED ARTICLE: Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice

Honokiol, a constituent of Magnolia obovata , has various pharmacological effects, including protection against cerebral ischemia. However, few studies have been conducted to evaluate the possible neuroprotective effects of honokiol against cerebral ischemia. We recently reported that cerebral ische...

Full description

Saved in:
Bibliographic Details
Published inJournal of natural medicines Vol. 66; no. 4; pp. 591 - 599
Main Authors Harada, Shinichi, Kishimoto, Maya, Kobayashi, Mana, Nakamoto, Kazuo, Fujita-Hamabe, Wakako, Chen, Hwei-Hsien, Chan, Ming-Huan, Tokuyama, Shogo
Format Journal Article
LanguageEnglish
Published Singapore Springer Singapore 2012
Springer Nature B.V
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Honokiol, a constituent of Magnolia obovata , has various pharmacological effects, including protection against cerebral ischemia. However, few studies have been conducted to evaluate the possible neuroprotective effects of honokiol against cerebral ischemia. We recently reported that cerebral ischemic neuronal damage could be triggered by glucose intolerance that develops after the onset of ischemic stress (i.e., post-ischemic glucose intolerance). In addition, suppression of post-ischemic glucose intolerance significantly ameliorated ischemic neuronal damage. Here, we investigated the effects of honokiol on the development of post-ischemic glucose intolerance and neuronal damage. Mice were subjected to middle cerebral artery occlusion (MCAO) for 2 h. The development of post-ischemic glucose intolerance on day 1 and neuronal damage on day 3 after MCAO were significantly reduced by intraperitoneal administration of honokiol (10 mg/kg) compared with the vehicle-treated group. Honokiol did not affect serum insulin or adiponectin levels. However, honokiol significantly decreased the expression of phosphoenolpyruvate carboxykinase and increased the expression of 5′-AMP-activated protein kinase (AMPK) on day 1 after MCAO, compared with the vehicle-treated MCAO group. The results of this study suggest that honokiol could prevent post-ischemic glucose intolerance in an AMPK-dependent manner, which may be involved in the neuroprotective effects of honokiol against cerebral ischemia.
AbstractList Honokiol, a constituent of Magnolia obovata, has various pharmacological effects, including protection against cerebral ischemia. However, few studies have been conducted to evaluate the possible neuroprotective effects of honokiol against cerebral ischemia. We recently reported that cerebral ischemic neuronal damage could be triggered by glucose intolerance that develops after the onset of ischemic stress (i.e., post-ischemic glucose intolerance). In addition, suppression of post-ischemic glucose intolerance significantly ameliorated ischemic neuronal damage. Here, we investigated the effects of honokiol on the development of post-ischemic glucose intolerance and neuronal damage. Mice were subjected to middle cerebral artery occlusion (MCAO) for 2 h. The development of post-ischemic glucose intolerance on day 1 and neuronal damage on day 3 after MCAO were significantly reduced by intraperitoneal administration of honokiol (10 mg/kg) compared with the vehicle-treated group. Honokiol did not affect serum insulin or adiponectin levels. However, honokiol significantly decreased the expression of phosphoenolpyruvate carboxykinase and increased the expression of 5′-AMP-activated protein kinase (AMPK) on day 1 after MCAO, compared with the vehicle-treated MCAO group. The results of this study suggest that honokiol could prevent post-ischemic glucose intolerance in an AMPK-dependent manner, which may be involved in the neuroprotective effects of honokiol against cerebral ischemia.
Honokiol, a constituent of Magnolia obovata , has various pharmacological effects, including protection against cerebral ischemia. However, few studies have been conducted to evaluate the possible neuroprotective effects of honokiol against cerebral ischemia. We recently reported that cerebral ischemic neuronal damage could be triggered by glucose intolerance that develops after the onset of ischemic stress (i.e., post-ischemic glucose intolerance). In addition, suppression of post-ischemic glucose intolerance significantly ameliorated ischemic neuronal damage. Here, we investigated the effects of honokiol on the development of post-ischemic glucose intolerance and neuronal damage. Mice were subjected to middle cerebral artery occlusion (MCAO) for 2 h. The development of post-ischemic glucose intolerance on day 1 and neuronal damage on day 3 after MCAO were significantly reduced by intraperitoneal administration of honokiol (10 mg/kg) compared with the vehicle-treated group. Honokiol did not affect serum insulin or adiponectin levels. However, honokiol significantly decreased the expression of phosphoenolpyruvate carboxykinase and increased the expression of 5′-AMP-activated protein kinase (AMPK) on day 1 after MCAO, compared with the vehicle-treated MCAO group. The results of this study suggest that honokiol could prevent post-ischemic glucose intolerance in an AMPK-dependent manner, which may be involved in the neuroprotective effects of honokiol against cerebral ischemia.
Author Chen, Hwei-Hsien
Chan, Ming-Huan
Tokuyama, Shogo
Nakamoto, Kazuo
Fujita-Hamabe, Wakako
Harada, Shinichi
Kishimoto, Maya
Kobayashi, Mana
Author_xml – sequence: 1
  givenname: Shinichi
  surname: Harada
  fullname: Harada, Shinichi
  organization: Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
– sequence: 2
  givenname: Maya
  surname: Kishimoto
  fullname: Kishimoto, Maya
  organization: Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
– sequence: 3
  givenname: Mana
  surname: Kobayashi
  fullname: Kobayashi, Mana
  organization: Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
– sequence: 4
  givenname: Kazuo
  surname: Nakamoto
  fullname: Nakamoto, Kazuo
  organization: Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
– sequence: 5
  givenname: Wakako
  surname: Fujita-Hamabe
  fullname: Fujita-Hamabe, Wakako
  organization: Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
– sequence: 6
  givenname: Hwei-Hsien
  surname: Chen
  fullname: Chen, Hwei-Hsien
  organization: Institute of Pharmacology and Toxicology, Tzu Chi University
– sequence: 7
  givenname: Ming-Huan
  surname: Chan
  fullname: Chan, Ming-Huan
  organization: Institute of Pharmacology and Toxicology, Tzu Chi University
– sequence: 8
  givenname: Shogo
  surname: Tokuyama
  fullname: Tokuyama, Shogo
  email: stoku@pharm.kobegakuin.ac.jp
  organization: Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
BookMark eNpFkNFKwzAUhoNMcJs-gHcBr6NJTte03o3aucFAGL0vaXO6dXZJbVrd49sxwatzDufj5-ebkYl1Fgl5FPxZcK5evBCBiBgXgvFQAjvfkKmIwvGSMUzGHQLOIAjgjsy8P3IeSAAxJT-7NNstkyx9o8tdtkm26StdO-s-a9dQP7Rth96jp_0BqcFvbFx7QttTV9HW-Z7VvjzgqS7pvhlK55HWtncNdtqWSLU11OLQOasbavRJ7y9_OuJ4T24r3Xh8-Jtzkq3SLFmz7cf7JlluWavEmYExUayqGHRZAkCIqih5JYXSEANXUcSrQpoq0lJioSCMeGCKOA6LgGuzqATMydM1tu3c14C-z49u6MY6Ppeg-GIRKylHSl4p33a13WP3TwmeX_zmV7_56De_-M3P8Asq0HBb
ContentType Journal Article
Copyright The Japanese Society of Pharmacognosy and Springer 2012
The Japanese Society of Pharmacognosy and Springer 2012.
Copyright_xml – notice: The Japanese Society of Pharmacognosy and Springer 2012
– notice: The Japanese Society of Pharmacognosy and Springer 2012.
DBID K9.
DOI 10.1007/s11418-011-0623-x
DatabaseName ProQuest Health & Medical Complete (Alumni)
DatabaseTitle ProQuest Health & Medical Complete (Alumni)
DatabaseTitleList ProQuest Health & Medical Complete (Alumni)

DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 1861-0293
EndPage 599
ExternalDocumentID 10_1007_s11418_011_0623_x
Genre Correction/Retraction
GroupedDBID ---
-56
-5G
-BR
-EM
-Y2
-~C
.86
.VR
06C
06D
0R~
0VY
1N0
203
29L
29~
2J2
2JN
2JY
2KG
2KM
2LR
2VQ
2~H
30V
406
408
40D
40E
5GY
5VS
67Z
6NX
7.U
8TC
8UJ
95-
95.
95~
96X
AAAVM
AABHQ
AAFGU
AAHNG
AAIAL
AAJKR
AANXM
AANZL
AARHV
AARTL
AATNV
AATVU
AAUYE
AAWCG
AAYFA
AAYIU
AAYQN
AAYTO
ABBBX
ABDZT
ABECU
ABFGW
ABFTV
ABHLI
ABHQN
ABJNI
ABJOX
ABKAS
ABKCH
ABKTR
ABMNI
ABMQK
ABNWP
ABPLI
ABQBU
ABSXP
ABTEG
ABTHY
ABTKH
ABTMW
ABULA
ABWNU
ABXPI
ACBMV
ACBRV
ACBYP
ACGFS
ACHSB
ACHXU
ACIGE
ACIPQ
ACKNC
ACMDZ
ACMLO
ACOKC
ACOMO
ACSNA
ACTTH
ACVWB
ACWMK
ADHHG
ADHIR
ADINQ
ADKNI
ADKPE
ADMDM
ADOXG
ADRFC
ADTPH
ADURQ
ADYFF
ADZKW
AEBTG
AEFTE
AEGAL
AEGNC
AEJHL
AEJRE
AEKMD
AENEX
AEOHA
AEPYU
AESKC
AESTI
AETLH
AEVLU
AEVTX
AEXYK
AFLOW
AFNRJ
AFQWF
AFWTZ
AFZKB
AGAYW
AGDGC
AGGBP
AGJBK
AGMZJ
AGQMX
AGWIL
AGWZB
AGYKE
AHAVH
AHBYD
AHKAY
AHSBF
AHYZX
AIAKS
AIIXL
AILAN
AIMYW
AITGF
AJBLW
AJDOV
AJRNO
AJZVZ
AKMHD
AKQUC
ALMA_UNASSIGNED_HOLDINGS
ALWAN
AMKLP
AMXSW
AMYLF
AMYQR
AOCGG
ARMRJ
ASPBG
AVWKF
AXYYD
AZFZN
B-.
BA0
BDATZ
BGNMA
CAG
COF
CS3
CSCUP
DDRTE
DL5
DNIVK
DPUIP
DU5
EBD
EBLON
EBS
EIOEI
EJD
EMOBN
EN4
ESBYG
F5P
FEDTE
FERAY
FFXSO
FIGPU
FINBP
FNLPD
FRRFC
FSGXE
FWDCC
G-Y
G-Z
GGCAI
GGRSB
GJIRD
GNWQR
GQ6
GQ7
HG5
HG6
HLICF
HMJXF
HRMNR
HVGLF
HZ~
IHE
IJ-
IKXTQ
ITM
IWAJR
IXC
IXE
IZQ
I~X
I~Z
J-C
J0Z
JBSCW
JMI
JZLTJ
KDC
KOV
KPH
LAS
LLZTM
M4Y
MA-
MK0
MOJWN
N2Q
N9A
NB0
NPVJJ
NQJWS
NU0
O9-
O93
O9I
O9J
OK1
P9S
PF0
PQQKQ
PT4
QOR
QOS
R89
R9I
ROL
RPX
RSV
S16
S1Z
S27
S37
S3B
SAP
SBL
SDH
SHX
SISQX
SJYHP
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
SSXJD
STPWE
SV3
SZN
T13
TSG
TSK
TSV
TT1
TUC
TUS
U2A
U9L
UG4
UNUBA
UOJIU
UTJUX
UZXMN
VC2
VFIZW
W23
W48
WJK
WK8
YLTOR
Z45
Z7W
Z87
ZMTXR
ZOVNA
~A9
~KM
AACDK
AAHBH
AAJBT
AASML
ABAKF
ACAOD
ACDTI
ACZOJ
AEFQL
AEMSY
AFBBN
AGQEE
AGRTI
AIGIU
K9.
ID FETCH-LOGICAL-p71x-3dd897f93acc3336e7bc0f217a39307880fb2df8a22eb736804db996b40ad5f13
IEDL.DBID U2A
ISSN 1340-3443
IngestDate Thu Oct 10 19:17:02 EDT 2024
Sat Dec 16 12:03:28 EST 2023
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords Honokiol
Infarction
Glucose intolerance
Phosphoenolpyruvate carboxykinase
Middle cerebral artery occlusion
5′-AMP-activated protein kinase
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-p71x-3dd897f93acc3336e7bc0f217a39307880fb2df8a22eb736804db996b40ad5f13
PQID 2370559722
PQPubID 2043628
PageCount 9
ParticipantIDs proquest_journals_2370559722
springer_journals_10_1007_s11418_011_0623_x
PublicationCentury 2000
PublicationDate 10-2012
20120101
PublicationDateYYYYMMDD 2012-01-01
PublicationDate_xml – year: 2012
  text: 10-2012
PublicationDecade 2010
PublicationPlace Singapore
PublicationPlace_xml – name: Singapore
– name: Heidelberg
PublicationTitle Journal of natural medicines
PublicationTitleAbbrev J Nat Med
PublicationYear 2012
Publisher Springer Singapore
Springer Nature B.V
Publisher_xml – name: Springer Singapore
– name: Springer Nature B.V
References YamauchiTKamonJMinokoshiYItoYWakiHUchidaSYamashitaSNodaMKitaSUekiKEtoKAkanumaYFroguelPFoufelleFFerrePCarlingDKimuraSNagaiRKahnBBKadowakiTAdiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinaseNat Med20028128812951:CAS:528:DC%2BD38XotlWlsrg%3D10.1038/nm788
ChenCMLiuSHLin-ShiauSYHonokiol, a neuroprotectant against mouse cerebral ischaemia, mediated by preserving Na+, K+-ATPase activity and mitochondrial functionsBasic Clin Pharmacol Toxicol20071011081161:CAS:528:DC%2BD2sXptlyltLs%3D10.1111/j.1742-7843.2007.00082.x
MihaylovaMMVasquezDSRavnskjaerKDenechaudPDYuRTAlvarezJGDownesMEvansRMMontminyMShawRJClass IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasisCell20111456076211:CAS:528:DC%2BC3MXmtFGmtb4%3D10.1016/j.cell.2011.03.043
LinYRChenHHKoCHChanMHDifferential inhibitory effects of honokiol and magnolol on excitatory amino acid-evoked cation signals and NMDA-induced seizuresNeuropharmacology2005495425501:CAS:528:DC%2BD2MXosVCrtL4%3D10.1016/j.neuropharm.2005.04.009
BergerLHakimAMThe association of hyperglycemia with cerebral edema in strokeStroke1986178658711:STN:280:DyaL2s%2FitVSjuw%3D%3D10.1161/01.STR.17.5.865
TairaJIkemotoTMimuraKHagiAMurakamiAMakinoKEffective inhibition of hydroxyl radicals by hydroxylated biphenyl compoundsFree Radic Res Commun199319Suppl 1S71S771:CAS:528:DyaK2cXhtFKntbY%3D10.3109/10715769309056s71
SuzukiNClinical application of dietary supplementsNippon Yakurigaku Zasshi20081312522571:CAS:528:DC%2BD1cXkvFSitbY%3D10.1254/fpj.131.252
LiouKTShenYCChenCFTsaoCMTsaiSKHonokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species productionBrain Res20039921591661:CAS:528:DC%2BD3sXptVSiurc%3D10.1016/j.brainres.2003.08.026
KitagawaKMatsumotoMOdaTNiinobeMHataRHandaNFukunagaRIsakaYKimuraKMaedaHFree radical generation during brief period of cerebral ischemia may trigger delayed neuronal deathNeuroscience1990355515581:CAS:528:DyaK3cXltlSjurw%3D10.1016/0306-4522(90)90328-2
WidmerHAbikoHFadenAIJamesTLWeinsteinPREffects of hyperglycemia on the time course of changes in energy metabolism and pH during global cerebral ischemia and reperfusion in rats: correlation of 1H and 31P NMR spectroscopy with fatty acid and excitatory amino acid levelsJ Cereb Blood Flow Metab1992124564681:CAS:528:DyaK38Xkt1CitLY%3D10.1038/jcbfm.1992.63
IrieTMiyamotoEKitagawaKMaruyamaYInoueKInagakiCAn anxiolytic agent, dihydrohonokiol-B, inhibits ammonia-induced increases in the intracellular Cl(−) of cultured rat hippocampal neurons via GABA(c) receptorsNeurosci Lett20013121211231:CAS:528:DC%2BD3MXntlOqtbs%3D10.1016/S0304-3940(01)02201-7
ChoiSSChaBYIidaKSatoMLeeYSTeruyaTYonezawaTNagaiKWooJTHonokiol enhances adipocyte differentiation by potentiating insulin signaling in 3T3-L1 preadipocytesJ Nat Med2011654244301:CAS:528:DC%2BC3MXns12msb0%3D10.1007/s11418-011-0512-3
ShichiKFujita-HamabeWHaradaSMizoguchiHYamadaKNabeshimaTTokuyamaSInvolvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damageJ Pharmacol Exp Ther20113387017101:CAS:528:DC%2BC3MXpvFels7w%3D10.1124/jpet.110.178079
TengCMChenCCKoFNLeeLGHuangTFChenYPHsuHYTwo antiplatelet agents from Magnolia officinalisThromb Res1988507577651:CAS:528:DyaL1cXkvVKjs70%3D10.1016/0049-3848(88)90336-2
RonnettGVRamamurthySKlemanAMLandreeLEAjaSAMPK in the brain: its roles in energy balance and neuroprotectionJ Neurochem2009109Suppl 117231:CAS:528:DC%2BD1MXlsFyks7c%3D10.1111/j.1471-4159.2009.05916.x
MerrillGFKurthEJHardieDGWinderWWAICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscleAm J Physiol1997273E1107E11121:CAS:528:DyaK1cXjvFSmtw%3D%3D9435525
ChiuJHHoCTWeiYHLuiWYHongCYIn vitro and in vivo protective effect of honokiol on rat liver from peroxidative injuryLife Sci199761196119711:CAS:528:DyaK2sXmslentrY%3D10.1016/S0024-3205(97)00836-9
FukuyamaYNakadeKMinoshimaYYokoyamaRZhaiHMitsumotoYNeurotrophic activity of honokiol on the cultures of fetal rat cortical neuronsBioorg Med Chem Lett200212116311661:CAS:528:DC%2BD38XisFWgtr4%3D10.1016/S0960-894X(02)00112-9
World Health Organization (2000) Guidelines for the regulatory assessment of medicinal products for use in self-medication. WHO, Geneva
LiuBHattoriNZhangNYWuBYangLKitagawaKXiongZMIrieTInagakiCAnxiolytic agent, dihydrohonokiol-B, recovers amyloid beta protein-induced neurotoxicity in cultured rat hippocampal neuronsNeurosci Lett200538444471:CAS:528:DC%2BD2MXlt1Kiurw%3D10.1016/j.neulet.2005.04.081
KaganskyNLevySKnoblerHThe role of hyperglycemia in acute strokeArch Neurol200158120912121:STN:280:DC%2BD3MvosVOisw%3D%3D10.1001/archneur.58.8.1209
HallEDBraughlerJMCentral nervous system trauma and stroke. II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidationFree Radic Biol Med198963033131:STN:280:DyaL1Mzgs1ymtQ%3D%3D10.1016/0891-5849(89)90057-9
FujitaMItokawaHSashidaYStudies on the components of Magnolia obovata Thunb. 3. Occurrence of magnolol and honokiol in M. obovata and other allied plantsYakugaku Zasshi1973934294341:CAS:528:DyaE3sXksFaqsLg%3D10.1248/yakushi1947.93.4_429
KahnBBAlquierTCarlingDHardieDGAMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolismCell Metab2005115251:CAS:528:DC%2BD2MXhtlaqs74%3D10.1016/j.cmet.2004.12.003
ToniDDe MicheleMFiorelliMBastianelloSCamerlingoMSacchettiMLArgentinoCFieschiCInfluence of hyperglycaemia on infarct size and clinical outcome of acute ischemic stroke patients with intracranial arterial occlusionJ Neurol Sci19941231291331:STN:280:DyaK2czkt12hsQ%3D%3D10.1016/0022-510X(94)90214-3
FolbergrovaJMemezawaHSmithMLSiesjoBKFocal and perifocal changes in tissue energy state during middle cerebral artery occlusion in normo- and hyperglycemic ratsJ Cereb Blood Flow Metab19921225331:CAS:528:DyaK38XhsV2gurs%3D10.1038/jcbfm.1992.4
SonHJLeeHJYun-ChoiHSRyuJHInhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophagesPlanta Med2000664694711:CAS:528:DC%2BD3cXksVOmtLY%3D10.1055/s-2000-8592
FlammESDemopoulosHBSeligmanMLPoserRGRansohoffJFree radicals in cerebral ischemiaStroke197894454471:CAS:528:DyaE1cXlslOnu7Y%3D10.1161/01.STR.9.5.445
LoYCTengCMChenCFChenCCHongCYMagnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidationBiochem Pharmacol1994475495531:CAS:528:DyaK2cXitVymtL4%3D10.1016/0006-2952(94)90187-2
HayashiTHirshmanMFKurthEJWinderWWGoodyearLJEvidence for 5′ AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transportDiabetes199847136913731:CAS:528:DyaK1cXltFyrtb4%3D9703344
HaradaSHamabeWKamiyaKSatakeTYamamotoJTokuyamaSPreventive effect of Morinda citrifolia fruit juice on neuronal damage induced by focal ischemiaBiol Pharm Bull2009324054091:CAS:528:DC%2BD1MXmsVansLg%3D10.1248/bpb.32.405
HaradaSFujita-HamabeWTokuyamaSThe importance of regulation of blood glucose levels through activation of peripheral 5′-AMP-activated protein kinase on ischemic neuronal damageBrain Res201013512542631:CAS:528:DC%2BC3cXhtVKjtbvJ10.1016/j.brainres.2010.06.052
Alonso-CastroAJZapata-BustosRDominguezFGarcia-CarrancaASalazar-OlivoLAMagnolia dealbata Zucc and its active principles honokiol and magnolol stimulate glucose uptake in murine and human adipocytes using the insulin-signaling pathwayPhytomedicine2011189269331:CAS:528:DC%2BC3MXhtVKjs7bP10.1016/j.phymed.2011.02.015
HaradaSFujitaWHShichiKTokuyamaSThe development of glucose intolerance after focal cerebral ischemia participates in subsequent neuronal damageBrain Res200912791741811:CAS:528:DC%2BD1MXnsFajtro%3D10.1016/j.brainres.2009.05.014
ZhaiHNakadeKOdaMMitsumotoYAkagiMSakuraiJFukuyamaYHonokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2)Eur J Pharmacol20055161121171:CAS:528:DC%2BD2MXltFSqsLs%3D10.1016/j.ejphar.2005.04.035
EnnisSRKeepRFEffect of sustained-mild and transient-severe hyperglycemia on ischemia-induced blood–brain barrier openingJ Cereb Blood Flow Metab200727157315821:CAS:528:DC%2BD2sXptlSqtr4%3D10.1038/sj.jcbfm.9600454
DietrichWDAlonsoOBustoRModerate hyperglycemia worsens acute blood–brain barrier injury after forebrain ischemia in ratsStroke1993241111161:STN:280:DyaK3s7hvVSkug%3D%3D10.1161/01.STR.24.1.111
HaradaSFujita-HamabeWTokuyamaSEffect of orexin-A on post-ischemic glucose intolerance and neuronal damageJ Pharmacol Sci20111151551631:CAS:528:DC%2BC3MXivVKrtLo%3D10.1254/jphs.10264FP
References_xml
SSID ssj0042331
Score 1.9157027
Snippet Honokiol, a constituent of Magnolia obovata , has various pharmacological effects, including protection against cerebral ischemia. However, few studies have...
Honokiol, a constituent of Magnolia obovata, has various pharmacological effects, including protection against cerebral ischemia. However, few studies have...
SourceID proquest
springer
SourceType Aggregation Database
Publisher
StartPage 591
SubjectTerms Biomedicine
Complementary & Alternative Medicine
Medicinal Chemistry
Original Paper
Pharmacology/Toxicology
Pharmacy
Plant Sciences
Title RETRACTED ARTICLE: Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice
URI https://link.springer.com/article/10.1007/s11418-011-0623-x
https://www.proquest.com/docview/2370559722
Volume 66
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LS8NAEF7EXryIT3yWOYgXXUl2Ny9vpbTWJ1Ja0FPYzW6gVJNiWmz_vbNpY1C8eN4Qlp3Ml292vpkh5MyTSApMGFFXB4wiSkoqeZhQzwsjXyNDN8zWDj8--b2huHvxXtYI-766yMZXVUayBOq61s0VrtVdWaEO4xR5YwO5g7AyriFrVeiL7IAvgyyB-CIErzKZf73iB6v8lQgt_y_dLbK5IobQWlpym6yZbIecPy87Sy8uYVAXShWXcA7Pdc_pxS757HcG_VYbYQiQod62HzrX0MuzfDzK36CYTUq5qykA6R7oWicEeQqTvJjSEQa5ViYPKwk7jLJp_mbs1A0DMtNQ9r20G9TyHSEI18EOst8jg25n0O7R1UwFOgncOeVah1GQRlwmCefcN4FKnBTDEskj9HZ05lQxnYaSMaMC7oeO0ApDIiUcqb3U5ftkPcszc0BA-MpEItBSCSn8UEVp6CfCNndxnNQPxCE5qQ43XvlFETNuu_dEAWOH5KI68Hq57qFsLRWjpWJrqXh-9K-nj8kG8hq2vCk5IevTj5k5Re4wVU3SaN283nea5UfzBcyjvug
link.rule.ids 315,783,787,27938,27939,41095,41537,42164,42606,52125,52248
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LS-wwFA4yLnRzfVwv1_dZiJtrpE3Sl7thGB11FJEKuipJk8KgtoPt4OPXezJtKcrduE4oB0769Ts93_lCyIEnkRSYMKKuDhhFlJRU8jClnhdGvkaGbpidHb669kd34uLeu2_muMtW7d62JOdI3Q27ucK1wiur1GGcInFcFAzZfo8s9s8eLoctACNB4HWdJRBihOBtM_N_D_lCLL_1QuefmNMVErfB1cqSx-NZpY7Tj2--jT-MfpX8aign9OszskYWTL5ODm9qz-r3I4i7EazyCA7hpnOzfv9NXm-H8W1_gAAHyH3PB-PhCYyKvHicFE9QzqZzIa0pAYkk6E6BBEUG06Ks6ATLZyvAh0YcD5O8Kp6Mvc_DgMw1zB01bYBaPiO44TrgdrNB4tNhPBjR5rYGOg3cN8q1DqMgi7hMU865bwKVOhkWPJJHiCMIE5liOgslY0YF3A8doRUWW0o4UnuZy_-QXl7k5i8B4SsTiUBLJaTwQxVloZ8KaxvjOJkfiE2y0-Ysad64MmHc-gJFAWOb5F-bgm65c2e2eUgwD4nNQ_K29aPd-2RpFF-Nk_H59eU2WUb2xOr_MTukV73MzC4ylErtNSfyE8xL3ao
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3fT9swELYmJk17QcCYYINxD4gXapHYzi_eqtKqMIaqqpX6FtmxLVWwpFqCaP97zk2iaIgXnh1Fli93_i733XeEnAcSQYGJE-rriFGMkpJKHmc0COIk1IjQDXO9w38ewvFc3C2CRTPntGzZ7m1Jsu5pcCpNeXW10vaqa3zzhe9IWI61wzhFEPkZbyLusq8567ehGKECrzMugcFGCN6WNd97xX8Q801VdHvZjPbIboMSoV-bdZ98MvkBuZjUMtObHsy6rqmyBxcw6QSoN9_Iy3Q4m_YHGJMA4ert4H54DeMiLx6XxROUz6st99WUgNgPdEcagsLCqigrusSM13HmoeGzwzKviifjRnAYkLmGrQim26CWfzEe4Tq4qfaHZDYazgZj2gxYoKvIX1OudZxENuEyyzjnoYlU5lnMUSRP0PXRs61i2saSMaMiHsae0ArzIyU8qQPr8-9kJy9yc0RAhMokItJSCSnCWCU2DjPhlF48z4aROCYn7eGmjZOUKeNOyieJGDsml-2Bd8udoLKzVIqWSp2l0vWPDz19Rr5Mbkbp_e3D75_kK-IdVv9BOSE71b9nc4qYolK_tt_NK1ymxPQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=RETRACTED+ARTICLE%3A+Honokiol+suppresses+the+development+of+post-ischemic+glucose+intolerance+and+neuronal+damage+in+mice&rft.jtitle=Journal+of+natural+medicines&rft.au=Harada+Shinichi&rft.au=Kishimoto%2C+Maya&rft.au=Kobayashi+Mana&rft.au=Nakamoto+Kazuo&rft.date=2012-01-01&rft.pub=Springer+Nature+B.V&rft.issn=1340-3443&rft.eissn=1861-0293&rft.volume=66&rft.issue=4&rft.spage=591&rft.epage=599&rft_id=info:doi/10.1007%2Fs11418-011-0623-x&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1340-3443&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1340-3443&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1340-3443&client=summon