Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection

• Published in: bioRxiv
• Main Authors: Nina Le Bert, Clapham, Hannah E, Tan, Anthony T, Wan Ni Chia, Christine Yl Tham, Lim, Jane M, Kunasegaran, Kamini, Tan, Linda, Charles-Antoine Dutertre, Shankar, Nivedita, Lim, Joey Me, Louisa Jin Sun, Zahari, Marina, Tun, Zaw Myo, Kumar, Vishakha, Beng Lee Lim, Lim, Siew Hoon, Chia, Adeline, Yee-Joo, Tan, Tambyah, Paul Anantharajah, Kalimuddin, Shirin, Lye, David, Low, Jenny Gh, Lin-Fa, Wang, Wan, Wei Yee, Li Yang Hsu, Bertoletti, Antonio, Tam, Clarence C
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 27.11.2020
• Subjects: Asymptomatic; Asymptomatic infection; Cell activation; COVID-19; Cytokines; Enzyme-linked immunosorbent assay; IL-1β; Immune clearance; Immune response (cell-mediated); Infections; Inflammation; Interleukin 10; Interleukin 2; Interleukin 4; Interleukin 6; Lymphocytes; Lymphocytes T; Seroconversion; Severe acute respiratory syndrome coronavirus 2; Structural proteins; Tumor necrosis factor-α; Viruses; γ-Interferon

Abstract The efficacy of virus-specific T cells in clearing pathogens involves a fine balance between their antiviral and inflammatory features. SARS-CoV-2-specific T cells in individuals who clear SARS-CoV-2 infection without symptoms or disease could reveal non-pathological yet protective characte...