In-silico analysis: common biomarkers of NDs

• Published in: bioRxiv
• Main Authors: Sarkar, Deepanjan, Chakraborty, Souvik, Maiti, Tarasankar, Bhowmick, Sushmita
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 27.09.2021
• Subjects: Alzheimer's disease; Biomarkers; Drug development; Huntington's disease; Janus kinase 2; Movement disorders; Multiple sclerosis; Neurodegenerative diseases; Neurological diseases; Parkinson's disease; Protein interaction
• DOI: 10.1101/2021.09.25.461779

Neurodegenerative disorders (NDs) are a class of rapidly rising devastating diseases and the reason behind are might be an improper function of related genes or a mutation in a particular gene or even could be autoimmune also. Parkinsons disease (PD), Multiple sclerosis (MS), Huntingtons disease (HD) are some of the NDs, and still, incurable fully. Apart from the similarities in symptoms, there are common genes that express somehow a differential manner in patients of PDs, MSs, and HDs. A total of 1197 differentially expressed genes (DEGs) are obtained by analyzing the chosen datasets. The protein interactions by STRING online tool and degree sorted hubs obtained through a plug-in in Cytoscape; Cyto-Hubba. Among the sorted hubs KRAS, CREB1, PIK3CA, JAK2 are the ones that are not only common to all the studied datasets of NDs but also in other neurological disorders like Alzheimers. The enriched pathways with biological process, molecular function, cellular component, and KEGG pathway details are obtained and analyzed using Enricher. This paper frames that the obtained hub genes could be potential biomarkers also and a need for further drug design for finding a possible cure. Competing Interest Statement The authors have declared no competing interest. Footnotes * https://docs.google.com/spreadsheets/d/1V-MmELfiv_AcD6HA5y6dVjguM5O1iL_9h_vxlaRMx7s/edit#gid=0 * https://docs.google.com/spreadsheets/d/1NyphpqerUx6DQKaV1vDOd-c7U0lATrdc14SQsVT7_zA/edit#gid=0 * https://docs.google.com/spreadsheets/d/1pr-wte5YxTNcC4-4QQ7K1al1DHoui2jRRQJ6yCuZNX4/edit#gid=0 * https://drive.google.com/drive/folders/12jRQ_l7zCeJok9KNnaqKKCqYVYuR_pzw?usp=sharing